Zobrazeno 1 - 10
of 28
pro vyhledávání: '"D. Tew"'
Autor:
Leilei Zhang, Claudia M. Ludden, Alexander J. Cullen, Kenneth D. Tew, André Luís Branco de Barros, Danyelle M. Townsend
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115459- (2023)
In this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in the expression of genes involved in inflammation, proliferation, and apoptosis pathways, and link it with prognosis of various human cancers, particularly
Externí odkaz:
https://doaj.org/article/6a59c99872434363a3b346b863248ec3
Autor:
Jie Zhang, Zhi-wei Ye, Paramita Chakraborty, Zhenwu Luo, John Culpepper, Muhammad Aslam, Leilei Zhang, Katarina Johansson, Jesper Z. Haeggström, Jianqiang Xu, Magnus Olsson, Danyelle M. Townsend, Shikhar Mehrotra, Ralf Morgenstern, Kenneth D. Tew
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106899- (2023)
While recent targeted and immunotherapies in malignant melanoma are encouraging, most patients acquire resistance, implicating a need to identify additional drug targets to improve outcomes. Recently, attention has been given to pathways that regulat
Externí odkaz:
https://doaj.org/article/5d9d42b0e955458aadc407c65b31b648
Autor:
Kenneth D. Tew, Leilei Zhang
Publikováno v:
Advances in Cancer Research ISBN: 9780128241257
Reductive stress is defined as a condition characterized by excess accumulation of reducing equivalents (e.g., NADH, NADPH, GSH), surpassing the activity of endogenous oxidoreductases. Excessive reducing equivalents can perturb cell signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96389d053e5f3673a4e472a817b411b1
https://doi.org/10.1016/bs.acr.2021.03.009
https://doi.org/10.1016/bs.acr.2021.03.009
Publikováno v:
Advances in Cancer Research ISBN: 9780128241257
Adv Cancer Res
Adv Cancer Res
Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This review details those biochemical pathways and metabolic conversio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a885957eb80cf56f73081b80deadf97
https://doi.org/10.1016/bs.acr.2021.03.008
https://doi.org/10.1016/bs.acr.2021.03.008
Publikováno v:
Chemical Engineering Science: X, Vol 4, Iss, Pp-(2019)
Initial wetting of crystals by binder droplets is a key rate process in spherical agglomeration, however there are no models to predict the kinetics and formation of agglomerate nuclei. Two new mathematical models are introduced for agglomerate nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf376cc3deb9856ee262ff74889aa519
https://eprints.whiterose.ac.uk/152688/1/1-s2.0-S2590140019300553-main.pdf
https://eprints.whiterose.ac.uk/152688/1/1-s2.0-S2590140019300553-main.pdf
Autor:
Danyelle M. Townsend, Kenneth D. Tew, Kristian Dreij, Katarina Johansson, Hiroshi Abe, Michael J. Kelner, Ralf Morgenstern, Arne Holmgren, Linda Spahiu, Jie Zhang, Lars Bräutigam
Publikováno v:
Redox Biology, Vol 17, Iss, Pp 171-179 (2018)
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an
Autor:
Danyelle M. Townsend, Yvonne M. W. Janssen-Heininger, Albert van der Vliet, Jos van der Velden, Jane T. Jones, Xi Qian, Kenneth D. Tew, Shi Biao Chia, James D. Nolin, Sidra M. Hoffman, Robert W. Schneider, Stevenson Flemer, Vikas Anathy, Karolyn G. Lahue, David H. McMillan
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 375-382 (2016)
Redox Biology
Redox Biology
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or the conju
Autor:
Yefim Manevich, Danyelle M. Townsend, Christina L. Grek, Zhi-Wei Ye, Kenneth D. Tew, Jie Zhang
Glutathione S-transferase P (GSTP) is one member of the GST superfamily that is prevalently expressed in mammals. Known to possess catalytic activity through deprotonating glutathione allowing formation of thioether bonds with electrophilic substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6997a00803cf64c8734b581dd5b1f77
https://doi.org/10.1016/b978-0-12-420117-0.00004-9
https://doi.org/10.1016/b978-0-12-420117-0.00004-9