Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M. Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B. Muir, Kelly A. Whelan, Shinya Ohashi, Seiji Naganuma, Andres J. Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J. Bass, J. Alan Diehl, Gregory G. Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G. Avadhani, Devraj Basu, Anil K. Rustgi, Shoji Natsugoe
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thr
Externí odkaz:
https://doaj.org/article/7488edc6ab024bcda04958703e1f2938
Autor:
Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muir, Hiroshi Nakagawa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to stud
Externí odkaz:
https://doaj.org/article/21163af81d7441fbb6e128ef99587eeb
Autor:
Linara Gabitova, Diana Restifo, Andrey Gorin, Kunal Manocha, Elizabeth Handorf, Dong-Hua Yang, Kathy Q. Cai, Andres J. Klein-Szanto, David Cunningham, Lisa E. Kratz, Gail E. Herman, Erica A. Golemis, Igor Astsaturov
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1927-1938 (2015)
Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand for ch
Externí odkaz:
https://doaj.org/article/636b13b697ca49f097e54c092b8a97eb
Autor:
Toya M. Albury, Veethika Pandey, Sarah B. Gitto, Lisette Dominguez, Lina P. Spinel, Jacqueline Talarchek, Andres J. Klein-Szanto, Joseph R. Testa, Deborah A. Altomare
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 2, Pp 175-182 (2015)
BACKGROUND AND AIMS: Pancreatic adenocarcinoma is a deadly disease characterized by metastatic progression and resistance to conventional therapeutics. Mutation of KRAS is the most frequent early event in pancreatic tumor progression. AKT isoforms ar
Externí odkaz:
https://doaj.org/article/2e0685aa68c54857b9361760dd9def1a
Autor:
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 2, Pp 169-179 (2013)
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relev
Externí odkaz:
https://doaj.org/article/8e865a2e44094a669fb463be3cd7dc0a
Autor:
Daniel E. Bassi, Tianyu Li, Emmanuelle Nicolas, Jirong Zhang, Andres J. Klein-Szanto, Jian Fu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 271-282 (2012)
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clini
Publikováno v:
Handbook of Toxicologic Pathology (Second Edition)
This chapter reviews the structure and differentiation patterns of normal skin.. Skin is one of the largest organs of mammals; thus, it is often exposed to physical or chemical agents. This chapter provides an overview of the fundamental histopatholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c5e985b384fb0bab33c0e9c8c37eee
https://doi.org/10.1016/b978-012330215-1/50030-2
https://doi.org/10.1016/b978-012330215-1/50030-2
Publisher Summary The epidermis is composed of several cell subpopulations that include different types of epithelial and nonepithelial cells. Several morphological, histochemical, and immunohistochemical techniques developed in the past few decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7d52ddec49c0a4ce16933890c50c88
https://doi.org/10.1016/b978-0-12-564505-8.50014-9
https://doi.org/10.1016/b978-0-12-564505-8.50014-9