Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tamura A"'
Autor:
Takahiro Yamamoto, Takuji Machida, Chiho Tanno, Shiori Hasebe, Mayu Tamura, Nanaka Kobayashi, Sachiko Hiraide, Naoya Hamaue, Kenji Iizuka
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 2, Pp 90-102 (2023)
We aimed to clarify the effect of nafamostat mesilate (nafamostat) on intestinal mucositis as well as the potentiation of intestinal 5-hydroxytryptamine (5-HT) dynamics induced by methotrexate, an anti-cancer drug, in rats. Rats received intraperiton
Externí odkaz:
https://doaj.org/article/4e1bfa9e836d46dbb172d84c6045b8c1
Autor:
Masayuki Nakano, Motoaki Saito, Tatsuo Hashimoto, Motokazu Koga, Kouichi Tamura, Yoshio Goshima, Yusuke Mizuno, Fumio Nakamura, Hiraku Uchimura, Daiki Masukawa, Suo Zou, Takahiro Shimizu, Ryo Niikura, Tomoyuki Miyazaki, Takahisa Goto, Natsuki Matsushita
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 2, Pp 214-220 (2022)
Pulmonary hypertension (PH) is a severe and progressive disease that causes elevated right ventricular systolic pressure, right ventricular hypertrophy and ultimately right heart failure. However, the underlying pathophysiologic mechanisms are poorly
Autor:
Tatsuma Ban, Daisuke Kurotaki, Kappei Tsukahara, Hiroshi Ishihara, Tadatsugu Taniguchi, Hideyuki Yanai, Wataru Kawase, Tomohiko Tamura, Go R. Sato, Yuta Suzuki, Juri Ichikawa
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 708-715 (2021)
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 708-715 (2021)
RNA interference-based gene silencing drugs are attracting attention for treating various diseases. Lipid nanoparticles (LNPs) are carriers that efficiently deliver small interfering RNA (siRNA) to the cytoplasm of target cells. Recently, we develope
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 259-266 (2022)
Uterine leiomyosarcoma is an aggressive soft tissue tumor. Stathmin, a phosphoprotein that modulates microtubule dynamics, is highly expressed in many malignancies including leiomyosarcoma. The microtubule-depolymerizing agent eribulin has been recen
Externí odkaz:
https://doaj.org/article/22ec3201c253415f9d8adb80b39c5e4e
Autor:
Sangjon Pae, Shinichi Sakamoto, Xue Zhao, Shinpei Saito, Takaaki Tamura, Yusuke Imamura, Tomokazu Sazuka, Yoshie Reien, Yuri Hirayama, Hirofumi Hashimoto, Yoshikatsu Kanai, Tomohiko Ichikawa, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 251-258 (2022)
Amino acid transporters are responsible for the uptake of amino acids, critical for cell proliferation. L-type amino acid transporters play a major role in the uptake of essential amino acids. L-type amino acid transporter 1 (LAT1) exerts its functio
Externí odkaz:
https://doaj.org/article/022a458a306f4c69a54fb82a03f4a895
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 4, Pp 267-274 (2022)
The pathogenesis of hypertensive disorder of pregnancy (HDP), which affects about 10% of pregnant women, is still incompletely understood. Our previous study showed that endoplasmic reticulum (ER) stress influences high-temperature requirement A seri
Externí odkaz:
https://doaj.org/article/661b0f57eb7d4142a7e3254510f02246
Autor:
Yuki Kawai, Yoshiyuki Toya, Hiromichi Wakui, Tetsuya Fujikawa, Eiko Ueda, Kengo Azushima, Sho Kinguchi, Hiroshi Mitsuhashi, Tomoyuki Kawano, Tadashi Kuji, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 118-125 (2021)
Our previous randomized controlled trial comparing the total dose of weekly versus biweekly continuous erythropoietin receptor activator (CERA) therapy to maintain optimal hemoglobin (Hb) levels showed no significant differences between the two thera
Externí odkaz:
https://doaj.org/article/bc8b5ab08cbb441db2084058f0dfc4de
Autor:
Wataru Kawase, Daisuke Kurotaki, Yuta Suzuki, Hiroshi Ishihara, Tatsuma Ban, Go R. Sato, Juri Ichikawa, Hideyuki Yanai, Tadatsugu Taniguchi, Kappei Tsukahara, Tomohiko Tamura
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 708-715 (2021)
RNA interference-based gene silencing drugs are attracting attention for treating various diseases. Lipid nanoparticles (LNPs) are carriers that efficiently deliver small interfering RNA (siRNA) to the cytoplasm of target cells. Recently, we develope
Externí odkaz:
https://doaj.org/article/fa32f02bafe74885ab7b0205c2666905
Autor:
Susumu Ishiguro, Deepa Upreti, Nicole Robben, Riley Burghart, Mayme Loyd, Damilola Ogun, Tran Le, Jennifer Delzeit, Arashi Nakashima, Ravindra Thakkar, Ayaka Nakashima, Kengo Suzuki, Jeffrey Comer, Masaaki Tamura
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 127, Iss , Pp 110166- (2020)
The partially purified water extract from Euglena gracilis (EWE) was evaluated for its antitumor and immunomodulatory effects in cell cultures and in a mouse orthotopic lung carcinoma allograft model. In two-dimensional cell culture, the EWE treatmen
Externí odkaz:
https://doaj.org/article/daca489ba7fc4e85b7b0ee359fe87143
Autor:
Kazuhiro Tamura, Gen Ishikawa, Mikihiro Yoshie, Wakana Ohneda, Akihito Nakai, Toshiyuki Takeshita, Eiichi Tachikawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 89-95 (2017)
Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway
Externí odkaz:
https://doaj.org/article/a87c5b7c6c5e43159dadeca50bc8f9cb