Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jensen, A"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110118- (2024)
Summary: Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universal
Externí odkaz:
https://doaj.org/article/4557e5fca03e40ca901e681a67dd9748
Autor:
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109693- (2024)
Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describ
Externí odkaz:
https://doaj.org/article/ad0bc59a163a477bae0474b6a3ff6a2d
Autor:
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108839- (2024)
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next generation of drugs requires enhanced sele
Externí odkaz:
https://doaj.org/article/ff5d053643f145278c5b251d0afc7838
Autor:
Arsenios Vlassis, Tanja L. Jensen, Marina Mohr, Dominika J. Jedrzejczyk, Xiangyou Meng, Gergo Kovacs, Martí Morera-Gómez, Andrea Barghetti, Sergi Muyo Abad, Roland F. Baumgartner, Kedar N. Natarajan, Lars K. Nielsen, Tanya Warnecke, Ryan T. Gill
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108287- (2023)
Summary: Discovery of genomic safe harbor sites (SHSs) is fundamental for multiple transgene integrations, such as reporter genes, chimeric antigen receptors (CARs), and safety switches, which are required for safe cell products for regenerative cell
Externí odkaz:
https://doaj.org/article/1ed7e3c6b32b4486a833882c76203d11
Autor:
Maja Jensen, Venkataragavan Chandrasekaran, María-José García-Bonete, Shuxiang Li, Atsarina Larasati Anindya, Karin Andersson, Malin C. Erlandsson, Nina Y. Oparina, Björn M. Burmann, Ulrika Brath, Anna R. Panchenko, Maria Bokarewa I., Gergely Katona
Publikováno v:
iScience, Vol 26, Iss 7, Pp 106976- (2023)
Summary: This study investigates the role of survivin in epigenetic control of gene transcription through interaction with the polycomb repressive complex 2 (PRC2). PRC2 is responsible for silencing gene expression by trimethylating lysine 27 on hist
Externí odkaz:
https://doaj.org/article/2a016a9234b84d828c02e744b446d7da
Autor:
Yvonne Adams, Anne Skovsbo Clausen, Peter Østrup Jensen, Malin Lager, Peter Wilhelmsson, Anna J. Henningson, Per-Eric Lindgren, Daniel Faurholt-Jepsen, Helene Mens, Peter Kraiczy, Kasper Nørskov Kragh, Thomas Bjarnsholt, Andreas Kjaer, Anne-Mette Lebech, Anja R. Jensen
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105838- (2023)
Summary: Lyme neuroborreliosis (LNB), a tick-borne infection caused by spirochetes within the Borrelia burgdorferi sensu lato (s.L.) complex, is among the most prevalent bacterial central nervous system (CNS) infections in Europe and the US. Here we
Externí odkaz:
https://doaj.org/article/c337888d88e645838d653b41c3cef6d6
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102008- (2023)
Summary: The ability of stem cells to activate and differentiate is critical for maintaining the regenerative capacity of skeletal muscle. Here, we detail steps for specific quantification and isolation of primary human fibro-adipogenic progenitors a
Externí odkaz:
https://doaj.org/article/9c3cb13ccddc4cf2ab31f1caaf658ca3
Autor:
Randi Bonke Mikkelsen, Tulika Arora, Kajetan Trošt, Oksana Dmytriyeva, Sune Kjærsgaard Jensen, Abraham Stijn Meijnikman, Louise Elisabeth Olofsson, Dimitra Lappa, Ömrüm Aydin, Jens Nielsen, Victor Gerdes, Thomas Moritz, Arnold van de Laar, Maurits de Brauw, Max Nieuwdorp, Siv Annegrethe Hjorth, Thue Walter Schwartz, Fredrik Bäckhed
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105683- (2022)
Summary: Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells
Externí odkaz:
https://doaj.org/article/d9959421ddb94ab2875da795adbdc0af
Autor:
Bogdan Mateescu, Jennifer C. Jones, Roger P. Alexander, Eric Alsop, Ji Yeong An, Mohammad Asghari, Alex Boomgarden, Laura Bouchareychas, Alfonso Cayota, Hsueh-Chia Chang, Al Charest, Daniel T. Chiu, Robert J. Coffey, Saumya Das, Peter De Hoff, Andrew deMello, Crislyn D’Souza-Schorey, David Elashoff, Kiarash R. Eliato, Jeffrey L. Franklin, David J. Galas, Mark B. Gerstein, Ionita H. Ghiran, David B. Go, Stephen Gould, Tristan R. Grogan, James N. Higginbotham, Florian Hladik, Tony Jun Huang, Xiaoye Huo, Elizabeth Hutchins, Dennis K. Jeppesen, Tijana Jovanovic-Talisman, Betty Y.S. Kim, Sung Kim, Kyoung-Mee Kim, Yong Kim, Robert R. Kitchen, Vaughan Knouse, Emily L. LaPlante, Carlito B. Lebrilla, L. James Lee, Kathleen M. Lennon, Guoping Li, Feng Li, Tieyi Li, Tao Liu, Zirui Liu, Adam L. Maddox, Kyle McCarthy, Bessie Meechoovet, Nalin Maniya, Yingchao Meng, Aleksandar Milosavljevic, Byoung-Hoon Min, Amber Morey, Martin Ng, John Nolan, Getulio P. De Oliveira Junior, Michael E. Paulaitis, Tuan Anh Phu, Robert L. Raffai, Eduardo Reátegui, Matthew E. Roth, David A. Routenberg, Joel Rozowsky, Joseph Rufo, Satyajyoti Senapati, Sigal Shachar, Himani Sharma, Anil K. Sood, Stavros Stavrakis, Alessandra Stürchler, Muneesh Tewari, Juan P. Tosar, Alexander K. Tucker-Schwartz, Andrey Turchinovich, Nedyalka Valkov, Kendall Van Keuren-Jensen, Kasey C. Vickers, Lucia Vojtech, Wyatt N. Vreeland, Ceming Wang, Kai Wang, ZeYu Wang, Joshua A. Welsh, Kenneth W. Witwer, David T.W. Wong, Jianping Xia, Ya-Hong Xie, Kaichun Yang, Mikołaj P. Zaborowski, Chenguang Zhang, Qin Zhang, Angela M. Zivkovic, Louise C. Laurent
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104653- (2022)
Summary: The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the progr
Externí odkaz:
https://doaj.org/article/d72ed055b3ab4740b73e722d85b82959
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101371- (2022)
Summary: DNA fiber combing is a versatile technique that provides insight into replication fork dynamics at single-molecule resolution. DNA fibers are bound to silanized coverslips and combed, which straightens and aligns the fibers along a single ax
Externí odkaz:
https://doaj.org/article/c2b4045daf9542c28af06841e6cfb5ae