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Autor:
Yasuko Orba, William W. Hall, Shinsuke Toba, Takao Sanaki, Kentaro Uemura, Hirofumi Sawa, Akihiko Sato, Yukari Itakura, Koshiro Tabata, Kittiya Intaruck, Michihito Sasaki, Mai Kishimoto
Publikováno v:
Biochemical and Biophysical Research Communications
The human lung cell A549 is susceptible to infection with a number of respiratory viruses. However, A549 cells are resistant to Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection in conventional submerged culture, and this would a
Autor:
Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli, Antonella Tosoni, Manuela Nebuloni, Jeanette A.M. Maier
Despite remaining the best in vitro model to resemble the human brain, a weakness of human cerebral organoids is the lack of the endothelial component that in vivo organizes in the blood brain barrier (BBB). Since the BBB is crucial to control the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31ac66321751404c5ab085e1848ee90
https://hdl.handle.net/2434/939480
https://hdl.handle.net/2434/939480
Publikováno v:
Biochemical and biophysical research communications. 560:1-6
Cancer immunotherapy, especially treatment with monoclonal antibodies (mAbs) that block programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling, has attracted attention as a new therapeutic option for cancer. However, only a l
Autor:
Ryo Miyamoto, Takashi Kumasaka, Shigeyuki Matsumoto, Tohru Kataoka, Takashi Kawamura, Mitsugu Araki, Fumi Shima, Haruka Taniguchi-Tamura, Chiemi Tsuda, Yasushi Okuno
Publikováno v:
Biochemical and Biophysical Research Communications. 565:85-90
GTP-bound forms of Ras proteins (Ras•GTP) assume two interconverting conformations, "inactive" state 1 and "active" state 2. Our previous study on the crystal structure of the state 1 conformation of H-Ras in complex with guanosine 5'-(β, γ-imido
Autor:
Diana Iulia Savu, Nicoleta Moisoi
open access article Mitochondria - nuclear coadaptation has been central to eukaryotic evolution. The dynamic dialogue between the two compartments within the context of multiorganellar interactions is critical for maintaining cellular homeostasis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f620e43ef093c0ef2ff89ebc96e6b2
https://hdl.handle.net/2086/22098
https://hdl.handle.net/2086/22098
Autor:
Silva, Sandra G., Pinheiro, Marina, Pereira, Rui, Dias, Ana Rita, Ferraz, Ricardo, Prudêncio, Cristina, Eaton, Peter J., Reis, Salette, Vale, M. Luísa C. do
The antimicrobial activity of two serine derived gemini cationic surfactants, amide (12Ser)2CON12 and ester (12Ser)2COO12, was tested using sensitive, E. coli ATCC 25922 and S. aureus ATCC 6538, and resistant, E. coli CTX M2, E. coli TEM CTX M9 and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e673493c4a2365c5f263499aa96479
https://hdl.handle.net/10400.22/20583
https://hdl.handle.net/10400.22/20583
Publikováno v:
Biochemical and Biophysical Research Communications. 543:15-22
Oncogenic transformation enables cells to behave differently from their neighboring normal cells. Both cancer and normal cells recognize each other, often promoting the extrusion of the former from the epithelial cell layer. Here, we show that RasV12
Hepatic encephalopathy (HE) is a decline in brain function arising due to liver insufficiency. The liver's diminished capacity to clear ammonia, and the subsequent accumulation of it, is highly implicated in pathogenesis of HE. Ammonia is endogenousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bceae75c63cf3946a7488634aa9d169
https://doi.org/10.1016/j.ab.2022.114696
https://doi.org/10.1016/j.ab.2022.114696
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101113-(2022)
STAR Protocols
STAR Protocols
Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant posttranslational modification involved in a wide range of signaling pathways, but its specific role in regulating biological processes remains unclear. This protocol describes approac
Autor:
Kamal Badiani, L.H.G. Morton, Subrayal M. Reddy, David A. Phoenix, Sarah R. Dennison, Frederick Harris
Aurein 2.1, aurein 2.6 and aurein 3.1 are amphibian host defence peptides that kill bacteria via the use of lytic amphiphilic α-helical structures. The C-terminal PEGylation of these peptides led to decreased antibacterial activity (Minimum Lethal C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63971acfd050da143d9c58106c34a518