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of 285
pro vyhledávání: ''
Autor:
Kamal Badiani, L.H.G. Morton, Subrayal M. Reddy, David A. Phoenix, Sarah R. Dennison, Frederick Harris
Aurein 2.1, aurein 2.6 and aurein 3.1 are amphibian host defence peptides that kill bacteria via the use of lytic amphiphilic α-helical structures. The C-terminal PEGylation of these peptides led to decreased antibacterial activity (Minimum Lethal C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63971acfd050da143d9c58106c34a518
Autor:
Matthew J. Dalby, Mark Robert Sprott, Yinbo Xiao, Vineetha Jayawarna, Angela H. Nobbs, Peifeng Li, Virginia Llopis Hernandez, R. M. Dominic Meek, Peter G. Childs, Karl Burgess, Mark Ginty, Laila A. Damiati, Bo Su, Monica P. Tsimbouri, Manuel Salmerón-Sánchez, Julia Wells, Richard O.C. Oreffo, Gordon Ramage
Publikováno v:
Damiati, L, Tsimbouri, M, Hernandez, V L, Jayawarna, V, Ginty, M, Childs, P, Xiao, Y, Burgess, K E V, Wells, J, Sprott, M R, Meek, R M D, Li, P, Oreffo, R O C, Nobbs, A H, Ramage, G, Su, B, Salmeron-Sanchez, M & Dalby, M J 2022, ' Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation ', Biomaterials, vol. 280, 121263 . https://doi.org/10.1016/j.biomaterials.2021.121263
Post-operative infection is a major complication in patients recovering from orthopaedic surgery. As such, there is a clinical need to develop biomaterials for use in regenerative surgery that can promote mesenchymal stem cell (MSC) osteospecific dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff17f09d50e9ee9c0d8290dc016bf54
https://eprints.gla.ac.uk/258932/1/258932.pdf
https://eprints.gla.ac.uk/258932/1/258932.pdf
Mitochondria is a unique cellular organelle involved in multiple cellular processes and is critical for maintaining cellular homeostasis. This semi-autonomous organelle contains its circular genome - mtDNA (mitochondrial DNA), that undergoes continuo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13431c4c9bafd58ba6606cb94166abac
https://eprints.lincoln.ac.uk/id/eprint/48716/1/1-s2.0-S0005272822000238-main.pdf
https://eprints.lincoln.ac.uk/id/eprint/48716/1/1-s2.0-S0005272822000238-main.pdf
Autor:
Peihang Fang, Junjun Ding, Haopeng Yu, Junyi Sun, Jun Sun, Qi Tian, Yangyinhui Yu, Qian Ma, Jiahao Chen, Jia Wang
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100887-(2021)
STAR Protocols
STAR Protocols
Summary Phase separation of proteins regulates transcription. Here, we present a protocol to manipulate phase separation capacity of a protein. We use this protocol to disrupt phase separation by mutating residues at intrinsically disordered regions
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100959-(2021)
STAR Protocols
STAR Protocols
Summary This protocol provides instructions to track the global dynamics of single epigenetic regulatory factors in live cells. We describe an approach to generate cell lines that stably express HaloTag-fused proteins. We then use live-cell single-mo
Autor:
Tatsuo Hata, Akira Horii, Shinichi Fukushige, Kanchan Chakma, Fuyuhiko Motoi, Yakefujiang Abudurexiti, Zhaodi Gu, Michiaki Unno
Publikováno v:
Biochemical and Biophysical Research Communications. 526(3):626-632
Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. DNA methylation-mediated silenced genes in pancreatic cancer were searched for using the methyl-CpG targeted transcriptional activation (Me
Autor:
Hong-Lin Chan, Yu-Chun Lin, Chun Yao Wu, Chien-Wen Chang, Ching Hsiang Fan, Yi Ju Ho, Rih Yang Huang, Chih-Kuang Yeh, En Chi Liao, Ying-Zu Huang, Tsung Hsun Hsieh
Publikováno v:
Brain Stimulation, Vol 13, Iss 3, Pp 786-799 (2020)
Background Non-virus genetic treatment for Parkinson’s disease (PD) via plasmid glial cell-line derived neurotrophic factor (pGDNF) has shown potential for repairing damaged dopaminergic neurons. However, development of this gene therapy is largely
Publikováno v:
SC30202003120027
NARO成果DBd
C30201912240002_7513
NARO成果DBd
C30201912240002_7513
Polymethoxylated flavones (PMFs) are naturally occurring compounds that have biological effects on many cell types. We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell lin
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 14, Iss 2, Pp 312-324 (2020)
Stem Cell Reports, Vol 14, Iss 2, Pp 312-324 (2020)
Summary Force measurements in ex vivo and engineered heart tissues are well established. Analysis of calcium transients (CaT) is complementary to force, and the combined analysis is meaningful to the study of cardiomyocyte biology and disease. This a
Autor:
Ewa Sitarska, Alba Diz-Muñoz
Publikováno v:
Current Opinion in Cell Biology
The cell surface is a mechanobiological unit that encompasses the plasma membrane, its interacting proteins, and the complex underlying cytoskeleton. Recently, attention has been directed to the mechanics of the plasma membrane, and in particular mem