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Autor:
Philipp B. Staber, Peter Bettelheim, Christian Sillaber, Gabriele Stefanzl, Dubravka Smiljkovic, Daniela Berger, Georg Greiner, Peter Valent, Karin Bauer, Wolfgang R. Sperr, Ana-Iris Schiefer, Susanne Gamperl, Ilse Schwarzinger, Renate Thalhammer, Gregor Hoermann, Paul Knöbl, Christoph Kornauth
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1183-1191 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
During progression of myeloid neoplasms, the basophil compartment may expand substantially and in some of these patients, a basophilic leukemia is diagnosed. In patients with Ph-chromosome+ chronic myeloid leukemia, acceleration of disease is typical
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 912-928 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Protein Disulfide Isomerase Family A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable of catalyzing protein folding and disulfide bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes i
Autor:
Vasantha Lakshmi Gali, Mingzhi Zhang, Xiaosheng Fang, Yong Li, Fredrick B. Hagemeister, Donna M. Weber, Sheeba K. Thomas, Hans C. Lee, Zijun Y. Xu-Monette, Dahlia Sano, Manman Deng, Robert Z. Orlowski, Ken H. Young, Feng Zhu, Yingjun Wang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 361-374 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Waldenström macroglobulinemia (WM) is a distinct type of indolent lymphoplasmacytic lymphoma (LPL) with a high frequency of MYD88L265P mutation. Treatment for WM/LPL is highly variable in clinic and ibrutinib (a Bruton tyrosine kinase inhibitor, BTK
Autor:
Yumiko Inui, Kimikazu Yakushijin, Keiji Kurata, Yoriko Noguchi, Katsuya Yamamoto, Hisayuki Matsumoto, Yuji Nakamachi, Mitsuhiro Ito, Hironobu Minami, Hiroshi Matsuoka, Jun Saegusa, Keiji Matsui, Yoko Okazaki
Publikováno v:
Cancer Genetics. 241:72-76
Acute myeloid leukemia (AML) with an inv(16)(p13q22) or t(16;16)(p13;q22) chromosomal abnormality represents one of the most common subtypes of de novo cases. These chromosomal rearrangements result in multiple CBFB-MYH11 fusion transcripts, with typ
Autor:
Yiping Zhang, Qingyu Luo, Xiaowei Wu, Pengfei Zhao, Wan Chang, Zhihua Liu, Dan Su, Yabing Nan
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 98-111.e5 (2020)
Summary: Squamous cell carcinoma (SCC) is an aggressive epithelial malignancy, yet the molecular mechanisms underlying SCC development are elusive. ARID1A is frequently mutated in various cancer types, but both mutation rates and expression levels of
Autor:
Masaru Suzuki, Satoshi Oizumi, Eiki Kikuchi, Kenya Kanazawa, Hisashi Tanaka, Kaoruko Shimizu, Hiroshi Yokouchi, Ryoichi Honda, Toshiyuki Harada, Hajime Asahina, Tomoo Ikari, Kei Takamura, Tetsuya Kojima, Masao Harada, Yuka Fujita, Hiroshi Isobe, Hirotoshi Dosaka-Akita, Takahiro Ogi, Masaharu Nishimura, Fumiko Sugaya, Satoshi Konno
Publikováno v:
Lung cancer. 138:65-71
Objectives Patients with concomitant advanced non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD) are excluded from most clinical chemotherapy trials because of the high risk of exacerbating the latter condition. This study prospec
Autor:
Anudeep Yekula, Elizabeth Lansbury, Scott Mordecai, Fred H. Hochberg, Leonora Balaj, Bethany Delcuze, Julia L. Small, Pamela S. Jones, John Tigges, Alain Charest, Caroline M. Ayinon, Bob S. Carter, Ionita Ghiran
Publikováno v:
EBioMedicine, Vol 48, Iss, Pp 23-35 (2019)
EBioMedicine
EBioMedicine
Summary: Background: Malignant gliomas are rapidly progressive brain tumors with high mortality. Fluorescence guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) provides fluorescent delineation of malignant tissue, which helps achieve maximum sa
Publikováno v:
ESMO Open
Primary diffuse large B-cell (DLBCL) lymphoma of the central nervous system (CNS) (PCNSL) is a new lymphoma entity, recognized by the 2017 WHO classification of hematopoietic and lymphoid tumors. Unlike systemic DLBCL, the use of anthracycline-based
Autor:
Takuji Tanaka, Hiroyuki Tomita, Ayumi Niwa, Akira Hara, Kei Noguchi, Natsuko Suzui, Hisashi Imai, Hideshi Okada, Shigeyuki Sugie, Haruhiko Akiyama, Akihiro Hirata, Kaori Tanaka, Kazuhiro Yoshida, Yohei Shirakami, Tatsuhiko Miyazaki, Yuichiro Hatano, Masahito Shimizu, Tomohiro Kanayama, Kotaro Ohnishi, Hitomi Aoki
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108772-(2021)
Summary Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type of precancerous lesion of cholangiocarcinoma is limited. Moreover, a reproducible in vivo model is lacking, and IPNB pathogenesis remains unclear. Here, we us
Autor:
Laura Wormser, Claus Hellerbrand, Anja-Katrin Bosserhoff, Valerie Fritz, Peter Dietrich, Anne Gaza
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 3, Pp 257-268 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Inhibition of the RAS-RAF-ERK-pathway using sorafenib as a first-line and regorafenib as a second-line treatment approach is the only effective therapeutic strategy for advanced hepatocellular carcinoma (HCC). Recent studies suggest that wild-type KR