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Autor:
Laura Wormser, Claus Hellerbrand, Anja-Katrin Bosserhoff, Valerie Fritz, Peter Dietrich, Anne Gaza
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 3, Pp 257-268 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Inhibition of the RAS-RAF-ERK-pathway using sorafenib as a first-line and regorafenib as a second-line treatment approach is the only effective therapeutic strategy for advanced hepatocellular carcinoma (HCC). Recent studies suggest that wild-type KR
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss, Pp 111089-(2021)
Osteoarthritis is a chronic, systemic and inflammatory disease. However, the pathogenesis and understanding of RA are still limited. Ubiquitin-specific protease 13 (USP13) belongs to the deubiquitinating enzyme (DUB) superfamily, and has been implica
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 121, Iss, Pp 109607-(2020)
Long non-coding RNAs (lncRNAs) highly upregulated in liver cancer (HULC) has been identified as an oncogene involved in many human cancers. Herein, we aimed to further explore the role and molecular mechanism of HULC in gastric cancer (GC) progressio
Autor:
Jun Yokota, Curtis C. Harris, Motonobu Saito, Momoyo Nishida, Naoto Tsuchiya, Ana I. Robles, Masatoshi Watanabe, Takashi Kohno, Yuko Fujiwara, Takahiro Ochiya, Fumitaka Takeshita
Publikováno v:
EBioMedicine
Background Activation of intrinsic p53 tumor-suppressor (TS) pathways is an important principle underlying cancer chemotherapy. It is necessary to elucidate the precise regulatory mechanisms of these networks to create new treatment strategies. Metho
Autor:
Junlin Chi, Shuang Liu, Yujian Zeng, Huayou Luo, Tonglei Liu, Binghong Xiong, Chengmin Shi, Zhizhong Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 118, Iss, Pp-(2019)
Purpose The aim of this study was to research the function of lncRNA LUCAT1 in gastric cancer. Methods Human gastric cancer tissues and paracancer tissues were obtained from 98 patients undergoing surgical resection in our hospital. The human gastric
Autor:
Rong Kong, Zhao-Qun Deng, De-Hong Wu, Ji-chun Ma, Xin Zhu, Hong‐chun Qiu, Yun-Yun Yi, Jing Yi, Jiang Lin, Jun Qian
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 112, Iss, Pp-(2019)
Dysregulation of miR-378 has been found in diverse types of tumors as well as in leukemia. The role of miR-378 in chronic myeloid leukemia (CML) remains unclear. The aim of the study was to reveal the potential effects of miR-378 in the pathological
Autor:
Fabio Cherubini, Veronica De Simone, Carmine Stolfi, Davide Di Fusco, Angela Ortenzi, Federica Laudisi, Ivan Monteleone, Eleonora Franzè, Antonio Di Grazia, Eric R. Fearon, Giovanni Monteleone, Vincenzo Dinallo, Alfredo Colantoni
Colorectal cancer (CRC) remains one of the leading causes of mortality worldwide. Drug repositioning is a promising approach for new cancer therapies, as it provides the opportunity to rapidly advance potentially promising agents into clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67626f4978aa2412475821f43ea99c2
http://hdl.handle.net/2108/225002
http://hdl.handle.net/2108/225002