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Autor:
Jing Ma, Di Yu, Anna Dimberg, Minttu-Maria Martikainen, Mohanraj Ramachandran, Miika Martikainen, Andres Merits, Roberta Lugano, Magnus Essand
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 37-46 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Oncolytic virotherapy holds promise of effective immunotherapy against otherwise nonresponsive cancers such as glioblastoma. Our previous findings have shown that although oncolytic Semliki Forest virus (SFV) is effective against various mouse gliobl
Autor:
Khalid Saad Alharbi, Lin Sun, Mingyun Wen, Adel F. Alghaith, Majed Alrobaian, Waleed H. Almalki, Fahad A. Al-Abbasi, Youchun Tan, Obaid Afzal, Mahfoozur Rahman, Sattam Khulaif Alenezi, Bin Wang, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Sarwar Beg, Hanadi A. Katouah
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 29, Iss 8, Pp 843-856 (2021)
Saudi Pharmaceutical Journal, Vol 29, Iss 8, Pp 843-856 (2021)
The current study focuses on the development and evaluation of nano lipidic carriers (NLCs) for codelivery of sorafenib (SRF) and ganoderic acid (GA) therapy in order to treat hepatocellular carcinoma (HCC). The dual drug-loaded NLCs were prepared by
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 658-668 (2021)
Hemophilia A is a hemorrhagic disease due to congenital deficiencies of coagulation factor VIII (FVIII). Studies show that hemophilia patients with anticoagulant deficiency present less severe hemorrhagic phenotypes. We aimed to find a new therapeuti
Publikováno v:
Breast, Vol 57, Iss, Pp 18-24 (2021)
The Breast : Official Journal of the European Society of Mastology
The Breast : Official Journal of the European Society of Mastology
Objective To compare the real-world effectiveness and costs of eribulin to those of capecitabine in patients with metastatic breast cancer (MBC) pretreated with anthracyclines and taxanes. Methods This study extracted data from the Health and Welfare
Autor:
Chia-An Chou, Chien-Hsing Wu, Lo-Hsin Dai, Jien-Wei Liu, Hsuan-An Su, Chien-Te Lee, Chih-Chao Yang
Publikováno v:
Journal of the Formosan Medical Association, Vol 120, Iss 6, Pp 1350-1360 (2021)
Background: Identification and treatment for latent tuberculosis infection (LTBI) are of great epidemiological importance of controlling tuberculosis (TB) worldwide. Identification in high-risk population on dialysis and treatment with 12-week weekly
Autor:
Ram V Nampoothiri, Neelam Varma, Savita Verma Attri, Pankaj Malhotra, Subhash Varma, Arihant Jain, Gaurav Prakash, Deepesh Lad, Amol N Patil, Alka Khadwal, Samir Malhotra, Kripa Shanker Kasudhan
Publikováno v:
Hematology/Oncology and Stem Cell Therapy, Vol 14, Iss 2, Pp 114-118 (2021)
Background: Most data on autologous hematopoietic cell transplantation (auto-HCT) in myeloma are based on the use of innovator formulation of melphalan. Comparative bioequivalence and efficacy studies of generic melphalan are lacking. Methods: In thi
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic
Autor:
Rita De Sanctis, Federica D'Antonio, Elisa Agostinetto, Arianna Marinello, Giovanna Masci, Daniela Guiducci, Armando Santoro, Agnese Losurdo, Laura Giordano, Monica Zuradelli, Rosalba Torrisi
Publikováno v:
Breast, Vol 57, Iss, Pp 80-85 (2021)
The Breast : Official Journal of the European Society of Mastology
The Breast : Official Journal of the European Society of Mastology
Background Few data are available about real-life cardiotoxicity associated with s.c. versus i.v. trastuzumab treatment of early-stage, HER2-positive breast cancer, and little is known about its predisposing factors. Patients and methods We retrospec
Autor:
Hussein Alhindas, Abdullah H. Alomrani, Fulwah Yahya Alqahtani, Lamyaa Albakr, Fadilah Sfouq Aleanizy, Futwan Al-Mohanna, Mohammad Badran
Publikováno v:
Saudi Pharmaceutical Journal, Vol 29, Iss 5, Pp 446-455 (2021)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Nowadays, microRNA is considered an attractive strategy for the effective treatment of cancer. A significant delivery of microRNA for cancer therapy remains a significant obstacle to target cancer cells. The restoring microRNA-1296 (miR-1296) has imm
Autor:
Yaguang Xi, Bin Yi, Ches’Nique M. Phillips, Zhipin Liang, Hongyou Zhao, Hui-Yi Lin, Adam I. Riker
Publikováno v:
Genes and Diseases, Vol 8, Iss 3, Pp 320-330 (2021)
Genes & Diseases
Genes & Diseases
Sulindac has shown significant clinical benefit in preventing colorectal cancer progression, but its mechanism of action has not been fully elucidated. We have found that sulindac sulfide (SS) is able to inhibit cell cycle progression in human colore