Zobrazeno 71 - 80
of 6 364
pro vyhledávání: ''
Autor:
Konstantin Dobrenkov, Vladimir Ponomarev, Jason T. Lee, Ronald G. Blasberg, Ekaterina Nikolov, Maxim A. Moroz, Inna Serganova, Yury Likar, Anna Moroz, Juan Zurita, Larissa Shenker
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 15-22 (2021)
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals. We introduced and characterized a novel bioluminesce
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 329-339 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Acute lymphoblastic leukemia (ALL) is an aggressive hematological neoplasm resulting from immature lymphoid precursors. An antibody-drug conjugate (ADC), coupling a small molecule covalently with a targeting antibody, can specifically kill tumor cell
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1240-1247 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1240-1247 (2021)
Graphical abstract
Highlights • DMSO impacts on C. elegans feeding behaviour in short-term and in a reversible manner. • DMSO affects the cellular integrity of C. elegans. • nlg-1 mutant is refractory to DMSO induced pumping inhibition.
Highlights • DMSO impacts on C. elegans feeding behaviour in short-term and in a reversible manner. • DMSO affects the cellular integrity of C. elegans. • nlg-1 mutant is refractory to DMSO induced pumping inhibition.
Autor:
Yuliya Lytvyn, Vikas S. Sridhar, David Z.I. Cherney, Patrick R. Lawler, Kevin D. Burns, Davor Brinc, Hongyan Liu, Dylan Burger, Leif E. Lovblom
Publikováno v:
Kidney International Reports
Introduction Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve cardiovascular and kidney outcomes through mechanisms that are incompletely understood. In this exploratory post-hoc analysis of the VERTIS RENAL trial, we report the association
Autor:
Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients express mutant isocitrate dehydrogenase 2 (mIDH2), which leads to the ac
Autor:
Yan Jiang, Xiaolin Ni, Toshio Matsumoto, Li Zhang, Ou Wang, Weibo Xia, Juan Feng, Xiaoping Xing, Mei Li, Wei Yu
Publikováno v:
Osteoporosis and Sarcopenia, Vol 7, Iss 2, Pp 47-53 (2021)
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia
Objectives To compare the effect of eldecalcitol and alfacalcidol on skeletal microstructure by high-resolution peripheral QCT (HR-pQCT). Methods This was a substudy of a randomized, double-blind, active comparator trial. Five female osteoporotic pat
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 6, Pp 551-560 (2021)
Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant
Autor:
Victor Ramos, Kerry D. Fisher, Claudia Hill, Robert Carlisle, Constantin C. Coussios, Len Seymour, Luca Bau, Joel Balkaran, Megan Grundy, Sheena Wallington
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 47-61 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is be
Autor:
Clara Duran, Aurélien Dinh, Thomas W. Bauer, Marine de Laroche, Claire Rempenault, Elsa Salomon, Frédérique Bouchand, Morgan Matt, Valentine Pagis, Simona Berbescu, Latifa Noussair, Benjamin Davido, Martin Rottman, Christophe Nich
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 25, Iss, Pp 282-286 (2021)
Background . Ceftazidime/Avibactam (C/A) and Ceftolozane/Tazobactam (C/T) are two novel antibacterial agents with a known efficacy on Gram-negative bacteria (GNB). Objectives . We aimed to describe the efficacy and safety of surgical management combi