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Autor:
Yu-Yang Li, Mengxiao He, Hao-Yang Wang, Weiyan Meng, Baosheng Li, Yu-Jie Liu, Yanqun Liu, Yidan Sun
Publikováno v:
Journal of Dental Sciences, Vol 16, Iss 4, Pp 1255-1263 (2021)
Journal of Dental Sciences
Journal of Dental Sciences
Background/purpose: Pyroptosis is a form of programmed cell death dependent on the activation of caspase-1. Porphyromonas gingivalis (P. gingivalis) is a major pathogenic bacterium in periodontitis and its lipopolysaccharide (LPS) can trigger inflamm
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3193-3205 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (5) as an effective necroptosis inh
Autor:
Jun Morinaga, Kimio Tomita, Yuichiro Izumi, Yasunobu Iwata, Teruhiko Mizumoto, Masashi Mukoyama, Yutaka Kakizoe, Takashige Kuwabara, Qinyuan Deng, Yoshiki Sakai, Terumasa Nakagawa, Yoshikazu Miyasato, Taku Miyoshi, Manabu Hayata, Kohei Uchimura, Kenichiro Kitamura, Masataka Adachi
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 192-199 (2021)
Metabolic syndrome (MetS) is associated with chronic kidney disease and proteinuria. Previously, we reported that a synthetic serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent disease models. The pres
Autor:
Sonoko Harada, Hitoshi Sasano, Tomohito Takeshige, Kazuhisa Takahashi, Fumihiko Makino, Ayako Ishimori, Hisaya Akiba, Jun Ito, Yuuki Sandhu, Kei Matsuno, Ryo Atsuta, Yoko Katsura, Norihiro Harada
Publikováno v:
Allergology International, Vol 70, Iss 3, Pp 343-350 (2021)
Background Previous reports have shown that pathogen-associated patterns (PAMPs) induce the production of interleukin (IL)-1β in macrophages. Moreover, studies using mouse models also suggest that chitin, which acts as a PAMP, induces adjuvant effec
Autor:
Andreas V. Goules, Smaragdi Marinaki, Sophia Fragkioudaki, Athanasios G. Tzioufas, Petros Kalogeropoulos, John Boletis, George Liapis, Emmanuel Kalaitzakis, Ioannis Michelakis, Sophia Lionaki
Publikováno v:
Kidney International Reports
Introduction Recent evidence suggests that complement activation is important in the pathogenesis of pauci-immune (PI) vasculitis. This is a retrospective investigation of the frequency of hypocomplementemia at pauci-immune glomerulonephritis (PIGN)
Publikováno v:
Journal of Traditional Chinese Medical Sciences, Vol 8, Iss 2, Pp 161-165 (2021)
Background Inflammation is an essential component of liver diseases. Paeoniflorin (PF), a monoterpenoid component derived from peony root (Paeonia lactiflora Pall.), has anti-inflammatory, immunoregulatory, and hepatoprotective activities. However, w
Autor:
Fatima K. Alshahrani, Mervat Mahrous, Medina A. Ahmed, Ghadah Almutiri, Fatehi Elzein, Eid Alsufyani, Ahmed Ibrahim, Meshal Altowairqi, Esam Murshid, Nouf Alnawshan, Mohammed Alsaeed, Turki Aldhehyan
Publikováno v:
Journal of Infection and Public Health, Vol 14, Iss 4, Pp 474-477 (2021)
Journal of Infection and Public Health
Journal of Infection and Public Health
Background Severe acute respiratory syndrome coronavirus 2 (SARS-cov-2), first described in December 2019, has now infected more than 28 million cases with almost one million deaths. Reinfection is not definitely established however disease recurrenc
Autor:
Toshiyuki Kawashima, Kenichi Ishibashi, Naohiro Tsuyuguchi, Takehiro Uda, Yuta Tanoue, Hiroshi Uda, Takeo Goto, Atsufumi Nagahama, Yuzo Terakawa, Kosuke Nakajo, Tsuyoshi Sasaki, Saya Koh, Yonehiro Kanemura, Kenji Ohata
Publikováno v:
World Neurosurgery. 148:e471-e481
Background The relationship between uptake of amino acid tracer with positron emission tomography (PET) and glioma subtypes/gene status is still unclear. Objective To assess the relationship between uptake of [11C]methionine using PET and pathology,
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 2, Pp 133-140 (2021)
Hematology, Transfusion and Cell Therapy
Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 2, Pages: 133-140, Published: 07 JUL 2021
Hematology, Transfusion and Cell Therapy
Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 2, Pages: 133-140, Published: 07 JUL 2021
Background Carica papaya Linn. has high nutraceutical and pharmacological values. The leaves possess antimicrobial, anti-tumor and antioxidant properties. They are used to treat thrombocytopenia during dengue fever and the leaf extract is commerciall
Autor:
Antonietta Rossi, Tran Hung, Oliver Werz, Christina Weinigel, Rossella Bilancia, Birgit Waltenberger, Zhigang Rao, Veronika Temml, Hermann Stuppner, Christian Kretzer, Carsten Giesel, Andreas Koeberle, Stefan Schwaiger, Silke Rummler, Alilou Mostafa, Tran Thi Van Anh, Paul M. Jordan, Simona Pace
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolv