Zobrazeno 1 - 10
of 415
pro vyhledávání: ''
Publikováno v:
Genes and Diseases, Vol 9, Iss 2, Pp 334-346 (2022)
Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron dependency and lipid peroxidation, is involved in many pathological conditions such as neurodegenerative diseases, heart ischemia/reperfusion injury, acute renal fai
Autor:
Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). Thi
Autor:
Xiufu Lan, Jinzhi Wang, Zhaobo Cheng, Liu Yi, Qin Xiang, Hongbin Zhang, Yan Wang, Yun Xiao, Tingxiu Xiang, Li Chao, Jixiang Song, Ping Ju, Shu Zhang, Benxu Tan, Zheng Fu, Jian Zhang, Ke Xu, Lijuan Zhao
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 151-164 (2022)
Genes & Diseases
Genes & Diseases
This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma (HCC), further, to explore the effect of LPCAT1 on overall survival (OS) in patients with HCC, and its possible m
Autor:
Konstantin Dobrenkov, Vladimir Ponomarev, Jason T. Lee, Ronald G. Blasberg, Ekaterina Nikolov, Maxim A. Moroz, Inna Serganova, Yury Likar, Anna Moroz, Juan Zurita, Larissa Shenker
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 15-22 (2021)
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals. We introduced and characterized a novel bioluminesce
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 329-339 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Acute lymphoblastic leukemia (ALL) is an aggressive hematological neoplasm resulting from immature lymphoid precursors. An antibody-drug conjugate (ADC), coupling a small molecule covalently with a targeting antibody, can specifically kill tumor cell
Autor:
Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients express mutant isocitrate dehydrogenase 2 (mIDH2), which leads to the ac
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 6, Pp 551-560 (2021)
Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant
Autor:
Victor Ramos, Kerry D. Fisher, Claudia Hill, Robert Carlisle, Constantin C. Coussios, Len Seymour, Luca Bau, Joel Balkaran, Megan Grundy, Sheena Wallington
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 47-61 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is be
Autor:
Zan Song, De-Quan Yu, Hong-Min Liu, Wang Wang, Yu Ke, Xu-Bin Ma, Ying Liu, Yajie Liu, Yi-Chao Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1513-1525 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation, thus stimulating ferroptosis may be a potential strategy for treating gastric cancer, therapeutic agents against which are urgently required. Jiyuan oridonin A (JDA
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 610-621 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and angiogenesis plays critical roles in its recurrence and metastasis. In this study, we investigated the effects of hypoxia-induced exosomal microRNA-181 (miR-181a) from PTC