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Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 2, Pp 202-212 (2021)
Acute lung injury (ALI), a common complication of sepsis, is characterized by the impairment and injury of pulmonary function. The nuclear factor kappa-B (NF-κB) pathway is activated in ALI. Tripartite motif-containing 37 (TRIM37) can activate the N
Autor:
Branka I. Ognjanović, Biljana Božić Nedeljković, Emilija Marinković, Bojan Đ. Božić, Miloš M. Matić, Predrag Đurđević, Ana Obradović, Gordana S. Ušćumlić
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 3, Pp 246-254 (2020)
Saudi Pharmaceutical Journal
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal
Saudi Pharmaceutical Journal : SPJ
In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivat
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 4, Pp 387-396 (2020)
Saudi Pharmaceutical Journal, Vol 28, Iss 4, Pp 387-396 (2020)
Tumor cells overexpress low-density lipoprotein (LDL) receptors (LDL-r). Hence, LDL is proposed as a targeting shuttle of anticancer drugs. Therefore, the objective of this study was to synthesize a dual inhibitor of heat shock protein 27 (HSP27) and
Autor:
Concettina La Motta, Melania Gaggini, Rocchina Colucci, Serena Del Turco, Luca Quattrini, Giuseppina Basta
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1174-1181 (2019)
Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1174-1181 (2019)
Low-grade chronic inflammation is a key process of angiogenesis in tumour progression. We investigated whether a synthetic analogue of apigenin, the 2-(3,4-dimethoxyphenyl)-3-phenyl-4H-pyrido[1,2-a] pyrimidin-4-one (called DB103), interfered with the
Autor:
Zhi-Ping Jiang, Wei Zhang, Fang Yuan, Gan Zhou, Cao Shan, Cong Cheng, Xie-Lan Zhao, Hong-Hao Zhou, Xiao-Ping Chen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111652-(2021)
Chemotherapy resistance remains to be the primary barrier to acute myeloid leukemia (AML) treatment failure. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been well established as a truly pleiotropic transcription factor. Inhibition of Nrf2
Autor:
Seidamir Pasha Tabaeian, Abolfazl Akbari, Ana Beatriz Pizarro, Zahra Rostami, Javad Heshmati, Meghdad Sedaghat, Sadegh Dehghani, Shahram Agah
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111849-(2021)
Curcumin is a bioactive ingredient found in the Rhizomes of Curcuma longa. Curcumin is well known for its chemopreventive and anti-cancer properties. Recent findings have demonstrated several pharmacological and biological impacts of curcumin, relate
Autor:
Milad Ashrafizadeh, Amir Reza Aref, Farid Hashemi, Seyed Omid Sharifzadeh, Leyla Soleymani, Hossein Saleki, Sepideh Mirzaei, Saeed Samarghandian, Haroon Khan, Amirhossein Zabolian, Ali Zarrabi, Alan Prem Kumar, Kiavash Hushmandi, Salman Daneshi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111824-(2021)
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells are transformed to mesenchymal cells, and at molecular level, E-cadhe
Autor:
Balaji Hari, Agnieszka Najda, Chenmala Karthika, Mohamed M. Abdel-Daim, Rokeya Akter, Md. Habibur Rahman, Muhammad Furqan Akhtar, Amany A. Sayed, Ghadeer M. Albadrani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111704-(2021)
Cancer treatment is improving widely over time, but finding a proper defender to beat them seems like a distant dream. The quest for identification and discovery of drugs with an effective action is still a vital work. The role of a membrane protein
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111565-(2021)
Ceramides, the core of the sphingolipid metabolism, draw wide attention as tumor suppressor, and act directly on mitochondria to trigger apoptotic cell death. Ceramide-based therapies are being developed by using promote ceramide generating agents. T
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111658-(2021)
According to recent statistics, Lung Cancer (LC) is one of the most frequently diagnosed tumor types, representing nearly 12% of all global cancer cases. Moreover, in recent years, an increased mortality rate and incidence of this cancer were observe