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Publikováno v:
Genes and Diseases, Vol 9, Iss 2, Pp 334-346 (2022)
Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron dependency and lipid peroxidation, is involved in many pathological conditions such as neurodegenerative diseases, heart ischemia/reperfusion injury, acute renal fai
Autor:
Xiufu Lan, Jinzhi Wang, Zhaobo Cheng, Liu Yi, Qin Xiang, Hongbin Zhang, Yan Wang, Yun Xiao, Tingxiu Xiang, Li Chao, Jixiang Song, Ping Ju, Shu Zhang, Benxu Tan, Zheng Fu, Jian Zhang, Ke Xu, Lijuan Zhao
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 151-164 (2022)
Genes & Diseases
Genes & Diseases
This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma (HCC), further, to explore the effect of LPCAT1 on overall survival (OS) in patients with HCC, and its possible m
Autor:
Konstantin Dobrenkov, Vladimir Ponomarev, Jason T. Lee, Ronald G. Blasberg, Ekaterina Nikolov, Maxim A. Moroz, Inna Serganova, Yury Likar, Anna Moroz, Juan Zurita, Larissa Shenker
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 15-22 (2021)
Bioluminescence reporter gene imaging is a robust, high-throughput imaging modality that is useful for tracking cells and monitoring biological processes, both in cell culture and in small animals. We introduced and characterized a novel bioluminesce
Autor:
Michael W. Drazer, Joshua G. Klein, Mortimer Poncz, Catriana C. Nations, Lucy A. Godley, Giulia Pavani, Deborah L. French, Rodney M. Camire, Jean Ann Maguire, Paul Gadue, Sara Borst
Publikováno v:
Stem Cell Reports
Summary Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of these patients have monoallelic germline mutations in ETV6 or RUNX1 and a heightened risk of developing hematologic malignancies. Utilizing CRISPR-Ca
Autor:
Ran Chen, Zhi Yang, Hailong Zhang, Yanli Wang, Shengfang Ge, Jianxiu Yu, Tianqi Liu, Jiayu Fang, Jian Huang, Xian Zhao
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 3, Pp 129-141 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Numerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway. Here, we report that c-Src can interact with and phos
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma
Autor:
Jonathan D. Smith, Varadharajan Venkaleshwari, Daniel J. Silver, Justin D. Lathia, Defne Bayik, Brian I. Rini, Chase K.A. Neumann, Renliang Zhang, C. Alicia Traughber, J. Mark Brown, Christopher G. Przybycin
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 136-145 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 136-145 (2020)
Objective: The most common kidney cancer, clear cell renal cell carcinoma (ccRCC), is closely associated with obesity. The “clear cell” variant of RCC gets its name from the large lipid droplets that accumulate in the tumor cells. Although renal
Autor:
Xin Ge, Meiling Lu, Xiang-Huan Cui, Shilin Xu, Danni Rao, Zhiqiang Li, Wenwen Tang, Ping Wang, Lei Yu, Xuemei Gu, Xin-Yan Chen, Hong-Bing Wang, Jing Wen
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101129-(2021)
Translational Oncology
Translational Oncology
Highlights • Interception of CD47-SIRPα signaling is an elusive yet intriguing goal for anti-tumor immunotherapy since unbiased CD47 blockade by its antibody cannot avoid erythrocyte destruction. • We previously reported that isoQC, a Golgi-resi
Publikováno v:
Stem Cell Research, Vol 53, Iss, Pp 102330-(2021)
Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessively inherited progressive retinal disease. Here, we describe the generation and characterization of a human induced pluripotent stem cell (hiPSC) line of BCD patient with CYP4V2
Autor:
Cheryl Rockman-Greenberg, Abhay Srivastava, Sanjiv Dhingra, Keshav Narayan Alagarsamy, Glen Lester Sequiera
Publikováno v:
Stem Cell Research, Vol 53, Iss, Pp 102283-(2021)
Kearns-Sayre syndrome (KSS) is an ultrarare multi-organ disorder, with a frequency of ~1 in 100,000 individuals. KSS is characterized with (1.1-10 kilobase) deletion of a mitochondrial DNA (mtDNA). We created an induced pluripotent stem cell (iPSC) l
Publikováno v:
Stem Cell Research, Vol 52, Iss, Pp 102229-(2021)
The ALDH2 mutation (ALDH2*2) is caused by an amino acid substitution ALDH2 rs671 G>A (pE487K) which reduces ALDH2 enzyme activity. When individuals with the ALDH2 mutation consume alcohol, accumulating acetaldehyde in the blood can cause reddened fac