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Publikováno v:
International Journal of Biological Macromolecules. 182:1130-1137
A soluble protein fraction from radish (Raphanus sativus L.) taproot had cryoprotective activity for lactate dehydrogenase (LDH). The activity was found mainly in the heat-stable fractions of soluble proteins. The cryoprotective protein, whose molecu
Autor:
S. G. Ghane, Suraj B. Patel
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 7, Pp 3835-3846 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Luffa echinata Roxb. is one of the neglected medicinal plants. It is an important source of bioactive metabolites and used in several Ayurvedic formulations. In the present analysis, mature leaves and fruits were extracted with acetone, ethanol, acet
Autor:
Magdy M. Awny, Hagar M. El-Sadek, Muhammad Y. Al-Shorbagy, Hanan S. El-Abhar, Dalaal M. Abdallah
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 3, Pp 136-148 (2021)
Despite the documented renoprotective effect of pentoxifylline (PTX), a non-selective phosphodiesterase-4 inhibitor, the studies appraised only its anti-inflammatory/-oxidant/-apoptotic capacities without assessment of the possible involved trajector
Autor:
Mohammed Alsaidan, Chandrabose Sureka, Khaled K. Aldossari, Abubucker Peer Mohideen, Thiyagarajan Ramesh, Sameer Al-Ghamdi, Mohamed A. Abdelaziz, Ayman Geddawy, Veerayan Elango
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 7, Pp 3669-3677 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
In diabetic condition, endogenous glucose synthesis will be elevated due to defect in the action of vital enzymes involved in carbohydrate metabolism, which is the main cause for hyperglycemia. The current study was designed to explore the anti-hyper
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2048-2058 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
A commercial albumin-bound paclitaxel nano-formulation has been considered a gold standard against breast cancer. However, its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier. Herein, we r
Autor:
Sonoko Harada, Hitoshi Sasano, Tomohito Takeshige, Kazuhisa Takahashi, Fumihiko Makino, Ayako Ishimori, Hisaya Akiba, Jun Ito, Yuuki Sandhu, Kei Matsuno, Ryo Atsuta, Yoko Katsura, Norihiro Harada
Publikováno v:
Allergology International, Vol 70, Iss 3, Pp 343-350 (2021)
Background Previous reports have shown that pathogen-associated patterns (PAMPs) induce the production of interleukin (IL)-1β in macrophages. Moreover, studies using mouse models also suggest that chitin, which acts as a PAMP, induces adjuvant effec
Autor:
Masakazu Shinohara, Makoto Imamori, Wataru Ogawa, Tetsuya Hosooka, Yusei Hosokawa, Kei Yoshino, Chikako Aoki
Publikováno v:
Biochemical and Biophysical Research Communications. 557:62-68
Clinical and animal studies have suggested a possible beneficial effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH). Although SGLT2 inhibitors have bee
Autor:
Ryo Miyamoto, Takashi Kumasaka, Shigeyuki Matsumoto, Tohru Kataoka, Takashi Kawamura, Mitsugu Araki, Fumi Shima, Haruka Taniguchi-Tamura, Chiemi Tsuda, Yasushi Okuno
Publikováno v:
Biochemical and Biophysical Research Communications. 565:85-90
GTP-bound forms of Ras proteins (Ras•GTP) assume two interconverting conformations, "inactive" state 1 and "active" state 2. Our previous study on the crystal structure of the state 1 conformation of H-Ras in complex with guanosine 5'-(β, γ-imido
Autor:
Meircurius Dwi Condro Surboyo, Elita Monica, Ira Arundina, Novitasari Mira Afanda, Indeswati Diyatri
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 16, Iss 3, Pp 431-439 (2021)
Journal of Taibah University Medical Sciences
Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: تتطلب عملية الشفاء من قرحة مؤلمة عوامل النمو لإعادة بناء الأنسجة المفقودة بعد الانتهاء من عملية الالتهاب. وقد أظهر د
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3193-3197 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
The main aim of this study was to evaluate the neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke model rats and its effect on extracellular regulated protein kinase 1/2 (REK1/2) signaling pathway, and to