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Autor:
Jun Morinaga, Kimio Tomita, Yuichiro Izumi, Yasunobu Iwata, Teruhiko Mizumoto, Masashi Mukoyama, Yutaka Kakizoe, Takashige Kuwabara, Qinyuan Deng, Yoshiki Sakai, Terumasa Nakagawa, Yoshikazu Miyasato, Taku Miyoshi, Manabu Hayata, Kohei Uchimura, Kenichiro Kitamura, Masataka Adachi
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 192-199 (2021)
Metabolic syndrome (MetS) is associated with chronic kidney disease and proteinuria. Previously, we reported that a synthetic serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent disease models. The pres
Autor:
Nora Abdullah AlFaris, Sultan Alqahtani, Dalal H. Aljabryn, Jozaa Zaidan ALTamimi, Mohammed A. Yahya, Hussain Aldera, Ghedeir M. Alshammari, Reham I. Alagal
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 8, Pp 4300-4310 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Diabetes mellitus induces testicular damage, increases sperm abnormalities, and impairs reproductive dysfunction due to induction of endocrine disturbance and testicular oxidative stress. This study evaluated the reproductive protective effect of ell
Autor:
Mohammed Alsaidan, Chandrabose Sureka, Khaled K. Aldossari, Abubucker Peer Mohideen, Thiyagarajan Ramesh, Sameer Al-Ghamdi, Mohamed A. Abdelaziz, Ayman Geddawy, Veerayan Elango
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 7, Pp 3669-3677 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
In diabetic condition, endogenous glucose synthesis will be elevated due to defect in the action of vital enzymes involved in carbohydrate metabolism, which is the main cause for hyperglycemia. The current study was designed to explore the anti-hyper
Autor:
Masakazu Shinohara, Makoto Imamori, Wataru Ogawa, Tetsuya Hosooka, Yusei Hosokawa, Kei Yoshino, Chikako Aoki
Publikováno v:
Biochemical and Biophysical Research Communications. 557:62-68
Clinical and animal studies have suggested a possible beneficial effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH). Although SGLT2 inhibitors have bee
Autor:
Areej A. Eskandrani
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3497-3504 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Ulcerative colitis (UC) is an inflammatory bowel disease with high morbidity. Acetic acid-induced damage of colonic mucosa in rats is a commonly used experimental animal model of UC. This research aimed to explore for the first time the ameliorative
Autor:
Mohammad Hossein Nazem Shirazi, Hosein Nourani, Amir Afkhami Goli, Nasrin Ramezani, Asieh Karimani, Amir Moghaddam Jafari
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1280-1288 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1280-1288 (2021)
Graphical abstract
Highlights • Diazinon perturbs CNS function via multiple mechanisms. • Oxidative stress is one of the main causes of diazinon-induced neurodegeneration. • Gene expression may be affected by diazinon exposure. • Diazino
Highlights • Diazinon perturbs CNS function via multiple mechanisms. • Oxidative stress is one of the main causes of diazinon-induced neurodegeneration. • Gene expression may be affected by diazinon exposure. • Diazino
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3448-3452 (2021)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Methionine (MET) rich diets, smoking, coffee and alcohol consumption, low physical activity, and aging are related to high plasma concentrations of homocysteine, which can jeopardize the heart health. Although hyperhomocysteinemia has been considered
Autor:
Arnaud Droit, Elvira Mass, Corey A. Scipione, Raphaëlle Bourgeois, Benoit J. Arsenault, Philippe Pibarot, Patrick Mathieu, Sylvie Bourassa, Audrey-Anne Després, Arnaud Girard, Marlys L. Koschinsky, Paolo Poggio, Jakie Guertin, Patricia L. Mitchell, Michael B. Boffa, Christian Couture, Patrick Couture, Romain Capoulade, Sébastien Thériault, Clarisse Gotti, Nicolas Perrot
Publikováno v:
CJC Open, Vol 3, Iss 4, Pp 450-459 (2021)
CJC Open
CJC Open
Background: Lipoprotein(a) (Lp[a]), which consists of a low-density lipoprotein (LDL) bound to apolipoprotein(a), is one of the strongest genetic risk factors for atherosclerotic cardiovascular diseases. Few studies have performed hypothesis-free dir
Autor:
Leilei Liu, Lepeng Wang, Shuran Ma, Yike Sun, Qi Han, Ruisen Hao, Wenna Li, Guowen Du, Hairong Zhang, Pei Zhu
Publikováno v:
Journal of Traditional Chinese Medical Sciences, Vol 8, Iss 2, Pp 135-144 (2021)
Background: Based on the theory of “five Zang-organs corresponding to the seasons” in traditional Chinese medicine (TCM), physiological functions including emotions vary with the seasons. We aimed to investigate the seasonal photoperiod effects o
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 4, Pp 327-334 (2021)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6/Ube2l6) catalyzes protein ISGylation and ubiquitylation, post-translational modifications which regulate protein stability. Ube2l6 plays a role in promoting in vitro adipogenesis; however, its mechanis