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Publikováno v:
Journal of Infection and Public Health, Vol 14, Iss 8, Pp 1001-1009 (2021)
Journal of Infection and Public Health
Journal of Infection and Public Health
Introduction Preliminary studies showed that coronavirus disease 2019 (COVID-19) disrupts body immune system, including dysregulation of cytokine interleukin-6 (IL-6). IL-6 inhibitors agents have been used as treatment options for COVID-19, yet their
Autor:
Thad A. Rosenberger, Patrick S. Stumpf, Naguib Mechawar, Carl Ernst, Liam Crapper, Nahum Sonenberg, Luc Moquin, Liam Anuj O’Leary, Jelena Popic, Andreas Schuppert, Xin Zhang, Hyder A. Jinnah, Scott C. Bell, Huashan Peng, Ilse Gantois, Alain Gratton, Michel L. Tremblay, Lilit Antonyan, Hanrong Wu, Diane J. Sutcliffe, Nuwan C. Hettige, Malvin Jefri, Vincent McCarty, Ying Zhang, Ilaria Kolobova
Publikováno v:
Stem Cell Reports
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Stem cell reports 16(7), 1749-1762 (2021). doi:10.1016/j.stemcr.2021.06.003
Summary Mutations in HPRT1, a gene encoding a rate-limiting enzyme for purine salvage, cause Lesch-Nyhan disease which is characterized by self-injury and motor impairments. We leveraged stem cell and genetic engineering technologies to model the dis
Autor:
Jesudass Joseph Sahayarayan, Sukanya Panikar, Muthukrishnan Arun, Arunachalam Chinnathambi, Hak-Jae Kim, A. Usha Raja Nanthini, Sulaiman Ali Alharbi, G. Shoba, Omaima Nasif
Publikováno v:
Journal of Infection and Public Health, Vol 14, Iss 5, Pp 601-610 (2021)
Journal of Infection and Public Health
Journal of Infection and Public Health
Background The current health concern to the entire world is the chronic respiratory disease caused by coronavirus 2 (COVID-19). A specific treatment or proper therapy is still lacking, and the investigations from across the world for proper drug/vac
Autor:
Fatima K. Alshahrani, Mervat Mahrous, Medina A. Ahmed, Ghadah Almutiri, Fatehi Elzein, Eid Alsufyani, Ahmed Ibrahim, Meshal Altowairqi, Esam Murshid, Nouf Alnawshan, Mohammed Alsaeed, Turki Aldhehyan
Publikováno v:
Journal of Infection and Public Health, Vol 14, Iss 4, Pp 474-477 (2021)
Journal of Infection and Public Health
Journal of Infection and Public Health
Background Severe acute respiratory syndrome coronavirus 2 (SARS-cov-2), first described in December 2019, has now infected more than 28 million cases with almost one million deaths. Reinfection is not definitely established however disease recurrenc
Publikováno v:
International Journal of Infectious Diseases, Vol 105, Iss, Pp 245-251 (2021)
International Journal of Infectious Diseases
International Journal of Infectious Diseases
Objective: Elevated levels of pro-inflammatory cytokines are observed in severe COVID-19 infections, and cytokine storm is associated with disease severity. Tocilizumab, an interleukin-6 receptor antagonist, is used to treat chimeric antigen receptor
Autor:
Xiangping Tan, Li Liu, Qiao Zong, Hui Li, Heping Yang, Changjun Li, Nian Xiong, Jing Wang, Zuxun Lu, Yanhong Gong, Nan Jiang, Xiaoxv Yin
Publikováno v:
International Journal of Infectious Diseases, Vol 104, Iss, Pp 641-648 (2021)
International Journal of Infectious Diseases
International Journal of Infectious Diseases
Highlights • There is currently no specific antiviral therapy for patients with COVID-19. • Ribavirin and interferon-α were clinically used as repurposed antiviral drugs. • RBV/IFN-α therapy was not observed to any benefit in improving patien
Autor:
Tawanda Gumbo, Carleton M. Sherman, Devyani Deshpande, Shashikant Srivastava, Jan-Willem C. Alffenaar
Publikováno v:
International Journal of Infectious Diseases, Vol 104, Iss, Pp 680-684 (2021)
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Background Faropenem (F), an orally bioavailable β-lactam, kills Mycobacterium tuberculosis (Mtb) without the help of a β-lactamase inhibitor. This study explored the sterilizing effect of adding F once or twice daily to a linezolid (L) plus pyrazi
Publikováno v:
Journal of Advanced Research, Vol 28, Iss, Pp 51-62 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Introduction Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are commonly used surgical procedures for the repair of damaged periodontal tissues. These procedures include the use of a membrane as barrier to
Introduction Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are commonly used surgical procedures for the repair of damaged periodontal tissues. These procedures include the use of a membrane as barrier to
Publikováno v:
Journal of Advanced Research, Vol 27, Iss, Pp 55-69 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Sulfate-reducing bacteria are the main producer of hydrogen sulfide in the gut. • High concentrations of hydrogen sulfide are involved in gut inflammation. • Lactic acid bacteria can be sensitive to hydrogen
Highlights • Sulfate-reducing bacteria are the main producer of hydrogen sulfide in the gut. • High concentrations of hydrogen sulfide are involved in gut inflammation. • Lactic acid bacteria can be sensitive to hydrogen
Publikováno v:
Journal of Advanced Research, Vol 27, Iss, Pp 19-30 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Background Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play importan
Background Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes. Hydrogen sulfide (H2S), a novel gasotransmitter, is found to play importan