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of 133
pro vyhledávání: ''
Autor:
Arnaud Droit, Elvira Mass, Corey A. Scipione, Raphaëlle Bourgeois, Benoit J. Arsenault, Philippe Pibarot, Patrick Mathieu, Sylvie Bourassa, Audrey-Anne Després, Arnaud Girard, Marlys L. Koschinsky, Paolo Poggio, Jakie Guertin, Patricia L. Mitchell, Michael B. Boffa, Christian Couture, Patrick Couture, Romain Capoulade, Sébastien Thériault, Clarisse Gotti, Nicolas Perrot
Publikováno v:
CJC Open, Vol 3, Iss 4, Pp 450-459 (2021)
CJC Open
CJC Open
Background: Lipoprotein(a) (Lp[a]), which consists of a low-density lipoprotein (LDL) bound to apolipoprotein(a), is one of the strongest genetic risk factors for atherosclerotic cardiovascular diseases. Few studies have performed hypothesis-free dir
Autor:
Kimmo Porthan, Hannele Yki-Järvinen, Marju Orho-Melander, Panu K. Luukkonen, Sami Qadri, Anne K. Penttilä, Amalia Gastaldelli, Jussi Pihlajamäki, Henna Sammalkorpi, Anne Juuti, Ville Männistö, Melania Gaggini, Johanna Arola, A. Hakkarainen, Mika Ala-Korpela, Noora Ahlholm, Leanne Hodson, Tiina Lehtimäki
Funding Information: This study was supported by Academy of Finland Grant 309263 (H.Y.-J.) and Grant 138006 (J.P.), EU H2020 project ?Elucidating Pathways of Steatohepatitis? EPoS Grant 634413 (H.Y.-J.), H2020-JTI-IMI2 EU project 777377-2 Liver Inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b1234c3153825c13c260807f3846a9
https://aaltodoc.aalto.fi/handle/123456789/113033
https://aaltodoc.aalto.fi/handle/123456789/113033
Autor:
Anne Laure Rerole, Alain Carrié, Samir Saheb, David Masson, Wilfried Le Goff, Isabelle Fournel, Randa Bittar, Hélène Choubley, Thomas Gautier, Jean-Pierre Quenot, Jean-Paul Pais de Barros, Auguste Dargent, Laurent Lagrost
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1776-1783 (2020)
Journal of Lipid Research
Journal of Lipid Research, 2020, 61 (12), pp.1776-1783. ⟨10.1194/jlr.RA120001132⟩
J Lipid Res
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (12), pp.1776-1783. ⟨10.1194/jlr.RA120001132⟩
Journal of Lipid Research
Journal of Lipid Research, 2020, 61 (12), pp.1776-1783. ⟨10.1194/jlr.RA120001132⟩
J Lipid Res
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (12), pp.1776-1783. ⟨10.1194/jlr.RA120001132⟩
International audience; Lipopolysaccharide (LPS) is a key player for innate immunity activation. It is therefore a prime target for sepsis treatment, as antibiotics are not sufficient to improve outcome during septic shock. An extracorporeal removal
Autor:
Eveline Perret Hoigné, Nedelina Slavova, Andrea Felser, Andrea Lisa Steck, Mariana Atencio, Claudia Salvisberg, Alexander Laemmle, Fanny Mochel, André Schaller, Sandra Kurth, Matthias Gautschi, Jean-Marc Nuoffer
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 29, Iss, Pp 100814-(2021)
Laemmle, Alexander; Steck, Andrea Lisa; Schaller, André; Kurth, Sandra; Perret Hoigné, Eveline; Felser, Andrea Deborah; Slavova, Nedelina; Salvisberg, Claudia; Atencio, Mariana; Mochel, Fanny; Nuoffer, Jean-Marc; Gautschi, Matthias (2021). Triheptanoin-Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency. Molecular genetics and metabolism reports, 29, p. 100814. Elsevier 10.1016/j.ymgmr.2021.100814
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Elsevier, 2021, 29, pp.100814. ⟨10.1016/j.ymgmr.2021.100814⟩
Laemmle, Alexander; Steck, Andrea Lisa; Schaller, André; Kurth, Sandra; Perret Hoigné, Eveline; Felser, Andrea Deborah; Slavova, Nedelina; Salvisberg, Claudia; Atencio, Mariana; Mochel, Fanny; Nuoffer, Jean-Marc; Gautschi, Matthias (2021). Triheptanoin-Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency. Molecular genetics and metabolism reports, 29, p. 100814. Elsevier 10.1016/j.ymgmr.2021.100814
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Elsevier, 2021, 29, pp.100814. ⟨10.1016/j.ymgmr.2021.100814⟩
International audience; Mitochondrial malate dehydrogenase (MDH2) deficiency (MDH2D) is an ultra-rare disease with only three patients described in literature to date. MDH2D leads to an interruption of the tricarboxylic acid (TCA) cycle and malate-as
Autor:
Virginie Molle, Alexandre Stella, Nicolas Tomas, Mamadou Daffé, Odile Burlet-Schiltz, Marie Locard-Paulet, Hedia Marrakchi, Nguyen-Hung Le
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1180-1191 (2020)
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (8), pp.1180-1191. ⟨10.1194/jlr.RA120000747⟩
J Lipid Res
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (8), pp.1180-1191. ⟨10.1194/jlr.RA120000747⟩
J Lipid Res
Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique a
Autor:
Michael P. Czech
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 27-42 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 27-42 (2020)
Background: The diminished glucose lowering effect of insulin in obesity, called “insulin resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious maladies. Many publications on this topic have suggested numerous hy
Autor:
Elizabeth K. Fletcher, Athan Kuliopulos, Nga Nguyen, Srijoy Guha, Andrew Shearer, Daniel H. Cox, James D. Baleja, Ying Wang, Manal F. Abdelmalek, Lidija Covic, Rajashree Rana
Publikováno v:
Molecular Metabolism, Vol 29, Iss, Pp 99-113 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role in c
Autor:
Jelena Cvejić Hogervorst, Boris Milijašević, Ana Tomas, Aleksandar Rašković, Tatjana Ćebović, Veljko Ćućuz, Nebojša Stilinović, Ljilja Torović, Ljiljana Gojkovic-Bukarica
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 7, Pp 1036-1043 (2019)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Graphical abstract
Resveratrol was recognized as the major factor responsible for the beneficial properties of red wine. Several resveratrol-based dietary supplements are available, but their efficacy has not been sufficiently tested. This study
Resveratrol was recognized as the major factor responsible for the beneficial properties of red wine. Several resveratrol-based dietary supplements are available, but their efficacy has not been sufficiently tested. This study
Autor:
Teresita Bellido, Alexander G. Robling, April M. Hoggatt, Andrew J. Elmendorf, Daniel J. Horan, Amy Y. Sato, Fredrick M. Pavalko, Gabriela G. Loots, Whitney A. Bullock
Publikováno v:
iScience
iScience, Vol 20, Iss, Pp 205-215 (2019)
iScience, Vol 20, Iss, Pp 205-215 (2019)
Summary Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4K
Autor:
Richard C. Austin, Bruce E. Kemp, Stephanie A. Stypa, Gregory R. Steinberg, Brennan K. Smith, Bernardo L. Trigatti, Sonia Rehal, Emily A. Day, Geoff H. Werstuck, Rebecca J. Ford, Vanessa P. Houde, Morgan D. Fullerton, Šárka Lhoták
Publikováno v:
Molecular Metabolism, Vol 53, Iss, Pp 101321-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and cholest