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Autor:
Amit Meller, Maisa Nasser
Publikováno v:
iScience
iScience, Vol 25, Iss 1, Pp 103554-(2022)
iScience, Vol 25, Iss 1, Pp 103554-(2022)
Summary Single biomolecule sensing often requires the quantification of multiple fluorescent species. Here, we theoretically and experimentally use time-resolved fluorescence via Time Correlated Single Photon Counting (TCSPC) to accurately quantify f
Autor:
Ikram Ullah Khan, Yasser Shahzad, Maimoona Maqbool, Syed A. A. Rizvi, Khadija Majid, Jorabar Singh Nirwan, Yeteng He, Ambreen Aleem, Adnan Younus, Yasir Mehmood, Muhammad Usman Ghori, Abid Mehmood Yousaf, Talib Hussain, Muhammad Arshad
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 8, Pp 994-1003 (2020)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The
Autor:
Chelsey Bennett, Mcclure Megan J, Georgia D. Tomaras, Michael S. Seaman, Clark Rutilio H, Randal R. Ketchem, J. Alaina Floyd, Kelly E. Seaton, Christine C. Siska, Yan Brodsky, Jeremy M. Shaver, Bryan T. Mayer, Nicole L. Yates, Bruce A. Kerwin, Alison J. Gillespie
Publikováno v:
Journal of Pharmaceutical Sciences
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework
Autor:
Prem Kumar Govindappa, Ayyalasomayajula Ratna Phani, Jagadeesh S. Sanganal, Raghavendra Lakshmana Shetty Hallur, Darukeshwara Joladarashi
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 1, Pp 147-154 (2020)
Saudi Pharmaceutical Journal : SPJ
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Saudi Pharmaceutical Journal : SPJ
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2020-12-12T01:51:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 H2020 LEIT Nanotechnologies Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usag
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 1, Pp 25-32 (2020)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Chitosan derivatives are reported as anticoagulants in the literature. This work was undertaken to develop novel chitosan derivatives as anticoagulants. The sulfonated derivatives of chitosan were formed by the reaction of chitosan derivatives with c
Publikováno v:
International Journal of Biological Macromolecules
Vora, L K, Courtenay, A J, Tekko, I A, Larrañeta, E & Donnelly, R F 2020, ' Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules ', International Journal of Biological Macromolecules, vol. 146, pp. 290-298 . https://doi.org/10.1016/j.ijbiomac.2019.12.184
Vora, L K, Courtenay, A J, Tekko, I A, Larrañeta, E & Donnelly, R F 2020, ' Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules ', International Journal of Biological Macromolecules, vol. 146, pp. 290-298 . https://doi.org/10.1016/j.ijbiomac.2019.12.184
One specific technological advance in transdermal drug delivery is the development of dissolving microneedles (DMNs), which efficiently deliver therapeutics through a rapid dissolution of polymers after penetration into the skin. However, there is a
Autor:
Weixin Tao, Neil P. J. Price, Liyuan Kong, Xiaoqin Liu, Kun Shen, Tang Zenglin, Gudan Xu, Yu Zheng, You-Sheng Cai, Zixin Deng, Wenqing Chen, Jingwen Wang
Publikováno v:
iScience, Vol 22, Iss, Pp 430-440 (2019)
iScience
iScience
Summary Minimycin (MIN) is a C-nucleoside antibiotic structurally related to pseudouridine, and indigoidine is a naturally occurring blue pigment produced by diverse bacteria. Although MIN and indigoidine have been known for decades, the logic underl
Autor:
Suman Mallick, Xiaoli Chen, Yi Yang Wu, Gang Yi Wang, Junpeng Zhou, Yi Qin, Tao Cheng, Chun Y. Liu, Lijiu Cao, Miao Meng, Ying Ning Tan, Guang Yuan Zhu
Publikováno v:
iScience, Vol 22, Iss, Pp 269-287 (2019)
iScience
iScience
Summary Studies of intermolecular interactions enhance our knowledge of chemistry across molecular and supramolecular levels. Here, we show that host-guest quadrupolar interaction has a profound influence on the molecular system. With covalently bond
Publikováno v:
iScience, Vol 22, Iss, Pp 195-205 (2019)
iScience
iScience
Summary A versatile method for atroposelective synthesis of chiral biaryl diamines and amino alcohols has been developed via para-amination of anilines and phenols with azodicarboxylates enabled by chiral phosphoric acid catalysis. Meanwhile, highly
Autor:
Yu-chi Liu, Ying-Chen Lin, Satoshi Watanabe, Kentaro Katsuyama, Yuki Nakamura, Kenji Inaba, Kazue Kanehara
Publikováno v:
iScience, Vol 21, Iss, Pp 577-586 (2019)
iScience
iScience
Summary Arabidopsis FLOWERING LOCUS T (FT) is a pivotal component of florigen, a long-range mobile flowering signal. Here, we determined the 1.0 Å-resolution crystal structure of FT, a significantly higher-resolution crystal structure of FT than pre