Zobrazeno 1 - 10
of 302
pro vyhledávání: ''
Autor:
Weixin Tao, Neil P. J. Price, Liyuan Kong, Xiaoqin Liu, Kun Shen, Tang Zenglin, Gudan Xu, Yu Zheng, You-Sheng Cai, Zixin Deng, Wenqing Chen, Jingwen Wang
Publikováno v:
iScience, Vol 22, Iss, Pp 430-440 (2019)
iScience
iScience
Summary Minimycin (MIN) is a C-nucleoside antibiotic structurally related to pseudouridine, and indigoidine is a naturally occurring blue pigment produced by diverse bacteria. Although MIN and indigoidine have been known for decades, the logic underl
Autor:
Suman Mallick, Xiaoli Chen, Yi Yang Wu, Gang Yi Wang, Junpeng Zhou, Yi Qin, Tao Cheng, Chun Y. Liu, Lijiu Cao, Miao Meng, Ying Ning Tan, Guang Yuan Zhu
Publikováno v:
iScience, Vol 22, Iss, Pp 269-287 (2019)
iScience
iScience
Summary Studies of intermolecular interactions enhance our knowledge of chemistry across molecular and supramolecular levels. Here, we show that host-guest quadrupolar interaction has a profound influence on the molecular system. With covalently bond
Publikováno v:
iScience, Vol 22, Iss, Pp 195-205 (2019)
iScience
iScience
Summary A versatile method for atroposelective synthesis of chiral biaryl diamines and amino alcohols has been developed via para-amination of anilines and phenols with azodicarboxylates enabled by chiral phosphoric acid catalysis. Meanwhile, highly
Autor:
Yu-chi Liu, Ying-Chen Lin, Satoshi Watanabe, Kentaro Katsuyama, Yuki Nakamura, Kenji Inaba, Kazue Kanehara
Publikováno v:
iScience, Vol 21, Iss, Pp 577-586 (2019)
iScience
iScience
Summary Arabidopsis FLOWERING LOCUS T (FT) is a pivotal component of florigen, a long-range mobile flowering signal. Here, we determined the 1.0 Å-resolution crystal structure of FT, a significantly higher-resolution crystal structure of FT than pre
Publikováno v:
iScience, Vol 21, Iss, Pp 650-663 (2019)
Summary: Heterocycles are prevalent constituents of many marketing drugs and biologically active molecules to meet modern medical challenges. Isocyanide insertion into C(sp3)–H bonds is challenging especially for the construction of quaternary carb
Autor:
Wenhao Hu, Ciwang He, Xiaolu Zhang, Xinfang Xu, Chao Pei, Shanliang Dong, Cheng Zhang, Kemiao Hong
Publikováno v:
iScience, Vol 21, Iss, Pp 499-508 (2019)
iScience
iScience
Summary A gold-catalyzed 6-endo-dig carbocyclization of alkyne with the pendent diazo group is reported. It provides an expeditious approach for the synthesis of multi-functionalized naphthalene derivatives under mild conditions. Mechanistic studies
Publikováno v:
iScience, Vol 21, Iss, Pp 490-498 (2019)
Summary: The direct functionalization of C(sp3)-H bonds has led to the development of methods to access molecules or intermediates from basic chemicals in an atom- and step-economic fashion. Nevertheless, achieving high levels of chemo-, regio-, and
Autor:
Jan Lipfert, Vijay K. Tiwari, Abhijeet Pataskar, Willem Vanderlinden, Johannes Friedrich Emmerig, Aditi Singh
Publikováno v:
iScience, Vol 21, Iss, Pp 638-649 (2019)
iScience
Pataskar, A, Vanderlinden, W, Emmerig, J, Singh, A, Lipfert, J & Tiwari, V K 2019, ' Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features ', iScience, vol. 21, pp. 638-649 . https://doi.org/10.1016/j.isci.2019.10.055
iScience
Pataskar, A, Vanderlinden, W, Emmerig, J, Singh, A, Lipfert, J & Tiwari, V K 2019, ' Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features ', iScience, vol. 21, pp. 638-649 . https://doi.org/10.1016/j.isci.2019.10.055
Summary Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show t
Publikováno v:
iScience, Vol 20, Iss, Pp 229-236 (2019)
iScience
iScience
Summary A new strategy for the synthesis of conjugated (E,E)-dienones and (E,E)-dienals via a palladium-catalyzed aerobic γ,δ-dehydrogenation of enones and enals has been developed. The method can be employed in the direct and efficient synthesis o
Autor:
Shintaro Iwama, Ryoichi Banno, Bernhard Bettler, Akira Mizoguchi, Keigo Taki, Mariko Sugiyama, Motomitsu Goto, Hiroshi Arima, Taku Tsunekawa, Hidetaka Suga, Hiroshi Takagi, Hiroshi Yaginuma, Takeshi Onoue, Yoshihiro Ito, Daisuke Hagiwara
Publikováno v:
iScience, Vol 20, Iss, Pp 337-347 (2019)
Summary: Binge eating could contribute to the development of obesity, and previous studies suggest that gamma-aminobutyric acid (GABA) type B receptor (GABABR) signaling is involved in the regulation of binge eating. Here, we show that time-restricte