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of 5
pro vyhledávání: '"Mark S. Anderson"'
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Autor:
Elise M. N. Ferré, Michail S. Lionakis, Michael Snyder, Tove Fall, Gustav Smith, Eva Freyhult, Donald Sharon, Daniel Eriksson, Nils Landegren, Petter Brodin, Olle Kämpe, Lindsey B. Rosen, Mark S. Anderson
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, ‘private’ aut
Autor:
Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi
Publikováno v:
eLife, Vol 11 (2022)
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understo
Externí odkaz:
https://doaj.org/article/fc84c5436a6d424088e17402a161e72b
Autor:
Audrey M Hendley, Arjun A Rao, Laura Leonhardt, Sudipta Ashe, Jennifer A Smith, Simone Giacometti, Xianlu L Peng, Honglin Jiang, David I Berrios, Mathias Pawlak, Lucia Y Li, Jonghyun Lee, Eric A Collisson, Mark S Anderson, Gabriela K Fragiadakis, Jen Jen Yeh, Chun Jimmie Ye, Grace E Kim, Valerie M Weaver, Matthias Hebrok
Publikováno v:
eLife, Vol 10 (2021)
To study disease development, an inventory of an organ's cell types and understanding of physiologic function is paramount. Here, we performed single-cell RNA-sequencing to examine heterogeneity of murine pancreatic duct cells, pancreatobiliary cells
Externí odkaz:
https://doaj.org/article/62699ea62af1409c840ff2fb6ef43383
Autor:
Kristen L Wells, Corey N Miller, Andreas R Gschwind, Wu Wei, Jonah D Phipps, Mark S Anderson, Lars M Steinmetz
Publikováno v:
eLife, Vol 9 (2020)
Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific
Externí odkaz:
https://doaj.org/article/7e6e9a65e4af4c6ea418368160781fcd
Autor:
Sara E Vazquez, Elise MN Ferré, David W Scheel, Sara Sunshine, Brenda Miao, Caleigh Mandel-Brehm, Zoe Quandt, Alice Y Chan, Mickie Cheng, Michael German, Michail Lionakis, Joseph L DeRisi, Mark S Anderson
Publikováno v:
eLife, Vol 9 (2020)
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and
Externí odkaz:
https://doaj.org/article/1520599b04384010a0a8ecbeae8656f8