Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chris I. De Zeeuw"'
Autor:
Sebastián Loyola, Tycho M Hoogland, Hugo Hoedemaker, Vincenzo Romano, Mario Negrello, Chris I De Zeeuw
Publikováno v:
eLife, Vol 12 (2023)
The inferior olive provides the climbing fibers to Purkinje cells in the cerebellar cortex, where they elicit all-or-none complex spikes and control major forms of plasticity. Given their important role in both short-term and long-term coordination o
Externí odkaz:
https://doaj.org/article/fe408a7b3a35414d8395bc5dbc4167b9
Autor:
Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying Shen
Publikováno v:
eLife, Vol 12 (2023)
The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module has a critical role in a presynaptic form of long-term potentiati
Externí odkaz:
https://doaj.org/article/ac0da0bbab3d459799ea9333440949dd
Autor:
Friedrich Krohn, Manuele Novello, Ruben S van der Giessen, Chris I De Zeeuw, Johan JM Pel, Laurens WJ Bosman
Publikováno v:
eLife, Vol 12 (2023)
Respiration is a brain function on which our lives essentially depend. Control of respiration ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In addition, the respiratory control network of the brain has to or
Externí odkaz:
https://doaj.org/article/69ca0e721e3648549029b6cf78af961c
Publikováno v:
eLife, Vol 9 (2020)
High-end technical approaches help to untangle the substructure and projection patterns of the cerebellum.
Externí odkaz:
https://doaj.org/article/6c13a200503b4cf4a2c1337508f93d5e
Autor:
Andres de Groot, Bastijn JG van den Boom, Romano M van Genderen, Joris Coppens, John van Veldhuijzen, Joop Bos, Hugo Hoedemaker, Mario Negrello, Ingo Willuhn, Chris I De Zeeuw, Tycho M Hoogland
Publikováno v:
eLife, Vol 9 (2020)
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor neural signals during unrestrained behavior and their open-source versions have made them affordable. Often, the footprint and weight of open-source miniscopes is sa
Externí odkaz:
https://doaj.org/article/276ffb5d3f42450e93f85febd7147aae
Autor:
Bin Wu, François GC Blot, Aaron Benson Wong, Catarina Osório, Youri Adolfs, R Jeroen Pasterkamp, Jana Hartmann, Esther BE Becker, Henk-Jan Boele, Chris I De Zeeuw, Martijn Schonewille
Publikováno v:
eLife, Vol 8 (2019)
Despite the canonical homogeneous character of its organization, the cerebellum plays differential computational roles in distinct sensorimotor behaviors. Previously, we showed that Purkinje cell (PC) activity differs between zebrin-negative (Z–) a
Externí odkaz:
https://doaj.org/article/a9026aa4734a4afca2461feffd8a1e97
Autor:
Vincenzo Romano, Licia De Propris, Laurens WJ Bosman, Pascal Warnaar, Michiel M ten Brinke, Sander Lindeman, Chiheng Ju, Arthiha Velauthapillai, Jochen K Spanke, Emily Middendorp Guerra, Tycho M Hoogland, Mario Negrello, Egidio D'Angelo, Chris I De Zeeuw
Publikováno v:
eLife, Vol 7 (2018)
Cerebellar plasticity underlies motor learning. However, how the cerebellum operates to enable learned changes in motor output is largely unknown. We developed a sensory-driven adaptation protocol for reflexive whisker protraction and recorded Purkin
Externí odkaz:
https://doaj.org/article/02283eaec87d4a6a87a0f4dae31b98cb
Autor:
Michiel M ten Brinke, Shane A Heiney, Xiaolu Wang, Martina Proietti-Onori, Henk-Jan Boele, Jacob Bakermans, Javier F Medina, Zhenyu Gao, Chris I De Zeeuw
Publikováno v:
eLife, Vol 6 (2017)
While research on the cerebellar cortex is crystallizing our understanding of its function in learning behavior, many questions surrounding its downstream targets remain. Here, we evaluate the dynamics of cerebellar interpositus nucleus (IpN) neurons
Externí odkaz:
https://doaj.org/article/da247d9c4eb44e758d76ab74e72e4cc2
Autor:
Ariel Zylberberg, Jeannette AM Lorteije, Brian G Ouellette, Chris I De Zeeuw, Mariano Sigman, Pieter Roelfsema
Publikováno v:
eLife, Vol 6 (2017)
The study of decision-making has mainly focused on isolated decisions where choices are associated with motor actions. However, problem-solving often involves considering a hierarchy of sub-decisions. In a recent study (Lorteije et al. 2015), we repo
Externí odkaz:
https://doaj.org/article/75297e69e78747e585fbd7449b30af98
Autor:
Haibo Zhou, Zhanmin Lin, Kai Voges, Chiheng Ju, Zhenyu Gao, Laurens WJ Bosman, Tom JH Ruigrok, Freek E Hoebeek, Chris I De Zeeuw, Martijn Schonewille
Publikováno v:
eLife, Vol 3 (2014)
Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological characteristics have traditionally been considered to be homogeneous. In this study, we show in awake mice at rest that spiking activity of Purkinje cells, the s
Externí odkaz:
https://doaj.org/article/6b008b28da6f4a1194cabf8146a808c4