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Autor:
Rodolfo Ocádiz Delgado, Lourdes Alarcón, María Luisa Roldán, Rene Asomoza, Perla Yaceli Uc, Patricio Gariglio, Liora Shoshani, Enoc Mariano Cortés‑Malagón, G. Ramirez, Lorenza González‑Mariscal, Bibiana Chávez‑Munguía, Jael Miranda, Arturo Raya‑Sandino
Publikováno v:
International Journal of Oncology
Tight junctions (TJs) are cell‑cell adhesion structures frequently altered by oncogenic transformation. In the present study the role of human papillomavirus (HPV) 16 E7 oncoprotein on the sealing of TJs was investigated and also the expression lev
Publikováno v:
Molecular Medicine Reports
The present study aimed to investigate whether the cytoskeleton, the Piezo1 ion channel and the transient receptor potential cation channel subfamily V member 4 (TRPV4) ion channel are equally functional in the mechanotransduction of periodontal liga
Publikováno v:
Molecular Medicine Reports
Periodontal ligament stem cells (PDLSCs) are vital for the regeneration of periodontal tissue. Transforming growth factor (TGF) β1, a potent stimulator of tissue regeneration, is extensive and abundant in the bone matrix. However, the effect of TGF
Publikováno v:
Oncology Reports
Bone marrow‑derived mesenchymal stem cells (MSCs), are the basic cellular components that make up the bone marrow microenvironment (BMM). In acute myeloid leukemia (AML), the morphology and function of MSCs changes in accordance with the transforma
Autor:
Bin He, Hanxiang Zhang
Publikováno v:
Molecular Medicine Reports
Low back pain (LBP) is a ubiquitous disease affecting quality of life. The ingrowth of new blood vessels is an important pathological feature of LBP, but its underlying mechanisms are poorly understood. The present study aimed to investigate the infl
Autor:
Jiong Li, Yichen Yin, Jifeng Zhang, Xiaonan Zhu, Sumei Li, Fengming Wu, Guoqing Guo, Caihui Cha
Publikováno v:
Molecular Medicine Reports
Amyloid β (Aβ) has been reported to have an important role in the cognitive deficits of Alzheimer's disease (AD), as oligomeric Aβ promotes synaptic dysfunction and triggers neuronal death. Recent evidence has associated an endocytosis protein, en
MEK inhibition prevents TGF-β1-induced myofibroblast transdifferentiation in human tenon fibroblasts
Publikováno v:
Molecular Medicine Reports
Subconjunctival fibrosis represents the primary cause of postoperative failure of trabeculectomy, and at present there is a lack of effective intervention strategies. The present study aimed to investigate the effect of the mitogen‑activated protei
Publikováno v:
Molecular Medicine Reports
Dedifferentiated adipose cells (DAs) and adipose‑derived stem cells (ADSCs) are two of the primary types of stem cells derived from adipose tissue, which have been reported to possess similar characteristics, but also exhibit unique phenotypic and
Publikováno v:
Molecular Medicine Reports
Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific deme
Autor:
Masahiko Haneda, Shingo Hashimoto, Tomoyuki Matsumoto, Nobuaki Chinzei, Shinsuke Kihara, Kazuhiro Takeuchi, Shinya Hayashi, Kotaro Nishida, Ryosuke Kuroda, Koji Takayama
Publikováno v:
Molecular Medicine Reports
Inflammation serves an important role in the progression of osteoarthritis (OA), and IL‑1β may act as a catabolic factor on cartilage, reducing the synthesis of primary cartilage components type II collagen and aggrecan. Aquaporin 1 (AQP1) is a 28