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Autor:
Kukiko Sakihama, Shinjiro Nagao, Akiko Fujimura, Kazunori Nakayama, Shu Ichimiya, Hideya Onishi, Yasuhiro Oyama, Satoko Koga, Akira Imaizumi, Yoshinao Oda, Masafumi Nakamura
Publikováno v:
Oncology Reports
We previously reported that Hedgehog (Hh) signal was enhanced in gallbladder cancer (GBC) and was involved in the induction of malignant phenotype of GBC. In recent years, therapeutics that target Hh signaling have focused on molecules downstream of
Publikováno v:
Oncology Reports
Long non‑coding RNA growth arrest specific 5 (GAS5) exerts inhibitory effects through the modulation of several target microRNAs (miRs) in cancer. However, its potential roles and underlying relationship during colorectal cancer (CRC) progression a
Publikováno v:
Molecular Medicine Reports
Osteoarthritis is a chronic degenerative joint disease. Long non‑coding RNA plasmacytoma variant translocation 1 (PVT1) is involved in the progression of osteoarthritis and exosomes serve a central role in intercellular communication. However, whet
Publikováno v:
Molecular Medicine Reports
Symptomatic degenerative disc disease (DDD) is considered the leading cause of chronic lower back pain (LBP). As one of the main features of intervertebral disc degeneration (IDD), vascular ingrowth plays a crucial role in the progression of LBP. Str
Autor:
Electra Nicolaidou, Kyriakos Xenos, Anna Tagka, Dimitris Rigopoulos, Maria Lagiou, Polytimi Sidiropoulou, Leda Kovatsi, Demetrios A. Spandidos, Maria Sifaki, Martha‑Spyridoula Katsarou, Nikolaos Drakoulis, Dimitra Ieronymaki, Christos Dagklis, Alexander E. Nosyrev, Stamatis Gregoriou, Styliani Mastraftsi
Publikováno v:
International Journal of Molecular Medicine
An association of vitamin D receptor (VDR) polymorphisms and vitiligo has been suggested. However, previous studies have reported contradictory results while including limited data among Caucasians. The aim of this single-center study was to evaluate
Upregulated microRNA-330-3p promotes calcification in the bicuspid aortic valve via targeting CREBBP
Autor:
Chen Su, Haoliang Sun, Buqing Ni, Jiaxi Gu, Junjie Du, Rui Zheng, Yaojun Guo, Yongfeng Shao, Hao Liu, Keshuai He
Publikováno v:
Molecular Medicine Reports
One key risk factor of aortic valve stenosis in clinical practice is bicuspid aortic valve (BAV). Increasing evidence indicates that numerous microRNAs (miRs/miRNAs) are involved in BAV calcification via their target genes. miR‑330‑3p was found t
Publikováno v:
Molecular Medicine Reports
MicroRNAs (miRNAs/miRs) are small noncoding RNAs 19‑24 nucleotides in length, which can play an important role in tumor development. However, the influence of miRNAs on the tumorigenicity of ovarian cancer cells has not been fully elucidated. Previ
Autor:
Rong Fu, Luogang Hua, Huaquan Wang, Zonghong Shao, Shanfeng Hao, Ning Xie, Yang Zhang, Na Xiao
Publikováno v:
Molecular Medicine Reports
Immuno-related pancytopenia (IRP) is characterized by pancytopenia resulting from bone marrow suppression or destruction mediated by auto‑antibodies. In our previous study, a K562 cDNA library was established, which was used to screen for seven pos
Autor:
Rui-Ming Liu, Junbing Lv, Baohong Jiang, He Rongzhou, Wen Li, Chong Lian, Jinsong Wang, Jiacong Qiu, Shenming Wang, Zhecun Wang
Publikováno v:
Molecular Medicine Reports
Increasing evidence suggests that T‑cell immunoglobulin and mucin domain 3 (TIM‑3) displays anti‑atherosclerotic effects, but its role in vascular smooth muscle cells (VSMCs) has not been reported. The present study aimed to investigate the fun
Publikováno v:
International Journal of Oncology
Spinal metastasis occurs in 50-75% of bone metastases caused by hepatocellular carcinoma (HCC), and HCC-derived spinal metastasis can lead to a less favorable prognosis. Recently, several studies have demonstrated that C-X3-C motif chemokine ligand 1