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Activin/SMAD signaling in human embryonic stem cells (hESCs) ensures NANOG expression and stem cell pluripotency. In the presence of Wnt ligand, the Activin/SMAD transcription network switches to cooperate with Wnt/β-catenin and induce mesendodermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b052283623883e10169fd83606ca5a94
https://europepmc.org/articles/PMC5769769/
https://europepmc.org/articles/PMC5769769/
Autor:
Haley O. Tucker, Samuel Beck, Kendra R. Cook, Melissa Popowski, Catherine Rhee, Jonghwan Kim, Bum Kyu Lee, Azeen Anjum
Despite their origin from the inner cell mass, embryonic stem (ES) cells undergo differentiation to the trophectoderm (TE) lineage by repression of the ES cell master regulator Oct4 or activation of the TE master regulator Caudal-type homeobox 2 (Cdx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cee2e30ea4babf9a4c0d6bb4a50d63
https://europepmc.org/articles/PMC4201284/
https://europepmc.org/articles/PMC4201284/
Autor:
David M. Ornitz, Fanxin Long
Much of the mammalian skeleton is composed of bones that originate from cartilage templates through endochondral ossification. Elucidating the mechanisms that control endochondral bone development is critical for understanding human skeletal diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43194f11881cb7a23b2fd384ce6e0731
https://europepmc.org/articles/PMC3579395/
https://europepmc.org/articles/PMC3579395/
Autor:
Jennifer Nichols, Austin Smith
Specific cells within the early mammalian embryo have the capacity to generate all somatic lineages plus the germline. This property of pluripotency is confined to the epiblast, a transient tissue that persists for only a few days. In vitro, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5518eb3fd4d716807c280c3112797db3
https://europepmc.org/articles/PMC3405859/
https://europepmc.org/articles/PMC3405859/
Autor:
Emilie Besnard, Jean-Marc Lemaitre, Franck Pellestor, John De Vos, Sylvain Lehmann, Laure Lapasset, Jean-Marie Ramirez, Ollivier Milhavet, Nafissa Aït-Hamou, Alexandre Prieur, Amélie Babled, Julia Leschik
Publikováno v:
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2011, 25 (21), pp.2248-2253. ⟨10.1101/gad.173922.111⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2011, 25 (21), pp.2248-2253. ⟨10.1101/gad.173922.111⟩
Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40a19bada65eb028e33e2156f48aae5
https://europepmc.org/articles/PMC3219229/
https://europepmc.org/articles/PMC3219229/
Autor:
Arul M. Chinnaiyan, Ramzey Abujarour, Jindan Yu, Bin Zhao, Ian Lian, Sheng Ding, Kun-Liang Guan, Joungmok Kim, Mason A. Israel, Jiagang Zhao, Hideki Okazawa, Lawrence S.B. Goldstein
Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. YAP is phosphorylated and inhibited by the Lats kinase, a key component of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39508919a275abd5432c2e90751cfbe
https://europepmc.org/articles/PMC2878649/
https://europepmc.org/articles/PMC2878649/
Autor:
Karine Lefort, Dennis R. Roop, Caterina Missero, G. Paolo Dotto, Maranke I. Koster, Dario Antonini, Anna Mandinova, Zhuo Zhang, Bach Cuc Nguyen, Giusy Della Gatta, Alice Tommasi di Vignano, Jan Kitajewski, Jian Wang, Vikram Devgan, Giovanna Chiorino
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45629adf142056acecc726a41fa8bcd0
https://europepmc.org/articles/PMC1472299/
https://europepmc.org/articles/PMC1472299/
In skin, multipotent stem cells generate the keratinocytes of the epidermis, sebaceous gland, and hair follicles. In this paper, we show that Tcf3 and Lef1 control these differentiation lineages. In contrast to Lef1, which requires Wnt signaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64b904763eb6f463ca87d02e6433dc2
https://europepmc.org/articles/PMC312726/
https://europepmc.org/articles/PMC312726/
Although most cells undergo growth arrest during hypoxia, endothelial cells and placental cytotrophoblasts proliferate in response to low O(2). We demonstrate that proliferation of embryonic multilineage hematopoietic progenitors is also regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efdddf488d39b6991bb8dd4e2d0fdf5
https://europepmc.org/articles/PMC317070/
https://europepmc.org/articles/PMC317070/
Autor:
Claus Nerlov, Thomas Graf
Little is known about the transcription factors that mediate lineage commitment of multipotent hematopoietic precursors. One candidate is the Ets family transcription factor PU.1, which is expressed in myeloid and B cells and is required for the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c929f52789718e2297bf06bf024a155a
https://europepmc.org/articles/PMC317050/
https://europepmc.org/articles/PMC317050/