Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenneth I. Aston"'
As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact off-spring. Age-associated change to DNA cytosine met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f41d84d2094a6a0f3b4514eea701622
https://doi.org/10.1101/2023.03.21.533698
https://doi.org/10.1101/2023.03.21.533698
Autor:
Ryan H Miller, Chad A Pollard, Kristin R Brogaard, Andrew C Olson, Larry I Lipshultz, Erica B Johnstone, Yetunde O Ibrahim, Jim M Hotaling, Enrique F Schisterman, Sunni L Mumford, Kenneth I Aston, Tim G Jenkins
BackgroundComplex diseases have multifactorial etiologies making clinically actionable diagnostic markers difficult to identify. Novel tools with higher diagnostic yield and utility in driving personalized care are needed.MethodsWe utilized Illumina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45572d334584b34046ae7810586ee376
https://doi.org/10.1101/2022.02.04.479170
https://doi.org/10.1101/2022.02.04.479170
Autor:
Xichen Nie, Sarah K. Munyoki, Meena Sukhwani, Nina Schmid, Annika Missel, Benjamin R. Emery, Donor Connect, Jan-Bernd Stukenborg, Artur Mayerhofer, Kyle E. Orwig, Kenneth I. Aston, James M. Hotaling, Bradley R. Cairns, Jingtao Guo
SUMMARYAging human males display reduced reproductive health, however testis aging is poorly understood at the molecular and genomic level. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both young and older men (>60 years ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62aa0dc889987460e4ef0da9e995d8e6
https://doi.org/10.1101/2021.10.19.464550
https://doi.org/10.1101/2021.10.19.464550
Autor:
P de Vries, E Schaafsma, L. E. L. M. Vissers, Simon Cockell, Mauro Santibanez-Koref, Christian Gilissen, Miguel J. Xavier, Sabine Kliesch, Harsh Sheth, G S Holt, Frank Tüttelmann, Gdn Astuti, Jonathan Coxhead, Moira K O'Bryan, GW van der Heijden, Corinna Friedrich, Helen Turner, Brendan J Houston, Kathrin Fleischer, Antoni Riera-Escamilla, Joris A. Veltman, Kenneth I. Aston, Aneta Mikulasova, H Ismail, David J. Elliott, L. Ramos, Kevin McEleny, HE Smith, Liina Nagirnaja, Csilla Krausz, J Greenwood, Roos M. Smits, Francesco K. Mastrorosa, Bks Alobaidi, Claudia Gonzaga-Jauregui, LE Batty, Kwm D’Hauwers, D.D.M. Braat, Donald F. Conrad, Oud
IntroductionDe novo mutations (DNMs) are known to play a prominent role in sporadic disorders with reduced fitness1. We hypothesize that DNMs play an important role in male infertility and explain a significant fraction of the genetic causes of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25224d79980a7a76f4c1d8e08942fba
https://doi.org/10.1101/2021.02.27.433155
https://doi.org/10.1101/2021.02.27.433155
Autor:
Nina Neuhaus, Henrike Krenz, M. Murad Başar, Sabine Kliesch, Corinna Friedrich, Murat Cetinkaya, Roos M. Smits, Nadja Rotte, Frank Tüttelmann, Adrian Pilatz, Semra Kahraman, Joachim Wistuba, Burcu Turkgenc, Albrecht Röpke, Manon S. Oud, Susanne Ledig, Sehime Gulsun Temel, Alexandra M. Lopes, Donald F. Conrad, Daniela Fietz, Marius Wöste, Mahmut Cerkez Ergoren, Margot J. Wyrwoll, Martin Dugas, Joris A. Veltman, Kenneth I. Aston, Filipa Carvalho, João Gonçalves, Liina Nagirnaja, van der Heijden Gw
Male infertility affects ∼7% of men in Western societies, but its causes remain poorly understood. The most clinically severe form of male infertility is non-obstructive azoospermia (NOA), which is, in part, caused by an arrest at meiosis, but so f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94445d5e42914190742b05579134744e
Autor:
Jingtao Guo, Kenneth I. Aston, Thomas P. Huecksteadt, Emma R. James, James M. Hotaling, David Alonso, Patrick J. Murphy, Timothy G. Jenkins, D.T. Carrell, Brad R. Cairns, Hoidal, Dallin S. Broberg
SUMMARYPaternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. This study used mouse models to evaluate: 1) what impact paternal CS exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb399c5c072a8a86f55fa71e48ba2d94
https://doi.org/10.1101/750638
https://doi.org/10.1101/750638
BackgroundThe relationship between aging and epigenetic profiles has been highlighted in many recent studies. Models using somatic cell methylomes to predict age have been successfully constructed. However, gamete aging is quite distinct and as such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592125f88f82f078309605b872f4527e
https://doi.org/10.1101/220764
https://doi.org/10.1101/220764