Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joseph E. Powell"'
Autor:
Connor J Greatbatch, Qinyi Lu, Sandy Hung, Son N Tran, Kristof Wing, Helena Liang, Xikun Han, Tiger Zhou, Owen M Siggs, David A Mackey, Guei-Sheung Liu, Anthony L Cook, Joseph E Powell, Jamie E Craig, Stuart MacGregor, Alex W Hewitt
PURPOSEThe exact pathogenesis of primary open-angle glaucoma (POAG) is poorly understood. Genome-wide association studies (GWAS) have recently uncovered many loci associated with variation in intraocular pressure (IOP); a crucial risk factor for POAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e769cdbf07b1b5ad29b2e4c319047ee4
https://doi.org/10.1101/2023.02.01.526555
https://doi.org/10.1101/2023.02.01.526555
Autor:
Sophie Shen, Tessa Werner, Yuliangzi Sun, Woo Jun Shim, Samuel Lukowski, Stacey Andersen, Han Sheng Chiu, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Xiaoli Chen, Men Chee Tan, Joseph E. Powell, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant
SUMMARYThis study develops a versatile cell multiplexing and data analysis platform to gain knowledge gain into mechanisms of cell differentiation. We engineer a cell barcoding system in human cells enabling multiplexed single-cell RNA sequencing for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e44f1be4a7707f91b5d4bdb5a8b4c72
https://doi.org/10.1101/2022.10.12.511862
https://doi.org/10.1101/2022.10.12.511862
Using latent variables in gene expression data can help correct spurious correlations due to unobserved confounders and increase statistical power for expression Quantitative Trait Loci (eQTL) detection. Probabilistic Estimation of Expression Residua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f436247fc27b849bbbb3137bd6058692
https://doi.org/10.1101/2022.08.02.502566
https://doi.org/10.1101/2022.08.02.502566
Autor:
Jovana Maksimovic, Shivanthan Shanthikumar, George Howitt, Peter F Hickey, William Ho, Casey Anttila, Daniel V. Brown, Anne Senabouth, Dominik Kaczorowski, Daniela Amann-Zalcenstein, Joseph E. Powell, Sarath C. Ranganathan, Alicia Oshlack, Melanie R. Neeland
Inflammation is a key driver of cystic fibrosis (CF) lung disease, not addressed by current standard care. Improved understanding of the mechanisms leading to aberrant inflammation may assist the development of effective anti-inflammatory therapy. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f11c7b079d7017d40420dfcb7d8b57
https://doi.org/10.1101/2022.06.17.496207
https://doi.org/10.1101/2022.06.17.496207
Autor:
David L.H. Bennett, Sam O. Kleeman, Akira Wiberg, Georgios Baskozos, Joseph E. Powell, Benjamin Patel, Waheed-Ul-Rahman Ahmed, Michael Ng, Drew Neavin, Annina B. Schmid, Dominic Furniss
Trigger finger (TF) and carpal tunnel syndrome (CTS) are two common non-traumatic hand disorders that frequently co-occur. By identifying TF and CTS cases in UK Biobank (UKB), we confirmed a highly significant phenotypic association between the disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9d47e6ed6efe61b66a44f202e76506
https://doi.org/10.1101/2021.10.07.21264697
https://doi.org/10.1101/2021.10.07.21264697
Autor:
Ramon Massoni-Badosa, Joseph E. Powell, Maria Salvany, Catia Moutinho, Carlota Rubio-Perez, Vanessa T. Chin, Joan Seoane, Eduard Batlle, Dominik C. Kaczorowski, Ester Planas-Rigol, Marc Elosua-Bayes, Chia-Ling Chan, Paula Nieto, Domenica Marchese, Josep M. Piulats, Ana Henriques, Ivo Gut, Richard Gallagher, Holger Heyn, Juan L. Trincado, Patricia Lorden, Juan C. Nieto, Elisabetta Mereu, Sara Ruiz, Angela Chou, Sergio Aguilar-Fernández
Publikováno v:
Genome Research
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Res
Dipòsit Digital de la UB
Universidad de Barcelona
Genome Res
The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis and treatment response lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c8407d0e6650bb7bd44e14fc1d9cc0
http://hdl.handle.net/2445/180737
http://hdl.handle.net/2445/180737
Autor:
Drew Neavin, Alice Pébay, Catia Moutinho, Grace E. Lidgerwood, Angela Steinmann, Han Sheng Chiu, Uyen Nguyen, Mubarika Tyebally, Chia-Ling Chan, Nathan J. Palpant, Vikkitharan Gnanasambandapillai, Joseph E. Powell, Maciej S. Daniszewski, Damián Hernández, Chuan E. Lam, Alex W. Hewitt
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and under different conditions. Human induced pluripotent stem cells (hiPSCs) are uniquel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6e58c38f9c833db450f3c710189e85
https://doi.org/10.1101/2021.08.19.457030
https://doi.org/10.1101/2021.08.19.457030
Autor:
Walter Muskovic, Joseph E. Powell
Advances in droplet-based single cell RNA-sequencing (scRNA-seq) have dramatically increased throughput, allowing tens of thousands of cells to be routinely sequenced in a single experiment. In addition to cells, droplets capture cell-free “ambient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0c978051ec4de998c35280af337d03
https://doi.org/10.1101/2021.08.02.454717
https://doi.org/10.1101/2021.08.02.454717
Autor:
Craig Jee, Gnanasambandapillai, Stuart MacGregor, David A. Mackey, Damián Hernández, Xikun Han, Alex W. Hewitt, Uyen Nguyen, Joseph E. Powell, Lisa S. Kearns, Helena Liang, Nona Farbehi, Shiang Y. Lim, Clarke Je, Chia-Ling Chan, Grace E. Lidgerwood, Alice Pébay, Stuart L. Graham, Lerna Gulluyan, Maciej S. Daniszewski, Louise A. Rooney, Anne Senabouth, Emmanuelle Souzeau, Jarmon G Lees, Linda Clarke, Priyadharshini Sivakumaran, Rachael A. McCloy
To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd62af0be4c082bac473a4af4b066ba5
https://doi.org/10.1101/2021.07.14.452417
https://doi.org/10.1101/2021.07.14.452417
Autor:
Melissa H. Little, Joseph E. Powell, José Alquicira-Hernandez, Aude Dorison, Jessica M. Vanslambrouck, Sara E. Howden, Sean B. Wilson
Kidney organoids provide a valuable resource to understand kidney development and disease. Clustering algorithms and marker genes fail to accurately and robustly classify cellular identity between human pluripotent stem cell (hPSC)-derived organoid d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e606735a335d8d112696ddc5f605945b
https://doi.org/10.1101/2021.01.20.427346
https://doi.org/10.1101/2021.01.20.427346