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pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jorge Cruz-Reyes, Joshua Meehan, Karissa Hughes, Pawan K. Doharey, Shelly Gulati, Vikas Kumar, Mary Grace Martinez, Blaine H. M. Mooers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
Uridylate insertion/deletion RNA editing inTrypanosoma bruceiis a complex system that is not found in humans, so there is interest in targeting this system for drug development. This system uses hundreds of small non-coding guide RNAs (gRNAs) to modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86526f60b24f7c8ab3a3e12703e89126
https://doi.org/10.1101/524702
https://doi.org/10.1101/524702
Autor:
Richard P. Metz, Bhaskara R. Madina, Blaine H. M. Mooers, Jorge Cruz-Reyes, Ralf Bundschuh, Vikas Kumar
Publikováno v:
RNA. 20:1142-1152
Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms.
Autor:
James A. Wohlschlegel, Gokulan Kuppan, Sing-Hoi Sze, Yu-He Liang, Xinhua Ji, Bhaskara R. Madina, Laurie K. Read, Kurtis M. Downey, Ajay A. Vashisht, James C. Sacchettini, Jorge Cruz-Reyes
Publikováno v:
RNA. 17:1821-1830
The mitochondrial genome of kinetoplastids, including species of Trypanosoma and Leishmania, is an unprecedented DNA structure of catenated maxicircles and minicircles. Maxicircles represent the typical mitochondrial genome encoding components of the
Publikováno v:
RNA. 12:1292-1303
RBP16 is an abundant RNA binding protein from Trypanosoma brucei mitochondria that affects both RNA editing and stability. We report here experiments aimed at elucidating the mechanism of RBP16 function in RNA editing. In in vitro RNA editing assays,
Autor:
Alevtina G. Zhelonkina, Julie A. Law, Jorge Cruz-Reyes, Barbara Sollner-Webb, Catherine E. Huang, Vadim S. Alatortsev, Sean F. O'Hearn
Publikováno v:
RNA. 12:476-487
Trypanosome RNA editing is massive post-transcriptional U-insertion and U-deletion, which generates mature mRNA coding regions through cycles of endonuclease, terminal U transferase (TUTase) or 3′-U-exo, and ligase action. Both types of editing are