Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jiri Bartek"'
Autor:
Kristijan Ramadan, Andrew J. Wicks, Yilun Sun, Andrew Tutt, Eleanor Knight, Christopher J. Lord, Mercedes Pardo Calvo, Dragomir B. Krastev, Jyoti S. Choudhary, Yves Pommier, Shudong Li, Tanaji T. Talele, Jiri Bartek, Lu Yu, Stephen J. Pettitt, Daniel Weekes, Luned M. Badder, Rebecca Marlow
Summary paragraphPoly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1. How cells process trapped PARP1 remains unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40976d3695cd0608b753e0e491a87e4a
https://doi.org/10.1101/2021.07.16.452473
https://doi.org/10.1101/2021.07.16.452473
Autor:
Jiri Bartek, Alba Corman, Jordi Carreras-Puigvert, Maria Häggblad, Vanesa Lafarga, Dimitris C. Kanellis, Oscar Fernandez-Capetillo
mRNA translation is one of the most energy-demanding processes for living cells, alterations of which have been frequently documented in human disease. Using recently developed technologies that enable image-based quantitation of overall translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b9349637f537cf1750671bbf0a204c
Autor:
Jiri Lukas, Alexander Georgakilas, Nicholas E. Geacintov, Ioannis S. Pateras, Zvi Livneh, Nickolaos N. Giakoumakis, Luca Scorrano, Jiri Bartek, Athanassios Kotsinas, Zoi Lygerou, Umakanta Swain, Claudia Lukas, George Pappas, Panagiotis Galanos, Christina Glytsou, Vassilis L. Souliotis, Vassilis G. Gorgoulis, Ioanna Svolaki, Alexander Polyzos, Claus Storgaard Sørensen
BackgroundGenomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential to design appropriate therapeutic strategies. In a recent study we reported an unexpected oncogenic property of p21WAF1/Cip1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2184be41b4ccf88727f950fb0df0f354
https://doi.org/10.1101/195263
https://doi.org/10.1101/195263
Autor:
Konstantinos Vougas, Magdalena Krochmal, Thomas Jackson, Alexander Polyzos, Archimides Aggelopoulos, Ioannis S. Pateras, Michael Liontos, Anastasia Varvarigou, Elizabeth O. Johnson, Vassilis Georgoulias, Antonia Vlahou, Paul Townsend, Dimitris Thanos, Jiri Bartek, Vassilis G. Gorgoulis
A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs for each individual patient. For complex diseases such as cancer, characterized by high inter-patient variance, the implementation of precision medicine ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da1459fb0ffdf2690b49acda033e026
Autor:
Martin Mistrik, Jiri Bartek, MyungHee Lee, Jiri Lukas, Kenji Watanabe, Iva Protivankova, Masayuki Yamada, Eva Vesela, Hisao Masai, Niels Mailand
Publikováno v:
Genes & Development. 27:2459-2472
Cdc7 kinase regulates DNA replication. However, its role in DNA repair and recombination is poorly understood. Here we describe a pathway that stabilizes the human Cdc7–ASK (activator of S-phase kinase; also called Dbf4), its regulation, and its fu