Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ansuman T. Satpathy"'
Autor:
Tian-Tian Liu, Feiya Ou, Julia A. Belk, Prachi Bagadia, David A. Anderson, Vivek Durai, Winnie Yao, Ansuman T. Satpathy, Theresa L. Murphy, Kenneth M. Murphy
Publikováno v:
Genes & Development. 37:291-302
Individual elements within a superenhancer can act in a cooperative or temporal manner, but the underlying mechanisms remain obscure. We recently identified anIrf8superenhancer, within which different elements act at distinct stages of type 1 classic
Autor:
Christopher S. McGinnis, Zhuang Miao, Nathan E. Reticker-Flynn, Juliane Winker, Ansuman T. Satpathy
Publikováno v:
bioRxiv
SUMMARYTumor metastasis requires systemic remodeling of distant organ microenvironments which impacts immune cell phenotypes, population structure, and intercellular communication networks. However, our understanding of immune phenotypic dynamics in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dba8410e77c0b51b557b865d7cc60e
https://europepmc.org/articles/PMC10187284/
https://europepmc.org/articles/PMC10187284/
Autor:
Connor A. Tsuchida, Nadav Brandes, Raymund Bueno, Marena Trinidad, Thomas Mazumder, Bingfei Yu, Byungjin Hwang, Christopher Chang, Jamin Liu, Yang Sun, Caitlin R. Hopkins, Kevin R. Parker, Yanyan Qi, Ansuman T. Satpathy, Edward A. Stadtmauer, Jamie H.D. Cate, Justin Eyquem, Joseph A. Fraietta, Carl H. June, Howard Y. Chang, Chun Jimmie Ye, Jennifer A. Doudna
Publikováno v:
bioRxiv
SummaryCRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced chromosome loss is a universal phenomenon and evaluate its clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baf40bba37165f6e745af572aee8d6a
https://doi.org/10.1101/2023.03.22.533709
https://doi.org/10.1101/2023.03.22.533709
Autor:
Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh, Kopal Garg, Pauline Kautz, Lena Nitsch, Samantha D. Praktiknjo, Patrick Maschmeyer, Jeffrey M. Verboon, Jacob C. Gutierrez, Yajie Yin, Evgenij Fiskin, Wendy Luo, Eleni Mimitou, Christoph Muus, Rhea Malhotra, Sumit Parikh, Mark D. Fleming, Lena Oevermann, Johannes Schulte, Cornelia Eckert, Anshul Kundaje, Peter Smibert, Ansuman T. Satpathy, Aviv Regev, Vijay G. Sankaran, Suneet Agarwal, Leif S. Ludwig
Cells experience intrinsic and extrinsic pressures that affect their proclivity to expand and persistin vivo. In congenital disorders caused by loss-of-function mutations in mitochondrial DNA (mtDNA), metabolic vulnerabilities may result in cell-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a302a84cd1a039a55e3622f979122067
https://doi.org/10.1101/2022.11.20.517242
https://doi.org/10.1101/2022.11.20.517242
Autor:
Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Bence Daniel, Katalin Sandor, Dorota Klysz, Vandon T. Duong, Kylie Burdsall, Peng Xu, Meena Malipatlolla, Micah G. Donovan, Evan W. Weber, Robbie G. Majzner, Howard Y. Chang, Joaquin M. Espinosa, Ansuman T. Satpathy, Crystal L. Mackall
Adoptive T cell immune therapies mediate impressive clinical benefit in a fraction of patients, but anti-tumor effects are often limited by inadequate T cell potency. To identify genes limiting T cell effector function, we conducted genome-wide CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c4cb769a4ea3af40b5569af5a8250f
https://doi.org/10.1101/2022.09.02.506235
https://doi.org/10.1101/2022.09.02.506235
Autor:
Caleb A. Lareau, Yajie Yin, Katie Maurer, Katalin D. Sandor, Garima Yagnik, José Peña, Jeremy Chase Crawford, Anne M. Spanjaart, Jacob C. Gutierrez, Nicholas J. Haradhvala, Tsion Abay, Robert R. Stickels, Jeffrey M. Verboon, Vincent Liu, Jackson Southard, Ren Song, Wenjing Li, Aastha Shrestha, Laxmi Parida, Gad Getz, Marcela V. Maus, Shuqiang Li, Alison Moore, Rafael G. Amado, Aimee C. Talleur, Paul G. Thomas, Houman Dehghani, Thomas Pertel, Anshul Kundaje, Stephen Gottschalk, Theodore L. Roth, Marie J. Kersten, Catherine J. Wu, Robbie G. Majzner, Ansuman T. Satpathy
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are still being understood. For example, we currently lack a comprehensive underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec63a8c53880de2b646ab8bd497a0e0
https://doi.org/10.1101/2022.08.12.503683
https://doi.org/10.1101/2022.08.12.503683
Autor:
Arjun S Nanda, Ke Wu, Sivakanthan Kasinathan, Megan S Ostrowski, Andrew S Clugston, Ansuman T Satpathy, E Alejandro Sweet-Cordero, Hani Goodarzi, Vijay Ramani
We present SMRT-Tag: a multiplexable, PCR-free approach for constructing low-input, single-molecule Pacific Biosciences (PacBio) sequencing libraries through Tn5 transposition. As proof-of-concept, we apply SMRT-Tag to resolve human genetic and epige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff0743c4cb8cc2444d42075515bddeac
https://doi.org/10.1101/2022.08.07.502893
https://doi.org/10.1101/2022.08.07.502893
Autor:
Frank A. Buquicchio, Raissa Fonseca, Julia A. Belk, Maximilien Evrard, Andreas Obers, Yanyan Qi, Bence Daniel, Kathryn E. Yost, Ansuman T. Satpathy, Laura K. Mackay
SummaryMemory T cells provide rapid and long-term protection against infection and tumors. The memory CD8+ T cell repertoire contains phenotypically and transcriptionally heterogeneous subsets with specialized functions and recirculation patterns. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4f980bddd32ece8a1042125bb16850
https://doi.org/10.1101/2022.05.04.490680
https://doi.org/10.1101/2022.05.04.490680
Autor:
Julia A. Belk, Winnie Yao, Nghi Ly, Katherine A. Freitas, Yan-Ting Chen, Quanming Shi, Alfredo M. Valencia, Eric Shifrut, Nupura Kale, Kathryn E. Yost, Connor V. Duffy, Madeline A. Hwee, Zhuang Miao, Alan Ashworth, Crystal L. Mackall, Alexander Marson, Julia Carnevale, Santosh A. Vardhana, Ansuman T. Satpathy
T cell exhaustion limits anti-tumor immunity, but the molecular determinants of this process remain poorly understood. Using a chronic antigen stimulation assay, we performed genome-wide CRISPR/Cas9 screens to systematically discover genetic regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43c061aa8589a9656067aa9ec535a2a
https://doi.org/10.1101/2022.04.20.488974
https://doi.org/10.1101/2022.04.20.488974
Autor:
Bence Daniel, Kathryn E. Yost, Katalin Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez, Stefanie L. Meier, Julia A. Belk, Josephine R. Giles, E. John Wherry, Howard Y. Chang, Takeshi Egawa, Ansuman T. Satpathy
SUMMARYT cells activated by chronic antigen exposure in the setting of viral infections or cancer can adopt an exhausted T cell (Tex) state, characterized by reduced effector function and proliferative capacity, and the upregulation of inhibitory rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79b6659d88541b1c922c0c66cebbfe62
https://doi.org/10.1101/2021.12.16.472900
https://doi.org/10.1101/2021.12.16.472900