Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L. Hicks, Jacqueline A. Brosnan-Cashman, Tracy Jones, Carolina Gomes-Alexandre, Levent Trabzonlu, Alan K. Meeker, Angelo M. De Marzo, Christopher M. Heaphy
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef1a1ba0a18aa40f37adf6313ce02f2
https://doi.org/10.1101/2023.04.04.535575
https://doi.org/10.1101/2023.04.04.535575
Autor:
Jiayu Chen, Qizhi Zheng, Jessica L. Hicks, Levent Trabzonlu, Busra Ozbek, Tracy Jones, Ajay Vaghasia, Tatianna C. Larman, Rulin Wang, Mark C. Markowski, Sam R. Denmeade, Kenneth J. Pienta, Ralph H. Hruban, Emmanuel S. Antonarakis, Anuj Gupta, Chi V Dang, Srinivasan Yegnasubramanian, Angelo M. De Marzo
Publikováno v:
bioRxiv
Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal which can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9152ef8b48b925a2fa10a76d03f63ffc
https://doi.org/10.1101/2023.02.20.529259
https://doi.org/10.1101/2023.02.20.529259
Autor:
Harshath Gupta, Hitoshi Inoue, Yasutomo Nakai, Masashi Nakayama, Tracy Jones, Jessica Hicks, Balasubramanian Kumar, Meltem Gurel, William G. Nelson, Angelo M. De Marzo, Srinivasan Yegnasubramanian
Glutathione S-transferase pi 1 (GSTP1) is lowly expressed in normal prostate luminal cells and becomes induced in most proliferative inflammatory atrophy lesions (PIA). GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87711d1880913b395a6a9cf6865606a8
https://doi.org/10.1101/2022.12.21.521517
https://doi.org/10.1101/2022.12.21.521517
BackgroundThe non-proliferating polyaneuploid cancer cell (PACC) state is associated with therapeutic resistance in cancer. A subset of cancer cells enters the PACC state by polyploidization and acts as cancer stem cells by undergoing depolyploidizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31bf8d3c467510a15fcaa1d76345e94
https://doi.org/10.1101/2022.09.19.22280051
https://doi.org/10.1101/2022.09.19.22280051
Autor:
Laura A Sena, Rajendra Kumar, David E Sanin, Elizabeth A Thompson, D Marc Rosen, Susan L Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L Hicks, Tracy Jones, Kiara A. Bowers, Jillian N Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W Nathaniel Brennen, Sushant K Kachhap, Emmanuel S Antonarakis, Angelo M De Marzo, John T Isaacs, Mark C Markowski, Samuel R Denmeade
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d82b47707259bc746b90babc396b6619
https://doi.org/10.1101/2022.04.26.22274275
https://doi.org/10.1101/2022.04.26.22274275
Autor:
Mindy K Graham, Roshan Chikarmane, Rulin Wang, Ajay Vaghasia, Anuj Gupta, Qizhi Zheng, Bulouere Wodu, Xin Pan, Nicole Castagna, Jianyong Liu, Jennifer Meyers, Alyza Skaist, Sarah Wheelan, Brian W Simons, Charles Bieberich, William G Nelson, Theodore L DeWeese, Angelo M De Marzo, Srinivasan Yegnasubramanian
Evaluating the complex interplay of cell types in the tissue microenvironment is critical to understanding the origin and progression of diseases in the prostate and potential opportunities for intervention. Mouse models are an essential tool to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34876472691a77e09aef3721dcd1329
https://doi.org/10.1101/2022.01.31.478481
https://doi.org/10.1101/2022.01.31.478481
Autor:
Christopher M. Heaphy, Reza Zarinshenas, John R. Barber, Christine Davis, Jacqueline A. Brosnan-Cashman, Angelo M. De Marzo, Corinne E. Joshu, Elizabeth A. Platz, Alan K. Meeker
Telomeres, the repetitive DNA elements at chromosome ends, are pivotal for maintenance of genome integrity. Previous studies from our group and others have highlighted the translational potential of tissue-based telomere length measurements to addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6adce51f51c62fdd61c19b0017d3e44
https://doi.org/10.1101/2022.01.20.22269597
https://doi.org/10.1101/2022.01.20.22269597
Autor:
Angelo M. De Marzo, Radhika A. Patel, Gunes Guner, Harrison Tsai, Minh-Tam Pham, Ruedi Aebersold, Tiannan Guo, Akshay Bhamidipati, David M. Esopi, Jessica Hicks, Ajay Vaghasia, Michael C. Haffner, Nicolas Wyhs, Jin-Yih Low, Nicole Castagna, Srinivasan Yegnasubramanian, William G. Nelson
BACKGROUNDResistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new pre-clinical models that allow the investigation of resistance mechanisms and the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16685d7af4fcbe84d72fcf445bd5999a
https://doi.org/10.1101/2021.07.04.450352
https://doi.org/10.1101/2021.07.04.450352
Autor:
Janet Mendonca, Naiju Thomas, Sushant Kachhap, Kavya Boyapati, Liang Dong, Samuel R. Denmeade, Marc Rosen, Emmanuel S. Antonarakis, Carolina Gomes, Drew M. Pardoll, Max Coffey, Kenneth J. Pienta, Angelo M. De Marzo, Rajendra Kumar, Tracy Jones, Sadie Wiens, W. Nathaniel Brennen, Busra Ozbek, Suthicha Kanacharoen, Olutosin Owoyemi, Michael A. Carducci, David Z. Qian, John T. Isaacs, Deven Topiwala, Mark C. Markowski
The discovery that androgens play an important role in the progression of prostate cancer (PCa) has led to the development of androgen deprivation therapy as a first line of treatment against PCa. However, paradoxical growth inhibition has been obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5d3c7ce3b838c64f6be4e16c550bd6
https://doi.org/10.1101/2020.09.10.286252
https://doi.org/10.1101/2020.09.10.286252
Autor:
Michael C. Haffner, Busra Ozbek, Jonathan Coulter, Luke Mummert, Sarah E. Ernst, Christopher M. Heaphy, Karen S. Sfanos, Alan K. Meeker, William Guzman, Eva Shrestha, Janielle P. Maynard, Angelo M. De Marzo
Prostate adenocarcinoma is the second most commonly diagnosed cancer in men worldwide and the initiating factors are unknown. Oncogenic TMPRSS2:ERG (ERG+) gene fusions are facilitated by DNA breaks and occur in up to 50% of prostate cancers1,2. Infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef6a04190f2753f96d8b9c2151c1c5b
https://doi.org/10.1101/2020.07.27.224154
https://doi.org/10.1101/2020.07.27.224154