Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Samuel Flashner, Masataka Shimonosono, Norihiro Matsuura, Shinya Ohashi, Andres J. Klein-Szanto, J. Alan Diehl, Che-Hong Chen, Daria Mochly-Rosen, Hiroshi Nakagawa
The alcohol metabolite acetaldehyde is a potent human carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulates and causes genotoxic stress in cells expressing the dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ad695e0f6cee8a6a618115f7082b25
https://doi.org/10.1101/2023.04.03.534985
https://doi.org/10.1101/2023.04.03.534985
Autor:
Yan Zhou, Kathy Q. Cai, Yinfei Tan, Karthik Devarajan, Allison N. Lau, Tiffany Luong, Harvey Hensley, Tatiana Pazina, Suraj Peri, Andres J. Klein-Szanto, Matthew G. Vander Heiden, Jessica Wagner, Diana Restifo, Huamin Wang, Edna Cukierman, Neelima Shah, Warren D. Kruger, Ruchi Malik, Débora Barbosa Vendramini-Costa, Dustin Rollins, Igor Astsaturov, Kerry S. Campbell, Wafik S. El-Deiry, Janusz Franco-Barraza, Linara Gabitova, Roshan J. Thapa, Ralph Francescone, Sapna Gupta, Alexander Muir, Siddharth Balachandran
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multi-plex data from patient tissue, three-dimensional co-culturing in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348fba5889a8254a78fbf4ecc5b36c4c
https://doi.org/10.1101/330209
https://doi.org/10.1101/330209
Autor:
Priya Aggarwal, Douglas I. Lin, Craig H. Bassing, Mariusz A. Wasik, Andrew B. Gladden, Matthew D. Lessie, Laura L. Pontano, Beth Nuskey, J. Alan Diehl, Andres J. Klein-Szanto, Ami Goradia, Anil K. Rustgi
Publikováno v:
Genes & Development. 21:2908-2922
Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to
Autor:
Claudia D. Andl, Anil K. Rustgi, Andres J. Klein-Szanto, Douglas B. Stairs, Jiri Kalabis, Hiroshi Nakagawa, Cameron N. Johnstone, Wafik S. El-Deiry, Takaomi Okawa, Edna Cukierman, Carmen Z. Michaylira, Meenhard Herlyn
Publikováno v:
Genes & Development. 21:2788-2803
Esophageal cancer is a prototypic squamous cell cancer that carries a poor prognosis, primarily due to presentation at advanced stages. We used human esophageal epithelial cells as a platform to recapitulate esophageal squamous cell cancer, thereby p