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Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer
Autor:
Diana Restifo, Alena Klochkova, Neelima Shah, Ido Sloma, Rachel Chiaverelli, Linara Gabitova, Suraj Peri, Richard A. Moffitt, Emmanuelle Nicolas, Alexandra Mazitova, Kathy Q. Cai, Tiffiney R. Hartman, Edna Cukierman, Erica A. Golemis, Alana M. O’Reilly, Elizabeth Handorf, Igor Astsaturov, Janusz Franco-Barraza, Ralph Francescone
SummaryOncogenic transformation alters the metabolism of cellular nutrients to sustain tumor growth. We here define a mechanism by which modifications in cholesterol metabolism control the formation of pancreatic ductal adenocarcinoma (PDAC). Disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501275a1cbf2e88f727507f1a817bde7
https://doi.org/10.1101/633719
https://doi.org/10.1101/633719