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Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Autor:
Rodrigo de Oliveira Formiga, Flávia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antônia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Márick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clémence Martin, Pierre-Régis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, André Báfica, Véronique Witko-Sarsat, Fernando Spiller
Publikováno v:
bioRxiv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e80654188358ad8cc60996af3801d8
https://europepmc.org/articles/PMC9641843/
https://europepmc.org/articles/PMC9641843/
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
BackgroundWe present a multidisciplinary approach to clinical trial design and analysis in a pilot study (NCT02415621) in which evolution-based mathematical models guide patient-specific dosing for Abiraterone treatment in men with castrate resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4621cad95b12b3eeb3e571b112f8283
https://doi.org/10.1101/2021.11.30.21267059
https://doi.org/10.1101/2021.11.30.21267059
Autor:
Huang Li, ye guangqiang, zhou qiongqiong, feng chunying, xue mengdi, Zhang ZhaoXia, zhang kunli, li changyao, liu hongyang, Weng Chang-jiang, liu xiaohong
Host nucleic acid receptors can recognize the viral DNA or RNA upon virus infection, which further triggers multiple signal pathways to promote the translocation of the interferon regulatory factor 3 (IRF3) into nucleus and produce type I interferon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a1a897a129de9d3ffbd349cf0d8881
https://doi.org/10.1101/2021.12.01.470696
https://doi.org/10.1101/2021.12.01.470696
Autor:
Joel H. Vazquez, Stephanie D. Byrum, Hartmut Jaeschke, D. Keith Williams, Samuel G. Mackintosh, Mitchell R. McGill, William E. Lee, Stefanie Kennon-McGill, Jonathan A. Dranoff
Better biomarkers to predict death early in acute liver failure (ALF) are needed. To that end, we obtained early (study day 1) and later (day 3) serum samples from transplant-free survivors (n=28) and non-survivors (n=30) of acetaminophen (APAP)-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d993657aa0b3ce5df856233553bcd156
https://doi.org/10.1101/2021.11.30.21266453
https://doi.org/10.1101/2021.11.30.21266453
Autor:
Constance Kleijwegt, Armelle Corpet, Pascale Texier, Florent Bressac, Thomas Simonet, C. Cohen, Laurent Schaeffer, Patrick Lomonte
Promyelocytic Leukemia Nuclear Bodies (PML NBs) are nuclear membrane-less organelles physically associated with chromatin underscoring their crucial role in genome function. The H3.3 histone chaperone complex HIRA accumulates in PML NBs upon senescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5c548014c0fdfd56084f791ff466e1
https://doi.org/10.1101/2021.11.30.470516
https://doi.org/10.1101/2021.11.30.470516
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, resulting in most patients succumbing rapidly after diagnosis. With limited treatment options available, repurposing of current pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f8e637282145e804eb409e2ba34f64
https://doi.org/10.1101/2021.12.01.470755
https://doi.org/10.1101/2021.12.01.470755
Autor:
Ekaterina S. Komarova, Andrey G Tereshchenkov, Petr V. Sergiev, Dmitrii I. Shiriaev, Ilya A. Osterman, Alexander G. Myasnikov, Andrey L. Konevega, Yury S. Polikanov, Evgeny Pichkur, Alexey A. Bogdanov, Alena Paleskava, Pavel Kasatsky, Olga A. Dontsova
Publikováno v:
RNA
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a deriv
Autor:
Christian Burri, Babatunde Akano, Christian Lengeler, Elizabeth Omoluabi, Jean Okitawutshu, Nina C. Brunner, Gloria Tumukunde, Phyllis Awor, Ocheche Yusuf, Joseph Kimera, Manuel W Hetzel, Jean-Claude Kalenga, Kazeem Ayodeji, Irene Angiro, Charles Okon, James Okuma, Antoinette Tshefu, Tristan T. Lee, Theodoor Visser, Aita Signorell, Proscovia Athieno, Harriet G. Napier, Nadja Cereghetti, Valentina Buj, Giulia Delvento, Mark Lambiris
BackgroundAppropriate clinical management of severe malaria is critical to avert morbidity and death. Recommended treatment consists of an injectable antimalarial followed by a full course of oral artemisinin-based combination therapy (ACT). Children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5048001edcb16fb53a41dd1b85bec9da
https://doi.org/10.1101/2021.11.26.21266917
https://doi.org/10.1101/2021.11.26.21266917
Autor:
Nicholas E. Vangos, Hyuk-Soo Seo, Takashi Mizutani, Tinghu Zhang, Kenneth C. Anderson, Nathanael S. Gray, Teru Hideshima, Sirano Dhe-Paganon
Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide (Pom) bind to cereblon (CRBN) and trigger proteasomal degradation of neo-substrates IKZF1/3 leading to multiple myeloma (MM) cell apoptosis. Pomalidomide (Pom) also binds albe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e9e895d6bc8df555305968acf8003f
https://doi.org/10.1101/2021.11.30.469594
https://doi.org/10.1101/2021.11.30.469594