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Autor:
Jianhui Li, Mark Hochstrasser
Publikováno v:
J Cell Sci
The proteasome is central to proteolysis by the ubiquitin-proteasome system under normal growth conditions but is itself degraded through macroautophagy under nutrient stress. A recently described AMPK (AMP-activated protein kinase)-regulated ESCRT (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75844f7158eedb7c32f2d1dd77fca3a7
https://doi.org/10.1101/2021.09.21.461272
https://doi.org/10.1101/2021.09.21.461272
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
Microbiology Spectrum
Microbiology Spectrum
The current pneumococcal capsular polysaccharide (PPS) conjugate vaccine (PCV13) is less effective againstStreptococcus pneumoniaeserotype 3 (ST3), which remains a major cause of pneumococcal disease and mortality. Therefore, dissecting structure-fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05afba7ad8b80adccaaede4e2ec71ab
https://doi.org/10.1101/2021.08.02.454853
https://doi.org/10.1101/2021.08.02.454853
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7017eb3c92fbd0db344ca89a69472b
https://doi.org/10.1101/2021.07.19.452535
https://doi.org/10.1101/2021.07.19.452535
Autor:
Boya Zhang, Anthony Berardi, Colin F. Greineder, Peter M. Tessier, Alec A. Desai, Henriette A. Remmer, Ghasidit Pornnoppadol
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0252558 (2021)
PLoS ONE, Vol 16, Iss 10, p e0252558 (2021)
The identification of antibody variable regions in the heavy (VH) and light (VL) chains from hybridomas is necessary for the production of recombinant, sequence-defined monoclonal antibodies (mAbs) and antibody derivatives. This process has received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42989848b04e351455ff2a9bd334f3
https://doi.org/10.1101/2021.05.19.444780
https://doi.org/10.1101/2021.05.19.444780
Autor:
Florencia Díaz-Viraqué, Sebastián Pita, Paula Faral-Tello, Fernando Alvarez-Valin, Gustavo Adolfo Vallejo, Luisa Berná, Gonzalo Greif, Carlos Robello, Rita de Cássia Moreira de Souza
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009719 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
We sequenced maxicircles from T. cruzi strains representative of the species evolutionary diversity by using long-read sequencing, which allowed us to uncollapse their repetitive regions, finding that their real lengths range from 35 to 50 kb. T. cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c23af5666f1f8155b196546ac00e16
https://doi.org/10.1101/2021.05.11.443566
https://doi.org/10.1101/2021.05.11.443566
Autor:
Roy Matkovic, Angélique Lasserre, Virginie Vauthier, Marina Morel, Michaël M. Martin, Florence Margottin-Goguet, Pauline Larrous
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009609 (2021)
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009609 (2021)
PLoS Pathogens, Vol 17, Iss 10 (2021)
Human Immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) succeed to evade host immune defenses by using their viral auxiliary proteins to antagonize host restriction factors. HIV-2/SIVsmm Vpx is known for degrading SAMHD1, a factor impeding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dade0848cc9fc6a151c267cfec120e09
https://doi.org/10.1101/2021.05.06.442913
https://doi.org/10.1101/2021.05.06.442913
Autor:
Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
mTORC1 is a kinase complex regulating cell growth, proliferation and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36120c04dfaa3fc5886b70680a712c
https://doi.org/10.1101/2021.04.28.441853
https://doi.org/10.1101/2021.04.28.441853
Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0251611 (2021)
PLoS ONE, Vol 16, Iss 9, p e0251611 (2021)
Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases. Though non-canonical functions of tau have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcaab5c453fc7bd29a3d0a121d56720
https://doi.org/10.1101/2021.04.30.442101
https://doi.org/10.1101/2021.04.30.442101
Autor:
Friedrich C. Simmel, Lukas Oesinghaus
Publikováno v:
Angewandte Chemie (International Ed. in English)
bioRxiv
bioRxiv
Spatiotemporal control of the activity of CRISPR‐associated (Cas) proteins is of considerable interest for basic research and therapeutics. Here, we show that conditional guide RNAs (gRNAs) for Cas12a can be transcribed in mammalian cells by RNA po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab1919979bfdb5566371d2eba09f49f
https://doi.org/10.1101/2021.04.16.440136
https://doi.org/10.1101/2021.04.16.440136
Publikováno v:
Estell, C, Davidson, L, Steketee, P C, Monier, A & West, S 2021, ' ZC3H4 restricts non-coding transcription in human cells ', eLIFE, vol. 10, 2021;10:e67305 . https://doi.org/10.7554/eLife.67305
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
SUMMARYThe human genome encodes thousands of non-coding RNAs. Many of these terminate early and are then rapidly degraded, but how their transcription is restricted is poorly understood. In a screen for protein-coding gene termination factors, we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c57a9a647ed1ac578f15e8e7e965131
https://doi.org/10.1101/2021.02.10.430684
https://doi.org/10.1101/2021.02.10.430684