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pro vyhledávání: '"35"'
Marburg virus is a member of filoviridae and spreads severe Marburg hemorrhagic illness in humans and animals. Nowadays, there is no vaccine available that can completely stop the replication of Marburg replication. Therefore, this study is designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f34869806673ad09371bd1614c9e41
https://doi.org/10.1101/2021.07.01.450693
https://doi.org/10.1101/2021.07.01.450693
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
Autor:
Yuhong Zuo, Kevin S. Franco, Cedric Cagliero, Yan Ning Zhou, Mikhail Kashlev, Zhe Sun, Thomas D. Schneider, Chen Y, Ding Jun Jin
1AbstractInE. coli, one RNA polymerase (RNAP) transcribes all RNA species, and different regulons are transcribed by employing different sigma (σ) factors. RNAP containingσ38(σS) activates genes responding to stress conditions such as stationary p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d879fdca6921be08d1c312f08f16370a
Autor:
Andrew Jeremijenko, Zaina Al Kanaani, Peter Coyle, Houssein H. Ayoub, Einas Al Kuwari, Mohamed H. Al-Thani, Abdullatif Al Khal, Mohamed Ghaith Al Kuwari, Hadi M. Yassine, Hamad Eid Al Romaihi, Hanan F. Abdul Rahim, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Anvar Hassan Kaleeckal, Shameem Younuskunju, Joel A. Malek, Yasmin A. Mohamoud, Adeel A. Butt, Roberto Bertollini, Ayeda A. Ahmed, Laith J. Abu-Raddad, Hiam Chemaitelly, Gheyath K. Nasrallah
BackgroundReinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. Risk and incidence rate of SARS-CoV-2 reinfection were assessed in a large cohort of antibody-positive pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1903ed0692ab3a3877c590f504b5f01e
https://doi.org/10.1101/2021.01.15.21249731
https://doi.org/10.1101/2021.01.15.21249731
Autor:
Jonathan J. Knowlton, Gwen M. Taylor, Herbert W. Virgin, Danica M. Sutherland, Craig B. Wilen, Terence S. Dermody, Pavithra Aravamudhan, Kelly Urbanek, Robert C. Orchard
Engagement of cell-surface receptors by viruses is a critical determinant of viral tropism and disease. The reovirus attachment protein, σ1, binds sialylated glycans and proteinaceous receptors to mediate infection, but the specific requirements on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf05c1678d2df22adfd03907d4323b4
https://doi.org/10.1101/2020.08.03.235572
https://doi.org/10.1101/2020.08.03.235572
Autor:
Helge Bruelheide, Florian Jansen, F. Petzold, David Eichenberg, K.J. Conze, A. Drews, B. Trockur, Angela Günther, Diana E. Bowler, K. Baumann, A. Bönsel, M. Seyring, Frank Suhling, Nick J. B. Isaac, T. Bittner, Aletta Bonn, C. Willigalla, T. Spengler
Recent studies suggest insect declines in parts of Europe; however, the generality of these trends across different taxa and regions remains unclear. Standardized data are not available to assess large-scale, long-term changes for most insect groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49e9c795379e9fc496702ae162deae41
https://doi.org/10.1101/2020.08.03.234104
https://doi.org/10.1101/2020.08.03.234104
Imputation has been routinely used to infer sequence variants in large genotyped populations based on reference populations of sequenced individuals. With increasing numbers of animals sequenced and the implementation of the 1000 Bull Genomes Project
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b91d4a90ec5e5d478be8378f4ec5062
Quantitative analysis of differential gene expression is of central importance in molecular life sciences. The Gene eXpression Profiling technology (GeXP) relies on multiplex RT-PCR and subsequent capillary electrophoretic separation of the amplifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b5381394e7e86e73ad4882c47dd534
To understand the regulation of tissue-specific gene expression, the GTEx Consortium generated RNA-seq expression data for more than thirty distinct human tissues. This data provides an opportunity for deriving shared and tissue-specific gene regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b648b9c31a26181dfc40d97a9d85df0c
Autor:
Nehal K. Bhatt, Takeo Kubota, David H. Ledbetter, Apiwat Mutirangura, Arthur L. Beaudet, Scott A. Martin, A. Craig Chinault, Bing Huang, Susan L. Christian, James S. Sutcliffe
Publikováno v:
Genome Research. 8:146-157
Prader–Willi syndrome and Angelman syndrome are associated with parent-of-origin-specific abnormalities of chromosome 15q11–q13, most frequently a deletion of an ∼4-Mb region. Because of genomic imprinting, paternal deficiency of this region le