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Autor:
Peiyong Jiang, Meng Ni, Y.M. Dennis Lo, Danny K L Wong, Diana S.C. Han, K.C. Allen Chan, Rossa W.K. Chiu, Rebecca W.Y. Chan, Kathy O. Lui, Linda T. Hiraki, Stefano Volpi
Publikováno v:
Genome Res
The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. Compared to wild-type cfDNA, cfDNA in DNASE1L3-deficient mice was signifi
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
Publikováno v:
RNA (New York, N.Y.), vol 26, iss 9
RNA
RNA
Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on canonical cap-snatching, which occurs at the very
Publikováno v:
RNA
RNA (New York, N.Y.), vol 25, iss 12
RNA (New York, N.Y.), vol 25, iss 12
Pre-mRNA splicing is regulated through multiple trans-acting splicing factors. These regulators interact with the pre-mRNA at intronic and exonic positions. Given that most exons are protein coding, the evolution of exons must be modulated by a combi
Autor:
Srikanth Ramaswamy, Tanguy Damart, Dimitri Rodarie, Yann Roussel, Michael W. Reimann, Daniel Keller, Henry Markram, Csaba Veraszto
Author summaryThe computational abilities of the brain arise from its organization principles at the cellular level. One of these principles is the neuronal type composition over different regions. Since computational functions of neurons are best de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9c8d70a169685f1c356867fae0b3f7
https://doi.org/10.1101/2021.11.24.469815
https://doi.org/10.1101/2021.11.24.469815
Autor:
Srikanth Ramaswamy, Dimitri Rodarie, Henry Markram, Yann Roussel, Daniel Keller, Michael W. Reimann, Marc-Oliver Gewaltig, Csaba Veraszto
The mouse brain contains a rich diversity of inhibitory neuron types that have been characterized by their patterns of gene expression. However, it is still unclear how these cell types are distributed across the mouse brain. We developed a computati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0550e5bffaa2e29e2af4d2237a99fe69
https://doi.org/10.1101/2021.11.20.469384
https://doi.org/10.1101/2021.11.20.469384
Autor:
Shih-Hsin Lu, Lei Xu, Yanan Yang, Xiying Yu, Wei Jiang, Lili Qiao, Guodong Deng, Hui Yuan, Xiaohong Yu
Somatic stem cells are essential for maintenance of cell proliferation-differentiation homeostasis in organs. Despite the importance, how the esophageal epithelium that executes its self-renewal and maintenance remains elusive. In this study, using 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812a88183657f4d182f869efbd4f19b1
https://doi.org/10.1101/2021.11.11.468184
https://doi.org/10.1101/2021.11.11.468184
Autor:
Pekka Lappalainen, Michelle Suzanne Longworth, Vani Narayanan, Afshin Khan, Jaakko I. Lehtimäki, Susana Lechuga, Andrei I. Ivanov, Daniel E. Conway, Florian Rieder, Alexander X. Cartagena-Rivera, Bert I. Crawford
The actomyosin cytoskeleton serves as a key regulator of the integrity and remodeling of epithelial barriers by controlling assembly and functions of intercellular junctions and cell-matrix adhesions. While biochemical mechanisms that regulate activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4d864c2306d6ccfa5cef1a259be646
https://doi.org/10.1101/2021.11.10.467974
https://doi.org/10.1101/2021.11.10.467974
Activating mutations of Ras genes are often observed in cancer. The protein products of the three Ras genes are almost identical. However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace1b447fcc03d0bd37594b473ad7232
https://doi.org/10.1101/2021.11.04.467300
https://doi.org/10.1101/2021.11.04.467300
In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cca8ccc96413d513f5da132da15e8e
https://doi.org/10.1101/2021.10.25.465667
https://doi.org/10.1101/2021.10.25.465667