Zobrazeno 1 - 10
of 46
pro vyhledávání: '"35"'
Autor:
Yuhong Zuo, Kevin S. Franco, Cedric Cagliero, Yan Ning Zhou, Mikhail Kashlev, Zhe Sun, Thomas D. Schneider, Chen Y, Ding Jun Jin
1AbstractInE. coli, one RNA polymerase (RNAP) transcribes all RNA species, and different regulons are transcribed by employing different sigma (σ) factors. RNAP containingσ38(σS) activates genes responding to stress conditions such as stationary p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d879fdca6921be08d1c312f08f16370a
Autor:
Jonathan J. Knowlton, Gwen M. Taylor, Herbert W. Virgin, Danica M. Sutherland, Craig B. Wilen, Terence S. Dermody, Pavithra Aravamudhan, Kelly Urbanek, Robert C. Orchard
Engagement of cell-surface receptors by viruses is a critical determinant of viral tropism and disease. The reovirus attachment protein, σ1, binds sialylated glycans and proteinaceous receptors to mediate infection, but the specific requirements on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf05c1678d2df22adfd03907d4323b4
https://doi.org/10.1101/2020.08.03.235572
https://doi.org/10.1101/2020.08.03.235572
Autor:
Andrew Wang, Ala Trusina, Minjun Son, Savaş Tay, Sara Saheb Kashaf, Thomas Holst-Hansen, Tino Frank, Michael Junkin
Publikováno v:
Science Advances, 8 (35)
Son, M, Frank, T, Holst-Hansen, T, Wang, A G, Junkin, M, Kashaf, S S, Trusina, A & Tay, S 2022, ' Spatiotemporal NF-kappa B dynamics encodes the position, amplitude, and duration of local immune inputs ', Science Advances, vol. 8, no. 35, 6240 . https://doi.org/10.1126/sciadv.abn6240
Son, M, Frank, T, Holst-Hansen, T, Wang, A G, Junkin, M, Kashaf, S S, Trusina, A & Tay, S 2022, ' Spatiotemporal NF-kappa B dynamics encodes the position, amplitude, and duration of local immune inputs ', Science Advances, vol. 8, no. 35, 6240 . https://doi.org/10.1126/sciadv.abn6240
Infected cells communicate through secreted signaling molecules like cytokines, which carry information about pathogens. How differences in cytokine secretion affect inflammatory signaling over space and how responding cells decode information from p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12cfd87b9731a2a6eed3396c5610c91
https://doi.org/10.1101/2021.11.30.470463
https://doi.org/10.1101/2021.11.30.470463
Publikováno v:
Cell Reports, 35 (4)
Multi-subunit SMC ATPases control chromosome superstructure apparently by catalyzing a DNA-loop-extrusion reaction. SMC proteins harbor an ABC-type ATPase "head" and a "hinge" dimerization domain connected by a coiled coil "arm." Two arms in a SMC di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d016fad9f37a1df321b674e998b20142
https://doi.org/10.1101/2021.01.21.427566
https://doi.org/10.1101/2021.01.21.427566
A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes
Autor:
Bin Liu, Wei Shi, Wei Zhou, Abigail Schammel, Baoyue Zhang, Yangbo Hu, Yi Jiang, Shaojia Huang
In bacteria, σ28is the flagella-specific sigma factor that controls the expression of flagella-related genes involving bacterial motility and chemotaxis. However, its transcriptional mechanism remains largely unclear. Here we report cryo-EM structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d5c8449932d38a624ddd6843feb013
Positive and negative modes of regulation typically constrain synaptic growth and function within narrow physiological ranges. However, it is unclear how synaptic strength is maintained when both pre- and post-synaptic compartments continue to grow b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ddb1c03d5c68a5050f0900b38b11c1
https://doi.org/10.1101/840470
https://doi.org/10.1101/840470
Publikováno v:
Statistical Science
Statistical Science, Institute of Mathematical Statistics (IMS), 2020, 35 (1), pp.129-144. ⟨10.1214/19-STS7561⟩
Statist. Sci. 35, no. 1 (2020), 129-144
Statistical Science, Institute of Mathematical Statistics (IMS), 2020, 35 (1), pp.129-144. ⟨10.1214/19-STS7561⟩
Statist. Sci. 35, no. 1 (2020), 129-144
Recent years have produced a large amount of work on inference about cancer evolution from mutations identified in cancer samples. Much of the modeling work has been based on classical models of population genetics, generalized to accommodate time-va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1482c0df1efd095dd59f323fc8de536c
Autor:
Rob Phillips, Tal Einav
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cellular behavior is ultimately governed by the genetic program encoded in the cell’s DNA and through the arsenal of molecular machines that actively transcribe its genes, yet we lack the ability to predict how an arbitrary DNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03374b8cc53adcfe0f185760673ff203
https://doi.org/10.1101/597989
https://doi.org/10.1101/597989
Autor:
Leonid Minakhin, Daria Esyunina, Mikako Shirouzu, Shun-ichi Sekine, Shigeyuki Yokoyama, Andrey Kulbachinskiy, Ryogo Akasaka, Shunsuke Tagami, Konstantin Severinov
Publikováno v:
Genes & Development. 28:521-531
Transcription of DNA to RNA is the first step of gene expression and is accomplished by DNA-dependent RNA polymerase (RNAP). The bacterial RNAP core enzyme is an ∼400-kDa protein complex with a crab claw-like shape consisting of five subunits, α2
Publikováno v:
Genes & Development. 15:491-506
The α subunit of E. coli RNAP plays an important role in the recognition of many promoters by binding to the A+T-rich UP element, a DNA sequence located upstream of the recognition elements for the ς subunit, the −35 and −10 hexamers. We examin