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Autor:
Charlotte Flory, Kitt Wing Ki Chan, Jade K. Forwood, Julien Lescar, Sai Wang, Min Jie Alvin Tan, Dahai Luo, Subhash G. Vasudevan
Publikováno v:
RNA. 28:177-193
The commitment to replicate the RNA genome of flaviviruses without a primer involves RNA-protein interactions that have been shown to include the recognition of the stem-loop A (SLA) in the 5' untranslated region (UTR) by the nonstructural protein NS
Publikováno v:
RNA
The conventional view regarding regulation of gene expression is based on transcription control. However, a growing number of recent studies has revealed the important additional impact of translational regulation. Eukaryotic translational machinery
Publikováno v:
RNA
Many antibiotics that bind to the ribosome inhibit translation by blocking the movement of tRNAs and mRNA or interfering with ribosome dynamics, which impairs the formation of essential translocation intermediates. Here we show how translocation inhi
Autor:
Rui Fu, Neelanjan Mukherjee, William E. Rainey, Amber Baldwin, Kathryn Walters, Kimberly Wellman, Juilee Rege, Kent Riemondy, Antje Hirsekorn
Publikováno v:
RNA
Angiotensin II (AngII) binds to the type I angiotensin receptor in the adrenal cortex to initiate a cascade of events leading to the production of aldosterone, a master regulator of blood pressure. Despite extensive characterization of the transcript
Autor:
Valery F. Thompson, Jacob C. Schwartz, Michelle A Lay, Nasiha S. Ahmed, Lucas M. Harrell, Daniel R. Wieland
Publikováno v:
RNA
Ewing sarcoma is driven by fusion proteins containing a low complexity (LC) domain that is intrinsically disordered and a powerful transcriptional regulator. The most common fusion protein found in Ewing sarcoma, EWS-FLI1, takes its LC domain from th
Autor:
Shcherbakov, Dimitri, Duscha, Stefan, Juskeviciene, Reda, Restelli, Lisa M., Frank, Stephan, Laczkó, Endre, Bottger, Erik C., Böttger, Erik C.
Publikováno v:
RNA, 27 (3)
RNA
RNA
We have recently reported on an experimental model of mitochondrial mistranslation conferred by amino acid exchange V338Y in mitochondrial ribosomal protein MrpS5. Here we used a combination of RNA-seq and metabolic profiling of homozygous transgenic
Autor:
Bongmin Bae, Ting Feng, Hannah N. Gruner, Grant S. Mastick, Wei Yan, Kevin So, Simon Pieraut, Daniel Oliver, Pedro Miura, Maebh Lynch
Publikováno v:
RNA. 26:1414-1430
The majority of mouse and human genes are subject to alternative cleavage and polyadenylation (APA), which most often leads to the expression of two or more alternative length 3′ untranslated region (3′-UTR) mRNA isoforms. In neural tissues, ther
Publikováno v:
RNA (New York, N.Y.), vol 26, iss 9
RNA
RNA
Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on canonical cap-snatching, which occurs at the very
Publikováno v:
RNA
Ribosomes were once considered static in their composition because of their essential role in protein synthesis and kingdom-wide conservation. The existence of tolerated mutations in select ribosomal proteins (RPs), such as in Diamond-Blackfan anemia
Publikováno v:
RNA
During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3′–5′ degradation by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5′–3′ degradation by the rapid tRNA decay (RTD) pathway. RTD is catalyz