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Publikováno v:
Genes Dev
The p53 tumor suppressor functions as a tetrameric transcription factor to regulate hundreds of genes—many in a tissue-specific manner. Missense mutations in cancers in the p53 DNA-binding and tetramerization domains cement the importance of these
Publikováno v:
Genes & Development. 34:1227-1238
Identifying miRNA target genes is difficult, and delineating which targets are the most biologically important is even more difficult. We devised a novel strategy to test the phenotypic impact of individual microRNA–target interactions by disruptin
Autor:
Xiaoli Liu, Justin P. Norton, Deshui Jia, Renato G. Martins, Emily Eastwood, Huajia Zhang, Paul Leger, Keith D. Eaton, Eli Grunblatt, Nan Wu, Yamini M. Ohol, Rhiana Thomas, David MacPherson, A. McGarry Houghton, Joseph B. Hiatt, Ali H. Ibrahim, Ryan Basom
Publikováno v:
Genes Dev
Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we develope
Autor:
Kaifang Pang, Eder Xhako, Larissa Nitschke, Jennifer L. Johnson, Vincenzo A. Gennarino, Ambika Tewari, Stephanie L. Coffin, Zhandong Liu, Huda Y. Zoghbi, Francisco A. Blanco
Publikováno v:
Genes Dev
Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene
Publikováno v:
Genes & development, vol 34, iss 15-16
Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive
Autor:
Akihiko Taguchi, Biliana Marcheva, Gene W. Yeo, Emily C. Wheeler, Patrick E. MacDonald, Chiaki Omura, Marsha V. Newman, Yumiko Kobayashi, Eugene Wyatt, Mark Perelis, Archana Shankar, Jocelyn E. Manning Fox, Elizabeth M. McNally, Hee Kyung Hong, Benjamin J. Weidemann, Haopeng Lin, Kathryn Moynihan Ramsey, Joseph Bass
Publikováno v:
Genes Dev
The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-
Autor:
Ryne C. Ramaker, Say-Tar Goh, Andrew A. Hardigan, Barbara J. Wold, Richard M. Myers, Sara J. Cooper, E. Christopher Partridge
Publikováno v:
Genome Res
DNA associated proteins (DAPs) classically regulate gene expression by binding to regulatory loci such as enhancers or promoters. As expanding catalogs of genome-wide DAP binding maps reveal thousands of loci that, unlike the majority of conventional
Autor:
Hyeseon Kang, Martin W. Hetzer, Jesse R. Dixon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran
Publikováno v:
Genes Dev
During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated during nuclear reformation in anaphase/telophase. Many aspects of the underlying principles that mediate transcriptional memory and reactivation in the dau
Autor:
Simon Labbé, Carlo Yague-Sanz, Maxime Duval, Marc Larochelle, Jude Beaudoin, Ronan Fernandez, Yann Vanrobaeys, Julien Berro, François Bachand, Pierre-Étienne Jacques
Publikováno v:
Genes Dev
Transcription by RNA polymerase II (RNAPII) is a dynamic process with frequent variations in the elongation rate. However, the physiological relevance of variations in RNAPII elongation kinetics has remained unclear. Here we show in yeast that a RNAP
Publikováno v:
Genes Dev
The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome inactivation in mammals. Xist produces a long noncoding (lnc)RNA that accumulates over the entire length of the chromosome from which it is transcribed, recruiting