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Autor:
Mark E. Parrish, Robb Krumlauf, Bony De Kumar, Laurence Florens, Joan W. Conaway, Ariel Paulson, Narendra Pratap Singh, Ying Zhang, Kausik Si
Publikováno v:
Genes Dev
Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of proteins is poorly understood. We used cross-spe
Autor:
Frank McCormick, Claire Lorenzo
Publikováno v:
Genes Dev
Genes & development, vol 34, iss 21-22
Genes & development, vol 34, iss 21-22
The roles of SPRED proteins in signaling, development, and cancer are becoming increasingly recognized. SPRED proteins comprise an N-terminal EVH-1 domain, a central c-Kit-binding domain, and C-terminal SROUTY domain. They negatively regulate signali
Autor:
Liang Tong, Keith Hamilton
Publikováno v:
Genes Dev
Most eukaryotic pre-mRNAs must undergo 3′-end cleavage and polyadenylation prior to their export from the nucleus. A large number of proteins in several complexes participate in this 3′-end processing, including cleavage and polyadenylation speci
Autor:
Mike Kareh, Agnel Sfeir, Eros Lazzerini-Denchi, Noa Lamm, Anthony J. Cesare, Alexandra M. Pinzaru
Publikováno v:
Genes Dev
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact
Autor:
Shimaa Soliman, Jeffrey N. Savas, Ali Shilatifard, Andrea Piunti, Marc A. Morgan, Ryan Rickels, Edwin R. Smith, Lu Wang, Emily J. Rendleman, Natalia Khalatyan, Marta Iwanaszko, Patrick A. Ozark
Publikováno v:
Genes Dev
Catalytic-inactivating mutations within the Drosophila enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene deletions for these COMPASS members. To identify
Autor:
Jerry L. Workman, Jelly H.M. Soffers
Publikováno v:
Genes Dev
There are many large protein complexes involved in transcription in a chromatin context. However, recent studies on the SAGA coactivator complex are generating new paradigms for how the components of these complexes function, both independently and i
Autor:
Minhong Shen, Hanqiu Zheng, Yibin Kang, Yi-Zhou Jiang, Zhi Ming Shao, Ruina Zhang, Yong Wei, Wenyang Li
Publikováno v:
Genes Dev
SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 6
Publikováno v:
Genes Dev
When converging replication forks meet during replication termination, the CMG (Cdc45–MCM2–7–GINS) helicase is polyubiquitylated by CRL2Lrr1 and unloaded from chromatin by the p97 ATPase. Here, we investigate the signal that triggers CMG unload
Autor:
Eric L. Van Nostrand, Jeanine L. Van Nostrand, En-Ching Luo, Kristina Hellberg, Jingting Yu, Yelena Dayn, Reuben J. Shaw, Alina Dayn, Gene W. Yeo, Maxim N. Shokhirev
Publikováno v:
Genes Dev
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic bene
Publikováno v:
Genes Dev
TRF1 facilitates the replication of telomeric DNA in part by recruiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand template. Lagging-strand telomeres lacking TRF1 or BLM form fragile telomeres—structures that resemble