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Publikováno v:
Genes Dev
p53 is an important tumor suppressor, and the complexities of p53 function in regulating cancer cell behaviour are well established. Many cancers lose or express mutant forms of p53, with evidence that the type of alteration affecting p53 may differe
Publikováno v:
Genes Dev
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but rather a distinct and heterogeneous population of glia with various functions in the developing and adult central nervous system. In this review, we discuss
Publikováno v:
Genes & Development. 34:239-249
Addressing the complexity of organogenesis at a system-wide level requires a complete understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary has been a model to study how coordinated stem cell units, germli
Autor:
David Bernard, Christelle Machon, Joanna Czarnecka-Herok, Charlotte Scholtes, Jérôme Guitton, Jennifer Rieusset, Mathieu Vernier, Vincent Giguère, Dorian V. Ziegler, Nadine Martin
Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated secretory phenotype. Accumulation of senescent cells during age-related diseases participates in these pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd55dfb430c96f120aef364f0f3482e6
https://doi.org/10.1101/2021.10.20.465100
https://doi.org/10.1101/2021.10.20.465100
Autor:
Stefan Pöhlmann, Samuel James Watson, Markus Hoffmann, Edward J. D. Greenwood, Thomas W M Crozier, Paul J. Lehner, Gavin J. Wright, Tekle Pauzaite, Christian M. Gawden-Bone, James A. Nathan, Brian Ortmann, Jarrod Shilts, Ildar Gabaev, Ana Teixeira-Silva
SummaryThe interactions between severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to COVID-19. The spike protein is the largest structural component of the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c745d2a09185fb2899e2caf0a429112f
https://doi.org/10.1101/2021.09.25.461776
https://doi.org/10.1101/2021.09.25.461776
Autor:
Ismini Kloukina, Elena Katsantoni, Ariana Gavriil, Ethan Ford, Maria Manioudaki, Anastasia Apostolidou, Paschalis Sideras, Olli Ritvos, Georgios Divolis, Maria Xilouri, Athanasios Stavropoulos, Georgios Germanidis, Alexandros Sountoulidis, Despina Perrea, Athanasia Doulou
Transforming Growth Factor-βs (TGFβs)/Activins and Bone Morphogenetic Proteins (BMPs) have been implicated in numerous aspects of hepatic pathophysiology. However, the way by which hepatocytes integrate and decode the interplay between the TGFβ/Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8aca3ec995229747b32d094a83d437
https://doi.org/10.1101/2021.07.23.453185
https://doi.org/10.1101/2021.07.23.453185
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed5c07f0b21ed9b02f6aea222d90ea7
https://doi.org/10.1101/2021.05.10.443436
https://doi.org/10.1101/2021.05.10.443436
Autor:
Maritza Puray-Chavez, Dhaval P. Bhatt, Steven L. Brody, James E. Crowe, D. Neil Hayes, Emily M. Cousins, Adam L. Bailey, Amjad Horani, Zhuoming Liu, Dennis Goldfarb, Sean P. J. Whelan, Nakyung Lee, M. Ben Major, Jenna E. Eschbach, Paul W. Rothlauf, Erica W. Cloer, Jennifer L Elliott, Kyle M. LaPak, Ria Jasuja, Pavlo Gilchuk, Hung R. Vuong, Christian Shema Mugisha, Heejoon Jo, Sebla B. Kutluay, Keanu Davis, Travis P. Schrank, Megan J. Agajanian, Kasyap Tenneti, Michael S. Diamond, Dana Q. Lawson, Laura A. VanBlargan
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports, Vol 36, Iss 2, Pp 109364-(2021)
Cell Reports
article-version (status) pre
article-version (number) 1
Cell Reports, Vol 36, Iss 2, Pp 109364-(2021)
Cell Reports
SARS-CoV-2 spike (S) variants govern transmissibility, responsiveness to vaccination and disease severity. In a screen for new models of SARS-CoV-2 infection, we identified human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ab279dc74bdfceae4b25f51be1a1c5
https://doi.org/10.1101/2021.03.01.433431
https://doi.org/10.1101/2021.03.01.433431
Autor:
Krishani Dinali Perera, Yunjeong Kim, Stanley Perlman, Lok-Yin Roy Wong, Kevin P. Battaile, Chamandi S Dampalla, William C. Groutas, Kyeong-Ok Chang, Scott Lovell, Jian Zheng, Maithri M. Kashipathy, Harry Nhat Nguyen, David K. Meyerholz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Protease inhibitors targeting viral 3C-like protease are attractive therapeutic options for COVID-19. Here, we synthesized deuterated variants of a coronavirus protease inhibitor, GC376, and determined the therapeutic efficacy in a letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e465e62866d5759c0bf1b322ee6498
https://doi.org/10.1101/2021.02.05.429937
https://doi.org/10.1101/2021.02.05.429937