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Autor:
Cody Ashby, Brian A Walker, Marco Trevisan-Herraz, Sharmilan Thanendrarajan, Kent Fung, Agata Cieslak, Shmuel Yaccoby, Maurizio Zangari, Aneta Mikulasova, Daniel Rico, Vahid Asnafi, Lisa J. Russell, Nefeli Karataraki, Anne E. Corcoran, Daniel Kent, Sophie Hambleton, Carolina Schinke, Gareth J. Morgan, Salvatore Spicuglia, Frits van Rhee, Chris A. Brackley
Publikováno v:
Mikulasova, A, Kent, D, Trevisan-Herraz, M, Karataraki, N, Fung, K T M, Ashby, C, Cieslak, A, Yaccoby, S, van Rhee, F, Zangari, M, Thanendrarajan, S, Schinke, C, Morgan, G J, Asnafi, V, Spicuglia, S, Brackley, C A, Corcoran, A E, Hambleton, S, Walker, B A, Rico, D & Russell, L J 2021, ' Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers ', Genome Research, vol. 2022, 32, pp. 1343-1354 . https://doi.org/10.1101/gr.276042.121
Chromosomal translocations are important drivers of haematological malignancies whereby proto-oncogenes are activated by juxtaposition with enhancers, often called enhancer hijacking. We analysed the epigenomic consequences of rearrangements between
Publikováno v:
Genes & Development. 35:1271-1289
PARP inhibitor (PARPi) is widely used to treat BRCA1/2-deficient tumors, but why PARPi is more effective than other DNA-damaging drugs is unclear. Here, we show that PARPi generates DNA double-strand breaks (DSBs) predominantly in a trans cell cycle
Autor:
Peter B. Becker, Aline Campos Sparr, Andreas W. Thomae, Tobias Straub, Janosch Hennig, Raffaella Villa, Ignasi Forné, Pravin Kumar Ankush Jagtap
Publikováno v:
Genes & Development. 35:1055-1070
The dosage compensation complex (DCC) ofDrosophilaidentifies its X-chromosomal binding sites with exquisite selectivity. The principles that assure this vital targeting are known from theD. melanogastermodel: DCC-intrinsic specificity of DNA binding,
Autor:
Rowan P. Herridge, Jonathan Cahn, Robert A. Martienssen, Daniel Grimanelli, Jean-Sébastien Parent
Publikováno v:
Genes Dev
Epigenetic reprogramming occurs during gametogenesis as well as during embryogenesis to reset the genome for early development. In flowering plants, many heterochromatic marks are maintained in sperm, but asymmetric DNA methylation is mostly lost. As
Autor:
Lily Zhu, Naseem Maghzian, Carla B. Green, Aarati Pokharel, Camille T. Schrier, Jacob C. Deslauriers, Kevin He, John J. Tyson, Nobuya Koike, Allison N. Castaneda, Shihoko Kojima, Joseph S. Takahashi, Rebecca A. Mosig, Landon P. Frazier
Publikováno v:
Genes & Development. 35:899-913
In mammals, a set of core clock genes form transcription–translation feedback loops to generate circadian oscillations. We and others recently identified a novel transcript at the Period2 (Per2) locus that is transcribed from the antisense strand o
Autor:
Jade Doughty, Yusheng Zhao, Caroline Dean, Jo Hepworth, Pan Zhu, Amelie Heckmann, Hongchun Yang, Rea L. Antoniou-Kourounioti, Congyao Xu, Rebecca H. Bloomer
Publikováno v:
Genes Dev
Plants monitor many aspects of their fluctuating environments to help align their development with seasons. Molecular understanding of how noisy temperature cues are registered has emerged from dissection of vernalization in Arabidopsis, which involv
Autor:
James Chuang, Magdalena Murawska, Dan Spatt, Dhawal Jain, Olga V. Viktorovskaya, Fred Winston, L. Stirling Churchman, Francheska Lopez-Rivera, Peter J. Park, Natalia I. Reim
Publikováno v:
Genes Dev
Histone chaperones are critical for controlling chromatin integrity during transcription, DNA replication, and DNA repair. Three conserved and essential chaperones, Spt6, Spn1/Iws1, and FACT, associate with elongating RNA polymerase II and interact w
Publikováno v:
Genes Dev
Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells
Publikováno v:
Genes Dev
Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and MDMX have rich lives outside of their relationship to p53. There is much to learn about how these two proteins are regulated and how they can function in cells tha
Publikováno v:
Genes Dev
During the development of the vertebrate nervous systems, genetic programs assemble an immature circuit that is subsequently refined by neuronal activity evoked by external stimuli. However, prior to sensory experience, the intrinsic property of the