Zobrazeno 1 - 10
of 14
pro vyhledávání: ''
Autor:
Cynthia R. Cherry, Glen J. Weiss, Ritu R. Gill, Anushi Bulumulle, Meghan Shea, Danielle C. McDonald, Kartik Sehgal, Paul A. VanderLaan, Daniel B. Costa, Shravanti Macherla, Deepa Rangachari, Heather Brody, Aleksandra Qilleri, Paul R. Walker, Mark S. Huberman
Publikováno v:
Clinical Lung Cancer
Background Besides modeling/simulation-based analysis, no post-approval studies have evaluated optimal administration frequency of pembrolizumab in non-small cell lung cancer (NSCLC). Patients and Methods We performed a multicenter retrospective coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1dd1543fdf73d34426b5b31ee77e97
https://doi.org/10.1101/2020.03.31.20048637
https://doi.org/10.1101/2020.03.31.20048637
Autor:
Ryan S. Jackson, Mackenzie Daly, Jason I. Kass, Tiantian Li, Evisa Gjini, Youstina Hanna, Ian S. Hagemann, Liye Zhou, Douglas Adkins, Trevor J. Pugh, Gavin P. Dunn, Jessica Ley, Wade L. Thorstad, Glenn J. Hanna, Scott J. Rodig, Rachel S. Riley, Randal C. Paniello, Malachi Griffith, David Mulder, Tianxiang Lin, Ana Lako, Nicholas C. Spies, Matthew D. Stachler, Jason T. Rich, Rebecca D. Chernock, Loren S. Michel, Ravindra Uppaluri, Dorina Kallogjeri, Patrik Pipkorn, Robert I. Haddad, Vickie Y. Jo, Brian Nussenbaum, Jonathan D. Schoenfeld, Iulia Cirlan, Jay F. Piccirillo, Peter Oppelt, Paul Zolkind, Ann Marie Egloff, Obi L. Griffith, Zachary L. Skidmore, Erica K. Barnell, Tenny Mudianto, Katie M. Campbell
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 19
Clin Cancer Res
Int J Radiat Oncol Biol Phys
Clin Cancer Res
Int J Radiat Oncol Biol Phys
SUMMARYBackgroundPembrolizumab improved survival of patients with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The aims of this phase 2 trial were to determine if pembrolizumab administered to patients with resectable locall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8902376009ddebcea905e680e2c23c75
https://doi.org/10.1101/2020.03.18.20037846
https://doi.org/10.1101/2020.03.18.20037846
Autor:
X Steven Chen, Michael R. Marco, Julio Garcia-Aguilar, J. Joshua Smith, R. Daniel Beauchamp, Bing Zhang, Bryan C. Szeglin, Hyun Sung Park, Zeda Zhang, Chao Wu
Publikováno v:
Cancer Reports, Vol 5, Iss 1, Pp n/a-n/a (2022)
Cancer Reports
Cancer Reports
Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in the United States and a leading cause of cancer‐related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82970e25bf78332c62bf7eb605ce1da
Autor:
Violetta Zujovic, Guillermo Estivill-Torrús, Laura Leyva, Anne Baron Van-Evercooren, Jerold Chun, Jennifer Fransson, Ana Isabel Gómez-Conde, Oscar Fernández, Beatriz Garcia-Diaz, Fernando Rodríguez de Fonseca, Celine Louapre, Jesús Romero-Imbroda
Publikováno v:
Molecular Neurobiology
Molecular Neurobiology, Humana Press, In press, ⟨10.1007/s12035-020-02130-x⟩
Molecular Neurobiology, Humana Press, In press, ⟨10.1007/s12035-020-02130-x⟩
Multiple sclerosis (MS) is a neuro-inflammatory disease for which the pathogenesis remains largely unclear. Lysophosphatidic acid (LPA) is an endogenous phospholipid that is involved in multiple immune cell functions and is dysregulated in MS. Its re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1286ed96106b5e1b2533443c623c55a
Autor:
Yvette Hooks, Monika Tripathi, Carl A. Anderson, Sigurgeir Olafsson, Tim Raine, Michael R. Stratton, Tim H. H. Coorens, Claire Dawson, Philip S. Robinson, Miles Parkes, Kenneth Arestang, Peter J. Campbell, Mathijs A. Sanders, Rebecca E. McIntyre, Konstantina Strongili, Inigo Martincorena, Hyunchul Jung, Henry Lee-Six, Tim Butler
Publikováno v:
Cell
Cell, 182(3), 672-684.e11. Cell Press
Cell, 182(3), 672-684.e11. Cell Press
Summary Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts from 41 non-IBD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d760bc4c98ffcfdf2b87e1c6a33ce6
https://doi.org/10.1101/832014
https://doi.org/10.1101/832014
Autor:
James Varani, Ananda Sen, Ingrid L. Bergin, Suzanna M. Zick, Muhammad Aslam, Karsten Knuver, Christine M. Bassis, D. Kim Turgeon
Publikováno v:
Cancer Prev Res (Phila)
Aquamin is a calcium-, magnesium-, and multiple trace element–rich natural product with colon polyp prevention efficacy based on preclinical studies. The goal of this study was to determine the effects of Aquamin on colonic microbial community and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ee483dbb9fc6334d93f3c49240c128
Autor:
Laura M. Raffield, Alex P. Reiner, Andrew D. Johnson, Eric Boerwinkle, Juan M. Peralta, Michael H. Cho, Jiang He, Amanda L. Tapia, Jessica Lasky-Su, Scott T. Weiss, Edwin K. Silverman, Mary Cushman, L. Adrienne Cupples, Robert C. Kaplan, Yue Shan, Lisa R. Yanek, Marguerite R. Irvin, Paul L. Auer, Tanika N. Kelly, Hélène Choquet, Stacey Gabriel, Yun Li, Deepti Jain, Steve Buyske, Sebastian Zöllner, Nicholette D. Palmer, Caitlin P. McHugh, Michelle Daya, Jee-Young Moon, Patricia A. Peyser, Patrick T. Ellinor, Paul S. de Vries, Ruth J. F. Loos, Steven A. Lubitz, Timothy A. Thornton, Donald W. Bowden, Christy L. Avery, Courtney G. Montgomery, Misa Graff, Jonathan D. Rosen, Seung Hoan Choi, Kent D. Taylor, Kathleen C. Barnes, Rasika A. Mathias, George Papanicolaou, Santhi K. Ganesh, Alanna C. Morrison, Maria Argos, Nicholas L. Smith, Stephen S. Rich, Donna K. Arnett, Myriam Fornage, Namrata Gupta, Lewis C. Becker, Madeline H. Kowalski, Jennifer A. Smith, Lu-Chen Weng, Eric Jorgenson, Chani J. Hodonsky, Joshua C. Bis, Kari E. North, Jianwen Cai, Ziyi Hou, Jerome I. Rotter, Susan R. Heckbert, Stephanie A. Bien, John Blangero, Sharon L.R. Kardia, Kerri L. Wiggins, Russell P. Tracy, James G. Wilson, Nathan Pankratz, Huijun Qian, Nauder Faraday, Tao Wang, Bertha Hidalgo, Charles Kooperberg, Hemant K. Tiwari
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 12, p e1008500 (2019)
PLoS Genetics, Vol 15, Iss 12, p e1008500 (2019)
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0704998c62e9584f7c2aae45f775edb3
https://doi.org/10.1101/683201
https://doi.org/10.1101/683201
Autor:
Thomas U. Ahearn, Nick Orr, Yan Zhang, Mark N. Brook, Montserrat Garcia-Closas, Michael Jones, Anthony J. Swerdlow, Parichoy Pal Choudhury, Nilanjan Chatterjee, Minouk J. Schoemaker, Amber N. Wilcox, Penny Coulson, Mitchell H. Gail
Background External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development and comparative model validatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40afce0e27307a87bb6a10a7ce0dd41a
https://doi.org/10.1101/440347
https://doi.org/10.1101/440347
Autor:
Riku Katainen, Lauri A. Aaltonen, Ari Ristimäki, Ulrika A. Hänninen, Esa Pitkänen, Aurora Taira, Linda M. Forsström, Tomas Tanskanen, Selja Koskensalo, Niko Välimäki, Laura Renkonen-Sinisalo, Johanna Kondelin, Eevi Kaasinen, Outi Kilpivaara, Teijo Kuopio, Anna Lepistö, Jukka-Pekka Mecklin, Jan Böhm, Tatiana Cajuso, Mervi Aavikko, Päivi Sulo, Kimmo Palin, Toni T. Seppälä
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8998dfee8806250d53911716f8a6b7b
https://doi.org/10.1101/443580
https://doi.org/10.1101/443580
Autor:
Takahiko Toyonaga, Nicole Chaumont, Neil D. Shah, Mark J. Koruda, Matt Kanke, Greg R Gipson, Michelle Hoffner O’Connor, Elisabeth A. Wolber, Dimitri G. Trembath, Terrence S. Furey, Jasmine B. Barrow, Wendy A. Pitman, Nevzat Kazgan, Nancy L. Allbritton, Matthew S Schaner, Paul A Cotney, Francisco A. Sylvester, Omar K. Trad, Praveen Sethupathy, Benjamin P. Keith, Shruti J Saxena, Timothy S. Sadiq, Shehzad Z. Sheikh
BACKGROUND. Crohn’s disease (CD) is highly heterogeneous, due in large part to variability in cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There is a critical need to advance understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7d423af630bb33d43122d4a5c5e6a9
https://doi.org/10.1101/307561
https://doi.org/10.1101/307561