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Autor:
Mengcheng Luo, Yuming Cao, Cong Liu, Rong Liu, Zhe Yang, Zhen Chen, Ziye Du, Peng Cui, Qi Sun, Zejia Li, Jiong Li
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1527-1537
Liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in mammal cells. However, there are few reports that focus on the correlation of mouse oocyte maturation with LLPS. Previous studies have reported that paraspe
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1558-1566
Tumor acidic microenvironment is the main feature of many solid tumors. As a part of the tumor microenvironment, it has a profound impact on the occurrence and development of tumors. However, the research on how tumor cells sense the changes of the e
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1428-1439
Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro; thus, they have a great potential in the treatment of hemopathies. Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR). How
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1333-1341
Endometrial dysfunction is an important factor for implantation failure. The function of the endometrium is regulated by multiple factors like sex hormones and circadian rhythms. Endometrial stromal cells (ESCs) are a major cellular component in the
Publikováno v:
Acta Biochimica et Biophysica Sinica
SUMOylation of proteins regulates cell behaviors and is reversibly removed by small ubiquitin-like modifier (SUMO)-specific proteases (SENPs). The SENP family member SENP3 is involved in SUMO2/3 deconjugation and has been reported to sense cell stres
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1037-1043
Ubiquitin-specific protease 31 (USP31) is a member of deubiquitinase family that is involved in nuclear factor-κB activation and sarcomagenesis. However, little is known about posttranslational modification in the regulation of its activity and cerv
Autor:
Liwei Wang, Daping Wang, Huankun Fang, Lu Minqiang, Zicong Lin, Lixin Chen, Liu Jianquan, Wencui Li, Qing Zhong, Deng Zhiqin, Li Duan
Publikováno v:
Acta Biochimica et Biophysica Sinica
Persistent hypotonic and inflammatory conditions in the joint cavity can lead to the loss of cartilage matrix and cell death, which are the important mechanisms of osteoarthritis (OA) onset. Previous studies have confirmed that the existence of a hyp
Autor:
Zhiyuan Sun, Wen Yuan, Shuai Li, Hua-Qun Chen, Qianqian Zhang, Min-Sheng Zhu, Li Liu, Tengxiang Ma, Jing Li, Xiaobin Song, Weiwei Zeng
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:567-574
Leucocyte adhesion to the vascular endothelium is a critical event in the early inflammatory response to infection and injury. This process is primarily regulated by the expression of cell adhesion molecules (CAMs) in endothelial cells. It has been w
Autor:
Shu-Juan Guo, He-wei Jiang, Chuansheng Hu, Nan Wang, Yani Kang, Yang Li, Zhaowei Xu, Hai-nan Zhang, Dan-yun Lai, Huan Qi, Hua Li, Fan-Lin Wu, Xiaodong Zhao, Qing-Feng Meng, Ming-liang Ma, Sheng-Ce Tao
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:628-635
PD-1 plays an important role as an immune checkpoint. Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1. In this study, to elucidate the molecular mechanism by which sintilimab blocks PD-1 a
Publikováno v:
Acta Biochimica et Biophysica Sinica. 52:1093-1101
Previously, Nucleolar protein 66 (NO66) was reported to be closely associated with alcohol exposure-induced injury. However, the role of NO66 in alcohol-induced cytotoxicity remains unclear. In this study, we explored the potential effect and mechani