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Autor:
Ximing Du, Hongyuan Yang
Publikováno v:
Acta Biochimica et Biophysica Sinica. 45:11-17
The delivery of low-density lipoprotein-derived cholesterol (LDL-C) from endosomal compartments to the plasma membrane and the endoplasmic reticulum (ER) is an important yet poorly understood cellular process. Niemann-Pick C1 (NPC1), a multi-pass int
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:424-430
MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:347-358
Human cervical cancer HeLa cells have functional mitochondria. Recent studies have suggested that mitochondrial metabolism plays an essential role in tumor cell proliferation. Nevertheless, how cells coordinate mitochondrial dynamics and cell cycle p
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:197-206
Human-induced pluripotent stem (iPS) cells share the same key properties as embryonic stem cells, and may be generated from patient- or disease-specific sources, which makes them attractive for personalized medicine, drug screens, or cellular therapy
Autor:
Xiao-Xu Li, Xiaohui Zha, Zhong-Cheng Mo, Zhi-Sheng Jiang, Xiao-Hua Yu, Chao-Ke Tang, Yuchang Fu, Kai Yin, Ji Xiao, Guo-Jun Zhao
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:119-128
The Niemann-Pick type C1 (NPC1) is located mainly in the membranes of the late endosome/lysosome and controls the intracellular cholesterol trafficking from the late endosome/lysosome to the plasma membrane. It has been reported that oxidized low-den
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:136-146
CS-1, a new alkaloid with a molecular formula of C(21)H(20)O(8)N(2)S, is extracted from traditional Chinese medicine. Previous studies have shown that CS-1 can inhibit the proliferation of several human carcinoma cells in vivo and in vitro. The aims
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:92-102
During mammalian development, cardiac specification and ultimately lineage commitment to a specific cardiac cell type is accomplished by the action of specific transcription factors (TFs) and their meticulous control on an epigenetic level. In this r
Autor:
Jiang Wu
Publikováno v:
Acta Biochimica et Biophysica Sinica. 44:54-69
Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. B
Autor:
John R. Sinnamon, Kevin Czaplinski
Publikováno v:
Acta Biochimica et Biophysica Sinica. 43:663-670
Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the reg
Autor:
Tsukasa Suzuki, Ken Inoki
Publikováno v:
Acta Biochimica et Biophysica Sinica. 43:671-679
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that regulates numerous cellular processes including cell growth, proliferation, cell cycle, and autophagy. mTOR forms two different multi-protein