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Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1189-1197
Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, i
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1223-1232
The pathogenesis of fatal neurodegenerative prion diseases is closely associated with the conversion of α-helix-rich cellular prion protein into β-sheet-rich scrapie form. Pathogenic point mutations of prion proteins usually promote the conformatio
Autor:
Zhirong Sun, Minmin Zhu, Shan Zhang, Xiangyuan Chen, Wankun Chen, Xuqin Zhu, Qichao Wu, Changhong Miao, Jie Qi
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1114-1122
Propofol is one of the most commonly used intravenous anesthetics and plays an important role in tumor suppression. In the present study, we aimed to investigate the mechanism by which propofol attenuates tumor endothelial cells (TECs) and tumor cell
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1087-1095
Autophagy, a metabolic pathway that plays an important role in maintaining the dynamic balance of cells, has two types, i.e. non-selective autophagy and selective autophagy. The role of non-selective autophagy is primarily to allow cells to circulate
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1041-1048
The development of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a significant advancement in our ability to obtain cardiomyocytes in vitro for regenerative therapies and drug discovery. However, hPSC-CMs obtained via existing prot
Publikováno v:
Acta Biochimica et Biophysica Sinica. 52:698-700
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:856-863
Extracellular matrix (ECM) including fibronectin (FN) and elastin plays a pivotal role in providing a microenvironment to support tissue regeneration in stem cell therapy. To develop a novel biomimetic ECM for stem cell differentiation, we engineered
Autor:
Zhibin Yang, Ke Duan, Qinghua Cui, Jiaji Zi, Wei Xiong, Min Yu, Zai-Yi Fei, Yang Sun, Qian-Qian Liu
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:707-714
Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell
Autor:
Jingchuan Sun, Yu Chen, Weiguo Zou, Haisong Yang, Shunmin Wang, Bing Zheng, Yongfei Guo, Jiangang Shi
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:570-578
The functional changes of nucleus pulposus (NP) cells are considered to be the initiating factors of intervertebral disc degeneration (IDD), and the differentially expressed circRNAs in NP cells may play an important role in the process of IDD. To id
Autor:
Li-yuan Zhong, Jing Yang, Guo-Jun Zhao, Wei Xie, Wei Wan, Tianhong Peng, Sha Sun, Xi Chen, Dongming Guo, Chao-Ke Tang, Yun-Cheng Lv, Suyun Li, Xi-Long Zheng, Anbo Gao
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:471-483
Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis (AS). The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood. In this study, we investigated the effect of macrophage sort