Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Reedik Mägi"'
Autor:
Cindy G. Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T. Wu, Jie Zheng, April Hartley, Maris Teder-Laving, Anne Heidi Skogholt, Chikashi Terao, Eleni Zengini, George Alexiadis, Andrei Barysenka, Gyda Bjornsdottir, Maiken E. Gabrielsen, Arthur Gilly, Thorvaldur Ingvarsson, Marianne B. Johnsen, Helgi Jonsson, Margreet Kloppenburg, Almut Luetge, Sigrun H. Lund, Reedik Mägi, Massimo Mangino, Rob R.G.H.H. Nelissen, Manu Shivakumar, Julia Steinberg, Hiroshi Takuwa, Laurent F. Thomas, Margo Tuerlings, George C. Babis, Jason Pui Yin Cheung, Jae Hee Kang, Peter Kraft, Steven A. Lietman, Dino Samartzis, P. Eline Slagboom, Kari Stefansson, Unnur Thorsteinsdottir, Jonathan H. Tobias, André G. Uitterlinden, Bendik Winsvold, John-Anker Zwart, George Davey Smith, Pak Chung Sham, Gudmar Thorleifsson, Tom R. Gaunt, Andrew P. Morris, Ana M. Valdes, Aspasia Tsezou, Kathryn S.E. Cheah, Shiro Ikegawa, Kristian Hveem, Tõnu Esko, J. Mark Wilkinson, Ingrid Meulenbelt, Ming Ta Michael Lee, Joyce B.J. van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini, John Loughlin, Nigel Arden, Fraser Birrell, Andrew Carr, Panos Deloukas, Michael Doherty, Andrew W. McCaskie, William E.R. Ollier, Ashok Rai, Stuart H. Ralston, Tim D. Spector, Gillian A. Wallis, Amy E. Martinsen, Cristen Willer, Egil Andreas Fors, Ingunn Mundal, Knut Hagen, Kristian Bernhard Nilsen, Marie Udnesseter Lie, Sigrid Børte, Ben Brumpton, Jonas Bille Nielsen, Lars G. Fritsche, Wei Zhou, Ingrid Heuch, Kjersti Storheim, Evangelos Tyrpenou, Athanasios Koukakis, Dimitrios Chytas, Dimitrios Stergios Evangelopoulos, Chronopoulos Efstathios, Spiros Pneumaticos, Vasileios S. Nikolaou, Konstantinos Malizos, Lydia Anastasopoulou, Goncalo Abecasis, Aris Baras, Michael Cantor, Giovanni Coppola, Andrew Deubler, Aris Economides, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Katia Karalis, Katherine Siminovitch, Christina Beechert, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Michael Lattari, Alexander Lopez, Thomas D. Schleicher, Maria Sotiropoulos Padilla, Louis Widom, Sarah E. Wolf, Manasi Pradhan, Kia Manoochehri, Xiaodong Bai, Suganthi Balasubramanian, Boris Boutkov, Gisu Eom, Lukas Habegger, Alicia Hawes, Olga Krasheninina, Rouel Lanche, Adam J. Mansfield, Evan K. Maxwell, Mona Nafde, Sean O’Keeffe, Max Orelus, Razvan Panea, Tommy Polanco, Ayesha Rasool, William Salerno, Jeffrey C. Staples, Dadong Li, Deepika Sharma, Ilanjana Banerjee, Jonas Bovijn, Adam Locke, Niek Verweij, Mary Haas, George Hindy, Tanima De, Parsa Akbari, Olukayode Sosina, Manuel A.R. Ferreira, Marcus B. Jones, Jason Mighty, Michelle G. LeBlanc, Lyndon J. Mitnaul
Publikováno v:
Cell
Cell 184, 4784-4818.e17 (2021)
Cell, 184(18), 4784-4818. CELL PRESS
Cell, 184(18), 4784-4818.e17. Cell Press
Boer, C G, Hatzikotoulas, K, Southam, L, Stefansdottir, L, Zhang, Y, Coutinho de Almeida, R, wu, T T, Zhang, J, Hartley, A E, Teder-Laving, M, Skogholt, A H, Terao, C, Zengini, E, Alexiadis, G, Barysenka, A, Bjornsdottir, G, Gabrielsen, M, Gilly, A, Ingvarsson, T, Johnsen, M B, Jonsson, H, Kloppenburg, M, Luetge, A, Lund, S H, Mägi, R, Mangino, M, Nelissen, R, Shivakumar, M, Steinberg, J, Takuwa, H, Thomas, L, Tuerlings, M, Babis, G C, Pui Yin Cheung, J, Kang, J H, Kraft, P, Lietman, S A, Samartzis, D, Slagboom, E, Stefansson, K, Thorsteinsdottir, U, Tobias, J H, Uitterlinden, A G, Winsvold, B S, Zwart, J-A, Davey Smith, G, Sham, P C, Thorleifsson, G, Gaunt, T R, Morris, A, Valdes, A M, Tsezou, A, S.E. Cheah, K, Ikegawa, S, Hveem, K, Esko, T, Wilkinson, J M, Meulenbelt, I, Ta Michael Lee, M, van Meurs, J B J, Styrkarsdottir, U & Zeggini, E 2021, ' Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations ', Cell, vol. 184, no. 18, pp. 4784-4818.e17 . https://doi.org/10.1016/j.cell.2021.07.038
Cell 184, 4784-4818.e17 (2021)
Cell, 184(18), 4784-4818. CELL PRESS
Cell, 184(18), 4784-4818.e17. Cell Press
Boer, C G, Hatzikotoulas, K, Southam, L, Stefansdottir, L, Zhang, Y, Coutinho de Almeida, R, wu, T T, Zhang, J, Hartley, A E, Teder-Laving, M, Skogholt, A H, Terao, C, Zengini, E, Alexiadis, G, Barysenka, A, Bjornsdottir, G, Gabrielsen, M, Gilly, A, Ingvarsson, T, Johnsen, M B, Jonsson, H, Kloppenburg, M, Luetge, A, Lund, S H, Mägi, R, Mangino, M, Nelissen, R, Shivakumar, M, Steinberg, J, Takuwa, H, Thomas, L, Tuerlings, M, Babis, G C, Pui Yin Cheung, J, Kang, J H, Kraft, P, Lietman, S A, Samartzis, D, Slagboom, E, Stefansson, K, Thorsteinsdottir, U, Tobias, J H, Uitterlinden, A G, Winsvold, B S, Zwart, J-A, Davey Smith, G, Sham, P C, Thorleifsson, G, Gaunt, T R, Morris, A, Valdes, A M, Tsezou, A, S.E. Cheah, K, Ikegawa, S, Hveem, K, Esko, T, Wilkinson, J M, Meulenbelt, I, Ta Michael Lee, M, van Meurs, J B J, Styrkarsdottir, U & Zeggini, E 2021, ' Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations ', Cell, vol. 184, no. 18, pp. 4784-4818.e17 . https://doi.org/10.1016/j.cell.2021.07.038
Summary Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107ed7b2af740104437a8ef894bb702
http://hdl.handle.net/10852/89014
http://hdl.handle.net/10852/89014
Autor:
Anne-Claire Vergnaud, Nauder Faraday, Tim Kacprowski, Lisa R. Yanek, Oscar H. Franco, Yongmei Liu, Andreas Greinacher, Gina M. Peloso, Cristen J. Willer, Leslie A. Lange, Eric S. Torstenson, Reedik Mägi, Jeanette Erdmann, Ethan M. Lange, Deborah A. Nickerson, Henry Völzke, David R. Crosslin, Gunnar Engström, Albert V. Smith, André G. Uitterlinden, Salman M. Tajuddin, W. David Hill, Diane M. Becker, Paul Elliot, Caterina Vacchi-Suzzi, Linda M. Polfus, Traci M. Bartz, Nathalie Chami, Abbas Dehghan, Mike A. Nalls, John D. Eicher, Leo-Pekka Lyytikäinen, Evelin Mihailov, Uwe Völker, Caroline Hayward, Ioanna Tzoulaki, Myriam Fornage, Marju Orho-Melander, Mary Cushman, Lars Wallentin, Terho Lehtimäki, Ayush Giri, Laura M. Raffield, Lewis C. Becker, Yingchang Lu, Emma Raitoharju, Sekar Kathiresan, Simon de Denus, Ruth J. F. Loos, James S. Floyd, Dawn M. Waterworth, James G. Wilson, Nathan Pankratz, Lenore J. Launer, Andrew D. Johnson, Andrew J. Slater, Jean-Claude Tardif, Raha Pazoki, Evangelos Evangelou, Kenneth Rice, Harvey D. White, Marie-Pierre Dubé, Frank J. A. van Rooij, Akihiro Nomura, Tamara B. Harris, Vilmundur Gudnason, Gonçalo R. Abecasis, Alan B. Zonderman, Guillaume Lettre, Todd L. Edwards, Amber A. Burt, Ani Manichaikul, Heribert Schunkert, Ming-Huei Chen, Ian J. Deary, Michelle L. O'Donoghue, Jennifer A. Brody, Russell P. Tracy, Tõnu Esko, Mika Kähönen, Panos Deloukas, Eric Boerwinkle, Rasika A. Mathias, Dajiang J. Liu, Jin Li, Santhi K. Ganesh, David C. Liewald, Paul L. Auer, Digna R. Velez Edwards, Erwin P. Bottinger, Nina Mononen, Claudia Schurmann, Michele K. Evans, John M. Starr, Thomas Thiele, Jussi Hernesniemi, Jerome I. Rotter, Rakale C. Quarells, He Gao, Kjell Nikus, Stephen S. Rich, Heather M. Highland, Bruce M. Psaty, Ursula M. Schick, Andres Metspalu, Melissa A. Richard, Neil A. Zakai, Olle Melander, John D. Rioux, Olli T. Raitakari, Alexander P. Reiner, Joel N. Hirschhorn, Nilesh J. Samani
Publikováno v:
American Journal of Human Genetics, 99(1), 40-55. Cell Press
Eicher, J D, Chami, N, Kacprowski, T, Nomura, A, Chen, M-H, Yanek, L R, Tajuddin, S M, Schick, U M, Slater, A J, Pankratz, N, Polfus, L, Schurmann, C, Giri, A, Brody, J A, Lange, L A, Manichaikul, A, Hill, W D, Pazoki, R, Elliot, P, Evangelou, E, Tzoulaki, I, Gao, H, Vergnaud, A-C, Mathias, R A, Becker, D M, Becker, L C, Burt, A, Crosslin, D R, Lyytikäinen, L-P, Nikus, K, Hernesniemi, J, Kähönen, M, Raitoharju, E, Mononen, N, Raitakari, O T, Lehtimäki, T, Cushman, M, Zakai, N A, Nickerson, D A, Raffield, L M, Quarells, R, Willer, C J, Peloso, G M, Abecasis, G R, Liu, D J, Deloukas, P, Starr, J M, Liewald, D C M & Hayward, C & Deary, I J 2016, ' Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals ', American Journal of Human Genetics, vol. 99, no. 1, pp. 40-55 . https://doi.org/10.1016/j.ajhg.2016.05.005
The American Journal of Human Genetics
Eicher, J D, Chami, N, Kacprowski, T, Nomura, A, Chen, M-H, Yanek, L R, Tajuddin, S M, Schick, U M, Slater, A J, Pankratz, N, Polfus, L, Schurmann, C, Giri, A, Brody, J A, Lange, L A, Manichaikul, A, Hill, W D, Pazoki, R, Elliot, P, Evangelou, E, Tzoulaki, I, Gao, H, Vergnaud, A-C, Mathias, R A, Becker, D M, Becker, L C, Burt, A, Crosslin, D R, Lyytikäinen, L-P, Nikus, K, Hernesniemi, J, Kähönen, M, Raitoharju, E, Mononen, N, Raitakari, O T, Lehtimäki, T, Cushman, M, Zakai, N A, Nickerson, D A, Raffield, L M, Quarells, R, Willer, C J, Peloso, G M, Abecasis, G R, Liu, D J, Deloukas, P, Starr, J M, Liewald, D C M & Hayward, C & Deary, I J 2016, ' Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals ', American Journal of Human Genetics, vol. 99, no. 1, pp. 40-55 . https://doi.org/10.1016/j.ajhg.2016.05.005
The American Journal of Human Genetics
Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are
Autor:
Yingchang Lu, Lisa R. Yanek, Evangelos Evangelou, Andreas Greinacher, Leslie A. Lange, Albert Hofman, Rakale C. Quarells, Christopher J. O'Donnell, Simon de Denus, Marcus Dörr, Tamara B. Harris, Mary Cushman, Lars Wallentin, Digna R. Velez Edwards, Michelle L. O'Donoghue, Deborah A. Nickerson, Lisa Bastarache, Caterina Vacchi-Suzzi, Harvey D. White, Rasika A. Mathias, Jin Li, Santhi K. Ganesh, Leo-Pekka Lyytikäinen, Kjell Nikus, Ayush Giri, Paul Elliott, John M. Starr, Ruth J. F. Loos, Vilmundur Gudnason, Ioanna Tzoulaki, Myriam Fornage, Joshua C. Denny, Alan B. Zonderman, Caroline Hayward, Lewis C. Becker, Raha Pazoki, Guillaume Lettre, Lenore J. Launer, Ursula M. Schick, Michele K. Evans, Andrew J. Slater, Diane M. Becker, Jean-Claude Tardif, Ethan M. Lange, John D. Eicher, He Gao, James S. Floyd, Eric Boerwinkle, Paul L. Auer, Nathalie Chami, Frank J. A. van Rooij, Claudia Schurmann, Nele Friedrich, Kent D. Taylor, Andres Metspalu, Todd L. Edwards, Anne-Claire Vergnaud, Yongmei Liu, W. David Hill, Nauder Faraday, Terho Lehtimäki, Amber A. Burt, Jerome I. Rotter, Albert V. Smith, Tõnu Esko, Traci M. Bartz, Tim Kacprowski, Mike A. Nalls, Alexander P. Reiner, Ani Manichaikul, Ian J. Deary, Eric S. Torstenson, Laura M. Raffield, David C. Liewald, Ming-Huei Chen, Erwin P. Bottinger, Reedik Mägi, Andrew D. Johnson, Melissa A. Richard, Neil A. Zakai, John D. Rioux, Mika Kähönen, Stephen S. Rich, Heather M. Highland, Bruce M. Psaty, Joel N. Hirschhorn, Salman M. Tajuddin, Linda M. Polfus, Dawn M. Waterworth, James G. Wilson, Nathan Pankratz, Abbas Dehghan, Evelin Mihailov, David R. Crosslin, André G. Uitterlinden, Georg Homuth, Jennifer A. Brody
Publikováno v:
The American Journal of Human Genetics
Tajuddin, S M, Schick, U M, Eicher, J D, Chami, N, Giri, A, Brody, J A, Hill, W D, Kacprowski, T, Li, J, Lyytikäinen, L-P, Manichaikul, A, Mihailov, E, O'Donoghue, M L, Pankratz, N, Pazoki, R, Polfus, L M, Smith, A V, Schurmann, C, Vacchi-Suzzi, C, Waterworth, D M, Evangelou, E, Yanek, L R, Burt, A, Chen, M-H, van Rooij, F J A, Floyd, J S, Greinacher, A, Harris, T B, Highland, H M, Lange, L A, Liu, Y, Mägi, R, Nalls, M A, Mathias, R A, Nickerson, D A, Nikus, K, Starr, J M, Tardif, J-C, Tzoulaki, I, Velez Edwards, D R, Wallentin, L, Bartz, T M, Becker, L C, Denny, J C, Raffield, L M, Rioux, J D, Friedrich, N, Fornage, M, Gao, H, Hirschhorn, J N, Liewald, D C M, Rich, S S, Uitterlinden, A, Bastarache, L, Becker, D M, Boerwinkle, E, de Denus, S, Bottinger, E P, Hayward, C, Hofman, A, Homuth, G, Lange, E, Launer, L J, Lehtimäki, T, Lu, Y, Metspalu, A, O'Donnell, C J, Quarells, R C, Richard, M, Torstenson, E S, Taylor, K D, Vergnaud, A-C, Zonderman, A B, Crosslin, D R, Deary, I J, Dörr, M, Elliott, P, Evans, M K, Gudnason, V, Kähönen, M, Psaty, B M, Rotter, J I, Slater, A J, Dehghan, A, White, H D, Ganesh, S K, Loos, R J F, Esko, T, Faraday, N, Wilson, J G, Cushman, M, Johnson, A D, Edwards, T L, Zakai, N A, Lettre, G, Reiner, A P & Auer, P L 2016, ' Large-scale exome-wide association analysis identifies loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases ', American Journal of Human Genetics, vol. 99, no. 1, pp. 22-39 . https://doi.org/10.1016/j.ajhg.2016.05.003
American journal of human genetics, vol 99, iss 1
American Journal of Human Genetics, 99(1), 22-39. Cell Press
Tajuddin, S M, Schick, U M, Eicher, J D, Chami, N, Giri, A, Brody, J A, Hill, W D, Kacprowski, T, Li, J, Lyytikäinen, L-P, Manichaikul, A, Mihailov, E, O'Donoghue, M L, Pankratz, N, Pazoki, R, Polfus, L M, Smith, A V, Schurmann, C, Vacchi-Suzzi, C, Waterworth, D M, Evangelou, E, Yanek, L R, Burt, A, Chen, M-H, van Rooij, F J A, Floyd, J S, Greinacher, A, Harris, T B, Highland, H M, Lange, L A, Liu, Y, Mägi, R, Nalls, M A, Mathias, R A, Nickerson, D A, Nikus, K, Starr, J M, Tardif, J-C, Tzoulaki, I, Velez Edwards, D R, Wallentin, L, Bartz, T M, Becker, L C, Denny, J C, Raffield, L M, Rioux, J D, Friedrich, N, Fornage, M, Gao, H, Hirschhorn, J N, Liewald, D C M, Rich, S S, Uitterlinden, A, Bastarache, L, Becker, D M, Boerwinkle, E, de Denus, S, Bottinger, E P, Hayward, C, Hofman, A, Homuth, G, Lange, E, Launer, L J, Lehtimäki, T, Lu, Y, Metspalu, A, O'Donnell, C J, Quarells, R C, Richard, M, Torstenson, E S, Taylor, K D, Vergnaud, A-C, Zonderman, A B, Crosslin, D R, Deary, I J, Dörr, M, Elliott, P, Evans, M K, Gudnason, V, Kähönen, M, Psaty, B M, Rotter, J I, Slater, A J, Dehghan, A, White, H D, Ganesh, S K, Loos, R J F, Esko, T, Faraday, N, Wilson, J G, Cushman, M, Johnson, A D, Edwards, T L, Zakai, N A, Lettre, G, Reiner, A P & Auer, P L 2016, ' Large-scale exome-wide association analysis identifies loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases ', American Journal of Human Genetics, vol. 99, no. 1, pp. 22-39 . https://doi.org/10.1016/j.ajhg.2016.05.003
American journal of human genetics, vol 99, iss 1
American Journal of Human Genetics, 99(1), 22-39. Cell Press
White blood cells play diverse roles in innate and adaptive immunity. Genetic association analyses of phenotypic variation in circulating white blood cell (WBC) counts from large samples of otherwise healthy individuals can provide insights into gene