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Publikováno v:
Canadian Journal of Physiology and Pharmacology. 98:415-430
Over the past 66 years, our knowledge of the role of the endothelium in the regulation of cardiovascular function and dysfunction has advanced from the assumption that it is a single layer of cells that serves as a barrier between the blood stream an
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 97:708-720
This study examined the effect of the aromatase inhibitor letrozole (0.5 mg/kg) alone or in combination with the angiotensin-receptor blocker valsartan (30 mg/kg) against streptozocin-induced diabetic nephropathy (DN) in hypogonadal (HG) rats for 12
Publikováno v:
Canadian Journal of Physiology and Pharmacology
This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:1084-1091
Preeclampsia is an inflammatory disease and has connection with increased pro-inflammatory cytokines. Aspirin reduces the incidence of preeclampsia complications. However, the effects of aspirin on lipopolysaccharide-induced preeclampsia-like symptom
Autor:
Pamela Mondragon, Andreas Bergdahl
Publikováno v:
FACETS, Vol 3, Pp 315-325 (2018)
Type 1 diabetes (T1DM) is known to cause an increase in reactive oxygen species (ROS) and elevated intracellular glucose levels. We investigated the metallothionein I and II (MT I+II) antioxidants expression in soleus (mainly slow-twitch) and plantar
Autor:
Shota Kobayashi, Maika Iguchi, Kumiko Taguchi, Takayuki Matsumoto, Tsuneo Kobayashi, Makoto Ando
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:839-844
The purpose of this study was to determine the relationship of KCa channels to endothelium-dependent hyperpolarizing factor (EDHF)-mediated relaxation induced by acetylcholine (ACh) in the superior mesenteric arteries of 7-month-old spontaneously hyp
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:823-829
The purpose of the present study was to utilize the microdialysis technique in rat skeletal muscle to perfuse varying concentrations of AMP, ADP, and ATP into the interstitium to examine the effects that these adenine nucleotides have on the producti
Autor:
Angelo Rafael Carpinelli, Helenir Medri de Souza, Priscila Cassolla, Flaviane de Fatima Silva, Winny Beatriz de Souza Galia, Maria Fernanda Rodrigues Graciano, Francemilson Goulart da Silva, Milene Ortiz-Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investig
Autor:
Alireza Sarkaki, Sahreh Shabani, Akram Ahangarpour, Yaghoob Farbood, Layasadat Khorsandi, Seyyed Ali Mard
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:275-280
Alzheimer’s disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and decreased protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hipp
Autor:
Isabelle M. Côté, Philip J. Scarpace, Sara M. Green, Nihal Tümer, Drake Morgan, Christy S. Carter
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:308-312
Recent evidence indicate that melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examin