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Publikováno v:
Canadian Journal of Physiology and Pharmacology
This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the
Autor:
Angelo Rafael Carpinelli, Helenir Medri de Souza, Priscila Cassolla, Flaviane de Fatima Silva, Winny Beatriz de Souza Galia, Maria Fernanda Rodrigues Graciano, Francemilson Goulart da Silva, Milene Ortiz-Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investig
Autor:
Alireza Sarkaki, Sahreh Shabani, Akram Ahangarpour, Yaghoob Farbood, Layasadat Khorsandi, Seyyed Ali Mard
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:275-280
Alzheimer’s disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and decreased protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hipp
Autor:
Semil Selcen Gocmez, Tuğçe Demirtaş Şahin, Selenay Furat Rençber, Gulcin Gacar, Tijen Utkan, Yusufhan Yazir
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:200-207
Erectile dysfunction (ED) has been reported to be associated with inflammation. This study investigated the effects of tumor necrosis factor alpha (TNF-α) inhibitor etanercept on penile neuronal nitric oxide synthase (nNOS) and endothelial nitric ox
Autor:
Aline Haas de Mello, Larissa Colonetti Cardoso, Jucélia Jeremias Fortunato, Gislaine T. Rezin, Naiana da Rosa, Rosiane de Bona Schraiber, Gabriela K. Ferreira, Morgana Prá, Luana da Rosa Souza
Publikováno v:
Biochemistry and Cell Biology. 94:451-458
Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide o
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 94:858-867
In this study, the possible therapeutic effects of various ATP-sensitive potassium channel (KATP) blockers (glibenclamide, repaglinide, 5-HD, HMR-1098) have been tested in experimental septic shock model. Rats were given lipopolysaccharide (1 mg·kg
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 94:296-301
Stress is known to precipitate neuropsychiatric diseases, and depending upon its nature and intensity it can also influence the functioning of the immune system. Melatonin (N-acetyl-5-methoxy tryptamine) a pineal gland hormone and potent antioxidant
Autor:
Eman S.H. Abd Allah, Asmaa M.S. Gomaa
Publikováno v:
Applied Physiology, Nutrition, and Metabolism. 40:1061-1067
Oxidative stress and inflammation are involved in the development and progression of diabetes and its complications. The renin–angiotensin system also plays an important role in the pathogenesis of diabetes and its complications. We hypothesized th
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 93:517-525
Little is known about metabolic syndrome (MetS)-associated cardiomyopathy, especially in relation to the role and contribution of beta-adrenoceptor (β-AR) subtypes. Therefore, we examined the roles of β-AR subtypes in the cardiac function of rats w
Autor:
Diorginis Soares Ferreira, Anderson Apolonio Pedroza, Reginaldo Silva-Filho, Claudia Jacques Lagranha, Glauber Rudá Feitoza Braz, Aline Isabel da Silva, Raul Manhães de Castro
Publikováno v:
Applied Physiology, Nutrition, and Metabolism. 40:565-574
Recent investigations have focused on the mitochondrion as a direct drug target in the treatment of metabolic diseases (obesity, metabolic syndrome). Relatively few studies, however, have explicitly investigated whether drug therapies aimed at changi